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    Armh3 armadillo-like helical domain containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 71617, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Armh3provided by MGI
    Official Full Name
    armadillo-like helical domain containing 3provided by MGI
    Primary source
    MGI:MGI:1918867
    See related
    Ensembl:ENSMUSG00000039901 AllianceGenome:MGI:1918867
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9130011E15Rik
    Summary
    Predicted to be involved in regulation of Golgi organization. Predicted to be located in Golgi membrane. Predicted to be active in cytosol. Is expressed in heart. Orthologous to human ARMH3 (armadillo like helical domain containing 3). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in heart adult (RPKM 5.9), whole brain E14.5 (RPKM 5.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Armh3 in Genome Data Viewer
    Location:
    19 C3; 19 38.75 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (45805799..45987071, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (45817362..45998632, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4286 Neighboring gene O-GlcNAcase Neighboring gene STARR-seq mESC enhancer starr_46285 Neighboring gene Kv channel-interacting protein 2 Neighboring gene STARR-seq mESC enhancer starr_46286 Neighboring gene STARR-positive B cell enhancer ABC_E7665 Neighboring gene STARR-seq mESC enhancer starr_46288 Neighboring gene ribosomal protein L21 pseudogene Neighboring gene STARR-seq mESC enhancer starr_46291 Neighboring gene RIKEN cDNA 4930505N22 gene Neighboring gene STARR-positive B cell enhancer ABC_E4287 Neighboring gene HPS6, biogenesis of lysosomal organelles complex 2 subunit 3 Neighboring gene STARR-seq mESC enhancer starr_46294 Neighboring gene STARR-positive B cell enhancer ABC_E5707 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:46114769-46114954 Neighboring gene LIM domain binding 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ARMH3-mediated recruitment of PI4KB directs Golgi-to-endosome trafficking and activation of the antiviral effector STING. Fang R, et al. Immunity, 2023 Mar 14. PMID 36921576
    2. Armadillo-like helical domain containing-4 is dynamically expressed in both the first and second heart fields. Conway SJ, et al. Gene Expr Patterns, 2019 Dec. PMID 31655130, Free PMC Article
    3. TRF2-mediated telomere protection is dispensable in pluripotent stem cells. Markiewicz-Potoczny M, et al. Nature, 2021 Jan. PMID 33239785, Free PMC Article
    4. Placentation defects are highly prevalent in embryonic lethal mouse mutants. Perez-Garcia V, et al. Nature, 2018 Mar 22. PMID 29539633, Free PMC Article
    5. Identification of atrogin-1-targeted proteins during the myostatin-induced skeletal muscle wasting. Lokireddy S, et al. Am J Physiol Cell Physiol, 2012 Sep 1. PMID 22673621

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ARMH3-mediated recruitment of PI4KB directs Golgi-to-endosome trafficking and activation of the antiviral effector STING.
      Title: ARMH3-mediated recruitment of PI4KB directs Golgi-to-endosome trafficking and activation of the antiviral effector STING.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of Golgi organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    armadillo-like helical domain-containing protein 3
    Names
    UPF0668 protein C10orf76 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198296.2 → NP_938038.2  armadillo-like helical domain-containing protein 3

      Status: VALIDATED

      Source sequence(s)
      AK159765, BC058989
      Consensus CDS
      CCDS50454.1
      UniProtKB/Swiss-Prot
      Q3TWB1, Q6PD19, Q80V50
      Related
      ENSMUSP00000048454.8, ENSMUST00000045396.9
      Conserved Domains (1) summary
      pfam08427
      Location:441 → 669
      DUF1741; Domain of unknown function (DUF1741)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      45805799..45987071 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161692.1 → XP_036017585.1  armadillo-like helical domain-containing protein 3 isoform X2

      Conserved Domains (1) summary
      pfam08427
      Location:441 → 642
      DUF1741; Domain of unknown function (DUF1741)

    2. XM_011247345.3 → XP_011245647.1  armadillo-like helical domain-containing protein 3 isoform X1

      UniProtKB/Swiss-Prot
      Q3TWB1, Q6PD19, Q80V50
      Conserved Domains (1) summary
      pfam08427
      Location:441 → 669
      DUF1741; Domain of unknown function (DUF1741)

    3. XM_036161693.1 → XP_036017586.1  armadillo-like helical domain-containing protein 3 isoform X2

      Conserved Domains (1) summary
      pfam08427
      Location:441 → 642
      DUF1741; Domain of unknown function (DUF1741)

    4. XM_006527344.5 → XP_006527407.1  armadillo-like helical domain-containing protein 3 isoform X3

      Conserved Domains (1) summary
      pfam08427
      Location:441 → 594
      DUF1741; Domain of unknown function (DUF1741)

    RNA

    1. XR_386511.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PD19.2 GenPept UniProtKB/Swiss-Prot:Q6PD19

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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