Zfp318 zinc finger protein 318 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfp318provided by MGI
Official Full Name: zinc finger protein 318provided by MGI
Primary source: MGI:MGI:1889348
See related: Ensembl:ENSMUSG00000015597 AllianceGenome:MGI:1889348
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TZF; Znf318; 2610034E08Rik; D530032D06Rik
Summary: Enables protein heterodimerization activity and protein homodimerization activity. Involved in negative regulation of DNA-templated transcription and positive regulation of DNA-templated transcription. Located in nucleus. Is expressed in central nervous system; early conceptus; reproductive system; and urinary system. Orthologous to human ZNF318 (zinc finger protein 318). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 4.1), CNS E18 (RPKM 3.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 22.9 cM; 17 C

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (46694444..46731846)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (46383515..46420920)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ampk regulates IgD expression but not energy stress with B cell activation.
Title: Ampk regulates IgD expression but not energy stress with B cell activation.
Zfp318 is expressed as a functional protein in testicular germ cells and plays an important role in meiosis during spermatogenesis.
Title: Abnormal spermatogenesis and male infertility in testicular zinc finger protein Zfp318-knockout mice.
This finding indicates that Zfp318, in a novel manner, functions by repressing recognition of the transcriptional termination site at the 3' end of the terminal IgM-encoding exon
Title: Zfp318 regulates IgD expression by abrogating transcription termination within the Ighm/Ighd locus.
findings identify ZFP318 as a crucial factor regulating the expression of the two major antibody isotypes on the surface of most mature B cells
Title: Zinc-finger protein ZFP318 is essential for expression of IgD, the alternatively spliced Igh product made by mature B lymphocytes.
Molecular cloning and characteristics of a novel zinc finger protein and its splice variant whose transcripts are expressed during spermatogenesis.
Title: Molecular cloning and characteristics of a novel zinc finger protein and its splice variant whose transcripts are expressed during spermatogenesis.
in the unique regulation system of AR-mediated transactivation, two spliced isoforms of TZF act as coactivator and corepressor, respectively
Title: Opposite effects of alternative TZF spliced variants on androgen receptor.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2)
Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237656

43.MMHAP90FRG10.seq (e-PCR)
- UniSTS:124517

RH138719 (e-PCR)
- UniSTS:220806

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: zinc finger protein 318

Names: testicular zinc finger protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021346.2 → NP_067321.2 zinc finger protein 318 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks three exons and includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC151275, CT009572

Consensus CDS

CCDS28826.2

Related

ENSMUSP00000116544.2, ENSMUST00000138127.8

Conserved Domains (4) summary

smart00451
Location:1085 → 1114

ZnF_U1; U1-like zinc finger

pfam15087
Location:18 → 127

DUF4551; Protein of unknown function (DUF4551)

cd16269
Location:971 → 982

GBP_C; coiled coil [structural motif]

cl20817
Location:899 → 996

GBP_C; Guanylate-binding protein, C-terminal domain
NM_207671.4 → NP_997554.2 zinc finger protein 318 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC151275, AK157779, AW457229, BU704885, CD542244, CJ161473, CT009572

Consensus CDS

CCDS28827.2

UniProtKB/Swiss-Prot

B0V2M3, B9EK88, Q3TZL5, Q8BMX9, Q99PP2, Q9JJ01

Related

ENSMUSP00000109109.2, ENSMUST00000113481.9

Conserved Domains (3) summary

smart00451
Location:1155 → 1189

ZnF_U1; U1-like zinc finger

cl26511
Location:899 → 1031

Neuromodulin_N; Gap junction protein N-terminal region

cl28033
Location:18 → 142

Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

46694444..46731846

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011246554.4 → XP_011244856.1 zinc finger protein 318 isoform X1

Conserved Domains (2) summary

PTZ00121
Location:687 → 819

PTZ00121; MAEBL; Provisional

smart00451
Location:943 → 977

ZnF_U1; U1-like zinc finger