Cxcl16 C-X-C motif chemokine ligand 16 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cxcl16provided by MGI
Official Full Name: C-X-C motif chemokine ligand 16provided by MGI
Primary source: MGI:MGI:1932682
See related: Ensembl:ENSMUSG00000018920 AllianceGenome:MGI:1932682
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SR-PSOX; Zmynd15; CXCL16v1; CXCL16v2; b2b498Clo; 0910001K24Rik
Summary: Enables chemokine activity; low-density lipoprotein particle receptor activity; and scavenger receptor activity. Involved in T cell chemotaxis and cellular response to lipopolysaccharide. Located in extracellular space and membrane. Is expressed in genitourinary system; meninges; and skin. Orthologous to human CXCL16 (C-X-C motif chemokine ligand 16). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in kidney adult (RPKM 38.8), lung adult (RPKM 36.7) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B3; 11 42.99 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (70345215..70350810, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (70454389..70459984, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Silencing CXCL16 alleviate neuroinflammation and M1 microglial polarization in mouse brain hemorrhage model and BV2 cell model through PI3K/AKT pathway.
Title: Silencing CXCL16 alleviate neuroinflammation and M1 microglial polarization in mouse brain hemorrhage model and BV2 cell model through PI3K/AKT pathway.
CXCL16-dependent scavenging of oxidized lipids by islet macrophages promotes differentiation of pathogenic CD8[+] T cells in diabetic autoimmunity.
Title: CXCL16-dependent scavenging of oxidized lipids by islet macrophages promotes differentiation of pathogenic CD8(+) T cells in diabetic autoimmunity.
CXCL16 exacerbates Pseudomonas aeruginosa keratitis by promoting neutrophil activation.
Title: CXCL16 exacerbates Pseudomonas aeruginosa keratitis by promoting neutrophil activation.
CXCL16 Promotes Ly6Chigh Monocyte Infiltration and Impairs Heart Function after Acute Myocardial Infarction.
Title: CXCL16 Promotes Ly6Chigh Monocyte Infiltration and Impairs Heart Function after Acute Myocardial Infarction.
Convergent transcriptomic and genomic evidence supporting a dysregulation of CXCL16 and CCL5 in Alzheimer's disease.
Title: Convergent transcriptomic and genomic evidence supporting a dysregulation of CXCL16 and CCL5 in Alzheimer's disease.
CXCL16 inhibits epithelial regeneration and promotes fibrosis during the progression of radiation enteritis.
Title: CXCL16 inhibits epithelial regeneration and promotes fibrosis during the progression of radiation enteritis.
Single-cell RNA transcriptome analysis of CNS immune cells reveals CXCL16/CXCR6 as maintenance factors for tissue-resident T cells that drive synapse elimination.
Title: Single-cell RNA transcriptome analysis of CNS immune cells reveals CXCL16/CXCR6 as maintenance factors for tissue-resident T cells that drive synapse elimination.
CXCL16 may be a predisposing factor to atherosclerosis: An animal study.
Title: CXCL16 may be a predisposing factor to atherosclerosis: An animal study.
Evolutionary analysis of chemokine CXCL16 and its receptor CXCR6 in murine rodents.
Title: Evolutionary analysis of chemokine CXCL16 and its receptor CXCR6 in murine rodents.
An immunomodulatory role for the Mycobacterium tuberculosis Acr protein in the formation of the tuberculous granuloma.
Title: An immunomodulatory role for the Mycobacterium tuberculosis Acr protein in the formation of the tuberculous granuloma.

Submit: New GeneRIF Correction See all GeneRIFs (61)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (8) 1 citation
Targeted (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chemokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables chemokine activity	IDA Inferred from Direct Assay more info	PubMed
enables chemokine activity	ISO Inferred from Sequence Orthology more info
enables chemokine receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables low-density lipoprotein particle receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables low-density lipoprotein particle receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables scavenger receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables scavenger receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in T cell chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell growth	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in receptor-mediated endocytosis	IEA Inferred from Electronic Annotation more info
involved_in response to cytokine	ISO Inferred from Sequence Orthology more info
involved_in response to tumor necrosis factor	IEA Inferred from Electronic Annotation more info
involved_in response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in response to type II interferon	IEA Inferred from Electronic Annotation more info
involved_in response to type II interferon	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: C-X-C motif chemokine 16

Names: Cxc chemokine ligand 16; SR-PSOX/CXCL16; chemokine (C-X-C motif) ligand 16; scavenger receptor for phosphatidylserine and oxidized low density lipoprotein; small-inducible cytokine B16; transmembrane chemokine CXCL16; zinc finger, MYND-type containing 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023158.7 → NP_075647.3 C-X-C motif chemokine 16 precursor

See identical proteins and their annotated locations for NP_075647.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the protein-coding transcript.

Source sequence(s)

AK028875, BE956848

Consensus CDS

CCDS24948.1

UniProtKB/Swiss-Prot

Q3UD70, Q5F2D5, Q8BSU2, Q8VE25, Q9EPB3

UniProtKB/TrEMBL

A2CFE9, I7HIQ2

Related

ENSMUSP00000019064.3, ENSMUST00000019064.9

Conserved Domains (1) summary

COG1429
Location:114 → 211

CobN; Cobalamin biosynthesis protein CobN, Mg-chelatase [Coenzyme transport and metabolism]

RNA

NR_151496.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) includes two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK028875, AK151330, BE956848, GQ380017

Related

ENSMUST00000154475.2
NR_151497.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains an alternate 3' terminal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK028875, AK030515
NR_151499.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) includes an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK028875, AK151330, BE956848, GQ380016