Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cyp2b10provided by MGI
Official Full Name: cytochrome P450, family 2, subfamily b, polypeptide 10provided by MGI
Primary source: MGI:MGI:88598
See related: Ensembl:ENSMUSG00000030483 AllianceGenome:MGI:88598
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p16; Cyp2b; Cyp2b20
Summary: Predicted to enable heat shock protein binding activity; heme binding activity; and monooxygenase activity. Acts upstream of or within response to bacterium. Predicted to be located in mitochondrial inner membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in several structures, including adrenal gland; gut; hemolymphoid system gland; liver; and lung. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; drug dependence (multiple); human immunodeficiency virus infectious disease; neonatal abstinence syndrome; and nicotine dependence. Orthologous to human CYP2B6 (cytochrome P450 family 2 subfamily B member 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in duodenum adult (RPKM 61.9), lung adult (RPKM 58.0) and 2 other tissues See more
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Genomic context

Location:: 7 A3; 7 14.11 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (25597083..25626049)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (25897658..25926624)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hepatic CYP2B10 is highly induced by binge ethanol and contributes to acute-on-chronic alcohol-induced liver injury.
Title: Hepatic CYP2B10 is highly induced by binge ethanol and contributes to acute-on-chronic alcohol-induced liver injury.
Protein Kinase N Family Negatively Regulates Constitutive Androstane Receptor-Mediated Transcriptional Induction of Cytochrome P450 2b10 in the Livers of Mice.
Title: Protein Kinase N Family Negatively Regulates Constitutive Androstane Receptor-Mediated Transcriptional Induction of Cytochrome P450 2b10 in the Livers of Mice.
Cyp2b-null male mice are susceptible to diet-induced obesity and perturbations in lipid homeostasis.
Title: Cyp2b-null male mice are susceptible to diet-induced obesity and perturbations in lipid homeostasis.
results from the present study demonstrate a novel regulatory role of PPARbeta/delta in modulating CYP2B10 that may contribute to the etiology of alcoholic liver disease.
Title: Regulation of Cytochrome P450 2B10 (CYP2B10) Expression in Liver by Peroxisome Proliferator-activated Receptor-β/δ Modulation of SP1 Promoter Occupancy.
Study demonstrated that in mouse livers,the redox-sensitive transcription factor Nrf2 is involved in the gene expression of Cyp2b10 and Cyp2a5.
Title: Possible involvement of nuclear factor erythroid 2-related factor 2 in the gene expression of Cyp2b10 and Cyp2a5.
Studies indicate that phenobarbital binding to EGFR inhibits distal signaling to derepress RACK1-facilitated dephosphorylation of constitutive active androstane receptor (CAR) by PP2A, and activates the transcription of Cyp2B10.
Title: Old dance with a new partner: EGF receptor as the phenobarbital receptor mediating Cyp2B expression.
expression of Cyp2b10 was induced in both WT and PXR-/- hypothyroid mice, and this induction was abolished in CAR-/- mice and in and CAR-/- PXR-/- double knockouts
Title: Opposing regulation of cytochrome P450 expression by CAR and PXR in hypothyroid mice.
Report lentiviral-mediated RNAi knockdown of multiple mouse Cyp2b enzymes.
Title: Lentiviral-mediated RNAi knockdown yields a novel mouse model for studying Cyp2b function.
Mice homozygous for a Werner's syndrome mutated liver helicase partial deletion show a decrease in basal and phenobarbital-induced CYP2B10 messenger RNA levels compared to wild-type animals.
Title: Werner's syndrome helicase participates in transcription of phenobarbital-inducible CYP2B genes in rat and mouse liver.
Drug metabolizing enzyme induction of Cyp2b10 is reported in experimental fatty liver.
Title: Drug metabolizing enzyme induction pathways in experimental non-alcoholic steatohepatitis.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1)

General gene information

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Markers

M21856 (e-PCR)
- UniSTS:124932

Cyp2b10 (e-PCR), detects polymorphism
- UniSTS:462990

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Hsp70 protein binding	ISO Inferred from Sequence Orthology more info
enables Hsp90 protein binding	ISO Inferred from Sequence Orthology more info
enables anandamide 11,12 epoxidase activity	ISO Inferred from Sequence Orthology more info
enables anandamide 14,15 epoxidase activity	ISO Inferred from Sequence Orthology more info
enables anandamide 8,9 epoxidase activity	ISO Inferred from Sequence Orthology more info
enables arachidonate epoxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables estrogen 2-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IEA Inferred from Electronic Annotation more info
enables steroid hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables testosterone 16-alpha-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables testosterone 16-beta-hydroxylase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in epoxygenase P450 pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ketone metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
involved_in steroid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic catabolic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in xenobiotic metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytochrome P450 2B10

Names: CYPIIB10; CYPIIB20; P24; cytochrome P450 2B20; cytochrome P450 clone PF3/46; cytochrome P450, 2b10, phenobarbitol inducible, type b; cytochrome P450, 2b20; cytochrome P450, family 2, subfamily b, polypeptide 20; cytochrome P450-16-alpha; phenobarbitol inducible, type b; testosterone 16-alpha hydroxylase

NP_034129.1

EC 1.14.14.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009999.4 → NP_034129.1 cytochrome P450 2B10 precursor

Status: VALIDATED

Source sequence(s)

AC160471, AI304065, AK028103

Consensus CDS

CCDS20999.1

UniProtKB/TrEMBL

G3X8Q9, Q9WUD0

Related

ENSMUSP00000072264.7, ENSMUST00000072438.13

Conserved Domains (1) summary

pfam00067
Location:42 → 488

p450; Cytochrome P450