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    GLYATL1 glycine-N-acyltransferase like 1 [ Homo sapiens (human) ]

    Gene ID: 92292, updated on 10-Dec-2024

    Summary

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    Official Symbol
    GLYATL1provided by HGNC
    Official Full Name
    glycine-N-acyltransferase like 1provided by HGNC
    Primary source
    HGNC:HGNC:30519
    See related
    Ensembl:ENSG00000166840 MIM:614761; AllianceGenome:HGNC:30519
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GNAT; GATF-C
    Summary
    Enables glutamine N-acyltransferase activity. Involved in glutamine metabolic process. Predicted to be located in mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in kidney (RPKM 74.7), liver (RPKM 64.2) and 1 other tissue See more
    Orthologs
    all
    NEW
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    Genomic context

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    See GLYATL1 in Genome Data Viewer
    Location:
    11q12.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (58905481..58956406)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (58854982..58905920)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (58672954..58723879)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene translation machinery associated 16 homolog pseudogene 1 Neighboring gene glycine-N-acyltransferase like 2 Neighboring gene glycine-N-acyltransferase like 1 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:58672857-58673356 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:58694840-58695354 Neighboring gene uncharacterized LOC283194 Neighboring gene protein kinase cAMP-dependent type II regulatory subunit beta pseudogene Neighboring gene glycine-N-acyltransferase like 1 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Characterization of glycine-N-acyltransferase like 1 (GLYATL1) in prostate cancer. Eich ML, et al. Prostate, 2019 Oct. PMID 31376196
    2. Designation of enzyme activity of glycine-N-acyltransferase family genes and depression of glycine-N-acyltransferase in human hepatocellular carcinoma. Matsuo M, et al. Biochem Biophys Res Commun, 2012 Apr 20. PMID 22475485
    3. Severe Acute Respiratory Syndrome Coronavirus 2 ORF8 Protein Inhibits Type I Interferon Production by Targeting HSP90B1 Signaling. Chen J, et al. Front Cell Infect Microbiol, 2022. PMID 35677655, Free PMC Article
    4. Identification of proteins that interact with alpha A-crystallin using a human proteome microarray. Fan Q, et al. Mol Vis, 2014. PMID 24453475, Free PMC Article
    5. High-resolution photocatalytic mapping of SARS-CoV-2 spike interactions on the cell surface. Datta S, et al. Cell Chem Biol, 2023 Oct 19. PMID 37499664

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ26507, FLJ34646, FLJ60524, MGC15397, MGC15937

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables glutamine N-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutamine N-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycine N-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutamine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutamine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glycine N-acyltransferase-like protein 1
    Names
    acyl-CoA:glycine N-acyltransferase-like protein 1
    glutamine N-acyltransferase
    NP_001207423.1
    NP_001207425.1
    NP_001341628.1
    NP_001376640.1
    NP_001376641.1
    NP_001376642.1
    NP_001376643.1
    NP_001376644.1
    NP_001376645.1
    NP_001376646.1
    NP_001376647.1
    NP_542392.2
    XP_011543656.1
    XP_011543657.1
    XP_011543658.1
    XP_011543659.1
    XP_011543660.1
    XP_011543661.1
    XP_054226487.1
    XP_054226488.1
    XP_054226489.1
    XP_054226490.1
    XP_054226491.1
    XP_054226492.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001220494.4 → NP_001207423.1  glycine N-acyltransferase-like protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001207423.1

      Status: VALIDATED

      Source sequence(s)
      AP001636, AP001652, KF459756
      Consensus CDS
      CCDS55768.1
      UniProtKB/Swiss-Prot
      A6NDT0, Q7Z510, Q8NAW8, Q969I3
      UniProtKB/TrEMBL
      A9ZM15, B4DU33, E7ERD5
      Related
      ENSP00000322223.4, ENST00000317391.8
      Conserved Domains (2) summary
      pfam08444
      Location:208 → 296
      Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
      pfam06021
      Location:1 → 207
      Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase

    2. NM_001220496.4 → NP_001207425.1  glycine N-acyltransferase-like protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001207425.1

