Kctd10 potassium channel tetramerisation domain containing 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kctd10provided by MGI
Official Full Name: potassium channel tetramerisation domain containing 10provided by MGI
Primary source: MGI:MGI:2141207
See related: Ensembl:ENSMUSG00000001098 AllianceGenome:MGI:2141207
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mBACURD3
Summary: Predicted to enable Notch binding activity and identical protein binding activity. Predicted to contribute to ubiquitin-protein transferase activity. Acts upstream of or within angiogenesis; heart development; and negative regulation of Notch signaling pathway. Part of MKS complex. Is expressed in clavicle; mandible; maxilla; midgut; and rib. Orthologous to human KCTD10 (potassium channel tetramerization domain containing 10). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in lung adult (RPKM 118.3), colon adult (RPKM 56.8) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 55.99 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (114501633..114518566, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (114363572..114380505, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KCTD10 regulates brain development by destabilizing brain disorder-associated protein KCTD13.
Title: KCTD10 regulates brain development by destabilizing brain disorder-associated protein KCTD13.
KCTD10 regulates brown adipose tissue thermogenesis and metabolic function via Notch signaling.
Title: KCTD10 regulates brown adipose tissue thermogenesis and metabolic function via Notch signaling.
Our studies suggest that KCTD10 plays crucial roles in embryonic angiogenesis and heart development in mammalians by negatively regulating the Notch signaling pathway.
Title: KCTD10 is involved in the cardiovascular system and Notch signaling during early embryonic development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW536343 (e-PCR)
- UniSTS:179236

C87062 (e-PCR)
- UniSTS:207854

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Notch binding	ISO Inferred from Sequence Orthology more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to ubiquitin-protein transferase activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
part_of Cul3-RING ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Cul3-RING ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
part_of MKS complex	IDA Inferred from Direct Assay more info	PubMed
part_of MKS complex	TAS Traceable Author Statement more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

Names: BTB/POZ domain-containing protein KCTD10; potassium channel tetramerization domain-containing 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159941.1 → NP_001153413.1 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK147714, AK161199, BB855690, BQ571808

Consensus CDS

CCDS51623.1

UniProtKB/TrEMBL

F8WGQ9

Related

ENSMUSP00000001125.6, ENSMUST00000001125.6

Conserved Domains (2) summary

smart00225
Location:33 → 131

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam02214
Location:34 → 124

BTB_2; BTB/POZ domain
NM_026145.4 → NP_080421.2 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 isoform 2

See identical proteins and their annotated locations for NP_080421.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1, which results in a protein (isoform 2) that is one amino acid shorter than isoform 1.

Source sequence(s)

AK147714, AK161199, BB855690

Consensus CDS

CCDS19563.1

UniProtKB/Swiss-Prot

Q922M3

Related

ENSMUSP00000099641.5, ENSMUST00000102581.11

Conserved Domains (2) summary

smart00225
Location:33 → 131

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam02214
Location:34 → 124

BTB_2; BTB/POZ domain