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    fur ferric uptake regulation protein [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 881780, updated on 11-Sep-2024

    Summary

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    Gene symbol
    fur
    Gene description
    ferric uptake regulation protein
    Locus tag
    PA4764
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (5351675..5352079, complement)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene heat shock protein GrpE Neighboring gene DNA repair protein RecN Neighboring gene outer membrane lipoprotein OmlA Neighboring gene hypothetical protein Neighboring gene hypothetical protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mechanistic insights into metal ion activation and operator recognition by the ferric uptake regulator. Deng Z, et al. Nat Commun, 2015 Jul 2. PMID 26134419, Free PMC Article
    2. Role of the ferric uptake regulator of Pseudomonas aeruginosa in the regulation of siderophores and exotoxin A expression: purification and activity on iron-regulated promoters. Ochsner UA, et al. J Bacteriol, 1995 Dec. PMID 8522528, Free PMC Article
    3. Ferric uptake regulator (Fur) mutants of Pseudomonas aeruginosa demonstrate defective siderophore-mediated iron uptake, altered aerobic growth, and decreased superoxide dismutase and catalase activities. Hassett DJ, et al. J Bacteriol, 1996 Jul. PMID 8763923, Free PMC Article
    4. Ferric uptake regulator mutants of Pseudomonas aeruginosa with distinct alterations in the iron-dependent repression of exotoxin A and siderophores in aerobic and microaerobic environments. Barton HA, et al. Mol Microbiol, 1996 Sep. PMID 8885270
    5. An operon containing fumC and sodA encoding fumarase C and manganese superoxide dismutase is controlled by the ferric uptake regulator in Pseudomonas aeruginosa: fur mutants produce elevated alginate levels. Hassett DJ, et al. J Bacteriol, 1997 Mar. PMID 9045799, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. findings showed that Fur is dispensable for planktonic growth, while it is required for colony formation; this is because Fur protects P. aeruginosa colonies from toxicity exerted by the pyochelin siderophore
      Title: Ferric Uptake Regulator Fur Is Conditionally Essential in Pseudomonas aeruginosa.
    2. Fur recognizes DNA by using a combination of base readout through direct contacts in the major groove and shape readout through recognition of the minor-groove electrostatic potential by lysine.
      Title: Mechanistic insights into metal ion activation and operator recognition by the ferric uptake regulator.
    3. Gln60Pro amino acid replacement in the regulatory Fur protein is responsible for the overproduction of pyoverdine in iron-deplete and iron-replete medium.
      Title: Effect of the amino acid substitution in the DNA-binding domain of the Fur regulator on production of pyoverdine.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Function Evidence Code Pubs
    enables ferrous iron binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of lyase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of siderophore biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of peroxidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of superoxide dismutase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ferric uptake regulation protein
    NP_253452.1
    • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      5351675..5352079 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_253452.1 ferric uptake regulation protein [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_253452.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A367LX59
      Conserved Domains (1) summary
      cl21459
      Location:4 → 129
      HTH; Helix-turn-helix domains
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03456.1

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