      Status: VALIDATED

      Source sequence(s)
      AP001636, KF459756
      Consensus CDS
      CCDS55768.1
      UniProtKB/Swiss-Prot
      A6NDT0, Q7Z510, Q8NAW8, Q969I3
      UniProtKB/TrEMBL
      A9ZM15, B4DU33, E7ERD5
      Related
      ENSP00000479741.1, ENST00000612196.1
      Conserved Domains (2) summary
      pfam08444
      Location:208 → 296
      Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
      pfam06021
      Location:1 → 207
      Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase

    3. NM_001354699.4 → NP_001341628.1  glycine N-acyltransferase-like protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AP001636, AP001652, KF459756
      Consensus CDS
      CCDS55768.1
      UniProtKB/Swiss-Prot
      A6NDT0, Q7Z510, Q8NAW8, Q969I3
      UniProtKB/TrEMBL
      A9ZM15, B4DU33, E7ERD5
      Conserved Domains (2) summary
      pfam08444
      Location:208 → 296
      Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
      pfam06021
      Location:1 → 207
      Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase

    4. NM_001389711.2 → NP_001376640.1  glycine N-acyltransferase-like protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AP001636, AP001652, KF459756
      Consensus CDS
      CCDS55768.1
      UniProtKB/Swiss-Prot
      A6NDT0, Q7Z510, Q8NAW8, Q969I3
      UniProtKB/TrEMBL
      A9ZM15, B4DU33, E7ERD5
      Conserved Domains (2) summary
      pfam08444
      Location:208 → 296
      Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
      pfam06021
      Location:1 → 207
      Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase

    5. NM_001389712.2 → NP_001376641.1  glycine N-acyltransferase-like protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AP001636, KF459756
      Consensus CDS
      CCDS55768.1
      UniProtKB/Swiss-Prot
      A6NDT0, Q7Z510, Q8NAW8, Q969I3
      UniProtKB/TrEMBL
      A9ZM15, B4DU33, E7ERD5
      Related
      ENSP00000436116.2, ENST00000532726.6
      Conserved Domains (2) summary
      pfam08444
      Location:208 → 296
      Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
      pfam06021
      Location:1 → 207
      Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase

    6. NM_001389713.2 → NP_001376642.1  glycine N-acyltransferase-like protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AP001636, KF459756
      Consensus CDS
      CCDS55768.1
      UniProtKB/Swiss-Prot
      A6NDT0, Q7Z510, Q8NAW8, Q969I3
      UniProtKB/TrEMBL
      A9ZM15, B4DU33, E7ERD5
      Conserved Domains (2) summary
      pfam08444
      Location:208 → 296
      Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
      pfam06021
      Location:1 → 207
      Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase

    7. NM_001389714.2 → NP_001376643.1  glycine N-acyltransferase-like protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AP001636, AP001652, KF459756
      Consensus CDS
      CCDS55768.1
      UniProtKB/Swiss-Prot
      A6NDT0, Q7Z510, Q8NAW8, Q969I3
      UniProtKB/TrEMBL
      A9ZM15, B4DU33, E7ERD5
      Conserved Domains (2) summary
      pfam08444
      Location:208 → 296
      Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
      pfam06021
      Location:1 → 207
      Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase

    8. NM_001389715.2 → NP_001376644.1  glycine N-acyltransferase-like protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AP001636, KF459756
      Consensus CDS
      CCDS55768.1
      UniProtKB/Swiss-Prot
      A6NDT0, Q7Z510, Q8NAW8, Q969I3
      UniProtKB/TrEMBL
      A9ZM15, B4DU33, E7ERD5
      Conserved Domains (2) summary
      pfam08444
      Location:208 → 296
      Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
      pfam06021
      Location:1 → 207
      Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase

    9. NM_001389716.2 → NP_001376645.1  glycine N-acyltransferase-like protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AP001636, KF459756
      Consensus CDS
      CCDS55768.1
      UniProtKB/Swiss-Prot
      A6NDT0, Q7Z510, Q8NAW8, Q969I3
      UniProtKB/TrEMBL
      A9ZM15, B4DU33, E7ERD5
      Conserved Domains (2) summary
      pfam08444
      Location:208 → 296
      Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
      pfam06021
      Location:1 → 207
      Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase

