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    Pxmp4 peroxisomal membrane protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 59038, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Pxmp4provided by MGI
    Official Full Name
    peroxisomal membrane protein 4provided by MGI
    Primary source
    MGI:MGI:1891701
    See related
    Ensembl:ENSMUSG00000000876 AllianceGenome:MGI:1891701
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pmp24; 3010018P03Rik
    Summary
    Acts upstream of or within ether lipid metabolic process. Predicted to be located in peroxisome. Predicted to be active in peroxisomal membrane. Orthologous to human PXMP4 (peroxisomal membrane protein 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in liver adult (RPKM 36.1), kidney adult (RPKM 34.6) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pxmp4 in Genome Data Viewer
    Location:
    2 H1; 2 76.79 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (154427678..154445592, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (154585758..154603730, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene N-terminal EF-hand calcium binding protein 3 Neighboring gene STARR-positive B cell enhancer ABC_E816 Neighboring gene E2F transcription factor 1 Neighboring gene STARR-seq mESC enhancer starr_06129 Neighboring gene predicted gene, 39963 Neighboring gene STARR-seq mESC enhancer starr_06130 Neighboring gene STARR-positive B cell enhancer ABC_E228 Neighboring gene zinc finger protein 341 Neighboring gene predicted gene 14198 Neighboring gene STARR-positive B cell enhancer ABC_E7873 Neighboring gene STARR-positive B cell enhancer ABC_E6003 Neighboring gene charged multivesicular body protein 4B Neighboring gene RIKEN cDNA 9030607L20 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mice with a deficiency in Peroxisomal Membrane Protein 4 (PXMP4) display mild changes in hepatic lipid metabolism. Blankestijn M, et al. Sci Rep, 2022 Feb 15. PMID 35169201, Free PMC Article
    2. Congenic analysis of the NKT cell control gene Nkt2 implicates the peroxisomal protein Pxmp4. Fletcher JM, et al. J Immunol, 2008 Sep 1. PMID 18714012
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mice with a deficiency in Peroxisomal Membrane Protein 4 (PXMP4) display mild changes in hepatic lipid metabolism.
      Title: Mice with a deficiency in Peroxisomal Membrane Protein 4 (PXMP4) display mild changes in hepatic lipid metabolism.
    2. genetic sequences on chromosome 2 that control NKT cell numbers
      Title: Congenic analysis of the NKT cell control gene Nkt2 implicates the peroxisomal protein Pxmp4.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5)  1 citation
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within ether lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    peroxisomal membrane protein 4
    Names
    24 kDa intrinsic membrane protein
    24 kDa peroxisomal intrinsic membrane protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418211.1 → NP_001405140.1  peroxisomal membrane protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL772292, AL929557

    2. NM_001418212.1 → NP_001405141.1  peroxisomal membrane protein 4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL772292, AL929557

    3. NM_001418214.1 → NP_001405143.1  peroxisomal membrane protein 4 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL772292, AL929557

    4. NM_001418216.1 → NP_001405145.1  peroxisomal membrane protein 4 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL772292, AL929557
      UniProtKB/TrEMBL
      A2AKD6
      Related
      ENSMUSP00000105325.3, ENSMUST00000109703.3

    5. NM_001418221.1 → NP_001405150.1  peroxisomal membrane protein 4 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL772292, AL929557

    6. NM_021534.4 → NP_067509.1  peroxisomal membrane protein 4 isoform 1

      See identical proteins and their annotated locations for NP_067509.1

      Status: VALIDATED

      Source sequence(s)
      AL772292, AL929557
      Consensus CDS
      CCDS16936.1
      UniProtKB/Swiss-Prot
      Q3U0L9, Q9CQV9, Q9JJW0
      Related
      ENSMUSP00000000896.5, ENSMUST00000000896.11
      Conserved Domains (1) summary
      pfam02466
      Location:23 → 138
      Tim17; Tim17/Tim22/Tim23/Pmp24 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      154427678..154445592 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JJW0.3 GenPept UniProtKB/Swiss-Prot:Q9JJW0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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