    10. NM_001389717.2 → NP_001376646.1  glycine N-acyltransferase-like protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AP001636, AP001652, KF459756
      Consensus CDS
      CCDS55768.1
      UniProtKB/Swiss-Prot
      A6NDT0, Q7Z510, Q8NAW8, Q969I3
      UniProtKB/TrEMBL
      A9ZM15, B4DU33, E7ERD5
      Conserved Domains (2) summary
      pfam08444
      Location:208 → 296
      Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
      pfam06021
      Location:1 → 207
      Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase

    11. NM_001389718.2 → NP_001376647.1  glycine N-acyltransferase-like protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AP001636, AP001652, KF459756
      Consensus CDS
      CCDS91475.1
      UniProtKB/TrEMBL
      A0A8I5KR82, B4DU33, E7ERD5
      Related
      ENSP00000510029.1, ENST00000685442.1
      Conserved Domains (2) summary
      pfam06021
      Location:1 → 166
      Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase
      cl17182
      Location:167 → 255
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

    12. NM_080661.6 → NP_542392.2  glycine N-acyltransferase-like protein 1 isoform 1

      See identical proteins and their annotated locations for NP_542392.2

      Status: VALIDATED

      Source sequence(s)
      AP001636, KF459756
      Consensus CDS
      CCDS31556.1
      UniProtKB/Swiss-Prot
      Q969I3
      Related
      ENSP00000300079.5, ENST00000300079.9
      Conserved Domains (2) summary
      pfam08444
      Location:239 → 327
      Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
      pfam06021
      Location:51 → 238
      Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      58905481..58956406
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011545357.3 → XP_011543659.1  glycine N-acyltransferase-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011543659.1

      UniProtKB/TrEMBL
      A0A8I5KVG3
      Conserved Domains (2) summary
      pfam08444
      Location:231 → 319
      Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
      pfam06021
      Location:43 → 230
      Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase

    2. XM_011545355.3 → XP_011543657.1  glycine N-acyltransferase-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011543657.1

      UniProtKB/TrEMBL
      A0A8I5KVG3
      Conserved Domains (2) summary
      pfam08444
      Location:231 → 319
      Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
      pfam06021
      Location:43 → 230
      Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase

    3. XM_011545356.3 → XP_011543658.1  glycine N-acyltransferase-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011543658.1

      UniProtKB/TrEMBL
      A0A8I5KVG3
      Conserved Domains (2) summary
      pfam08444
      Location:231 → 319
      Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
      pfam06021
      Location:43 → 230
      Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase

    4. XM_011545354.3 → XP_011543656.1  glycine N-acyltransferase-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011543656.1

      UniProtKB/TrEMBL
      A0A8I5KVG3
      Related
      ENSP00000508694.1, ENST00000689150.1
      Conserved Domains (2) summary
      pfam08444
      Location:231 → 319
      Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
      pfam06021
      Location:43 → 230
      Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase

    5. XM_011545358.4 → XP_011543660.1  glycine N-acyltransferase-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011543660.1

      UniProtKB/TrEMBL
      A0A8I5KVG3
      Conserved Domains (2) summary
      pfam08444
      Location:231 → 319
      Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
      pfam06021
      Location:43 → 230
      Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase

    6. XM_011545359.3 → XP_011543661.1  glycine N-acyltransferase-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011543661.1

      UniProtKB/TrEMBL
      A0A8I5KVG3
      Conserved Domains (2) summary
      pfam08444
      Location:231 → 319
      Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
      pfam06021
      Location:43 → 230
      Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      58854982..58905920
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054370515.1 → XP_054226490.1  glycine N-acyltransferase-like protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5KVG3

    2. XM_054370513.1 → XP_054226488.1  glycine N-acyltransferase-like protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5KVG3

    3. XM_054370514.1 → XP_054226489.1  glycine N-acyltransferase-like protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5KVG3

    4. XM_054370512.1 → XP_054226487.1  glycine N-acyltransferase-like protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5KVG3

    5. XM_054370516.1 → XP_054226491.1  glycine N-acyltransferase-like protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5KVG3

    6. XM_054370517.1 → XP_054226492.1  glycine N-acyltransferase-like protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5KVG3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q969I3.1 GenPept UniProtKB/Swiss-Prot:Q969I3

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