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    SIRPA signal regulatory protein alpha [ Homo sapiens (human) ]

    Gene ID: 140885, updated on 4-Jan-2025

    Summary

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    Official Symbol
    SIRPAprovided by HGNC
    Official Full Name
    signal regulatory protein alphaprovided by HGNC
    Primary source
    HGNC:HGNC:9662
    See related
    Ensembl:ENSG00000198053 MIM:602461; AllianceGenome:HGNC:9662
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BIT; MFR; P84; SIRP; MYD-1; SHPS1; CD172A; PTPNS1
    Summary
    The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 71.2), appendix (RPKM 27.2) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SIRPA in Genome Data Viewer
    Location:
    20p13
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (1894167..1940592)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (1924358..1970769)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (1874813..1921238)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:1809920-1810830 Neighboring gene uncharacterized LOC105372501 Neighboring gene uncharacterized LOC124904857 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17460 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:1856587-1857086 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:1859821-1860322 Neighboring gene uncharacterized LOC102724545 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:1871108-1871632 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12595 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12596 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:1876698-1877213 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:1880839-1881408 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:1882505-1883004 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12597 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:1917714-1918268 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:1918269-1918821 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:1920335-1920836 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:1920837-1921336 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:1926175-1926721 Neighboring gene Sharpr-MPRA regulatory region 9993 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:1928155-1928702 Neighboring gene Sharpr-MPRA regulatory region 1230 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17462 Neighboring gene PDYN antisense RNA 1 Neighboring gene NANOG hESC enhancer GRCh37_chr20:1945208-1945758 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:1974244-1975074 Neighboring gene Sharpr-MPRA regulatory region 7514 Neighboring gene prodynorphin Neighboring gene ribosomal protein L7 pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Neutrophil apoptosis is associated with loss of signal regulatory protein alpha (SIRPα) from the cell surface. Stenberg A, et al. J Leukoc Biol, 2013 Mar. PMID 23271705
    2. Semimature stage: a checkpoint in a dendritic cell maturation program that allows for functional reversion after signal-regulatory protein-alpha ligation and maturation signals. Braun D, et al. J Immunol, 2006 Dec 15. PMID 17142753
    3. Impact of SIRPα polymorphism on transplant outcomes in HLA-identical living donor kidney transplantation. Garcia-Sanchez C, et al. Clin Transplant, 2021 Sep. PMID 34180101
    4. SIRPalpha1 and SIRPalpha2: their role as tumor suppressors in breast carcinoma cells. Yamasaki Y, et al. Biochem Biophys Res Commun, 2007 Sep 14. PMID 17632076
    5. Clinical significance of signal regulatory protein alpha (SIRPα) expression in esophageal squamous cell carcinoma. Koga N, et al. Cancer Sci, 2021 Aug. PMID 34009732, Free PMC Article

    See all (157) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The expression of signal regulatory protein alpha (SIRPalpha) in periodontal cells and tissue.
      Title: The expression of signal regulatory protein alpha (SIRPα) in periodontal cells and tissue.
    2. Podocyte SIRPalpha reduction aggravates lupus nephritis via promoting T cell inflammatory responses.
      Title: Podocyte SIRPα reduction aggravates lupus nephritis via promoting T cell inflammatory responses.
    3. Surfactant protein D prevents mucin overproduction in airway goblet cells via SIRPalpha.
      Title: Surfactant protein D prevents mucin overproduction in airway goblet cells via SIRPα.
    4. Anti-tumor effect of PTEN and its effect on inhibition of the bone tumor through the CD47-SIRPalpha signaling pathway.
      Title: Anti-tumor effect of PTEN and its effect on inhibition of the bone tumor through the CD47-SIRPα signaling pathway.
    5. A mAb to SIRPalpha downregulates the priming of naive CD4 + T cell in Primary immune thrombocytopenia.
      Title: A mAb to SIRPα downregulates the priming of naive CD4 + T cell in Primary immune thrombocytopenia.
    6. SIRP-alpha-IL-6 axis induces immunosuppressive macrophages in non-small-cell lung cancer.
      Title: SIRP-alpha-IL-6 axis induces immunosuppressive macrophages in non-small-cell lung cancer.
    7. Clinical Significance of Signal Regulatory Protein Alpha (SIRPalpha) Expression in Hepatocellular Carcinoma.
      Title: Clinical Significance of Signal Regulatory Protein Alpha (SIRPα) Expression in Hepatocellular Carcinoma.
    8. Clinical significance of signal regulatory protein alpha and T cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibition motif domain expression in undifferentiated pleomorphic sarcoma.
      Title: Clinical significance of signal regulatory protein alpha and T cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibition motif domain expression in undifferentiated pleomorphic sarcoma.
    9. Thrombospondin-1, CD47, and SIRPalpha display cell-specific molecular signatures in human islets and pancreata.
      Title: Thrombospondin-1, CD47, and SIRPα display cell-specific molecular signatures in human islets and pancreata.
    10. Loss of myeloid cell-specific SIRPalpha, but not CD47, attenuates inflammation and suppresses atherosclerosis.
      Title: Loss of myeloid cell-specific SIRPα, but not CD47, attenuates inflammation and suppresses atherosclerosis.
    Submit: New GeneRIF Correction See all GeneRIFs (101)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.
    EBI GWAS Catalog
    Genome-wide association study of liver enzymes in korean children.
    EBI GWAS Catalog
    Genome-wide joint SNP and CNV analysis of aortic root diameter in African Americans: the HyperGEN study.
    EBI GWAS Catalog
    New gene functions in megakaryopoiesis and platelet formation.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cell-cell adhesion mediator activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein antigen binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding involved in heterotypic cell-cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein phosphatase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein phosphatase inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein tyrosine kinase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to hydrogen peroxide ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to interleukin-1 ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to interleukin-12 IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to type II interferon ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in heterotypic cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monocyte extravasation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of JNK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of canonical NF-kappaB signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of chemokine (C-C motif) ligand 5 production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of cytokine production involved in inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of interferon-beta production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of interleukin-6 production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of lipopolysaccharide-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of macrophage inflammatory protein 1 alpha production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of nitric oxide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of phagocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of tumor necrosis factor production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of T cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of phagocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of reactive oxygen species metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of interleukin-1 beta production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of interleukin-6 production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of nitric oxide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of tumor necrosis factor production IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of tumor necrosis factor production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of type II interferon production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cell surface TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in ficolin-1-rich granule membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in tertiary granule membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    tyrosine-protein phosphatase non-receptor type substrate 1
    Names
    CD172 antigen-like family member A
    brain-immunoglobulin-like molecule with tyrosine-based activation motifs
    inhibitory receptor SHPS-1
    macrophage fusion receptor
    myd-1 antigen
    tyrosine phosphatase SHP substrate 1
    NP_001035111.1
    NP_001035112.1
    NP_001317657.1
    NP_542970.1
    XP_005260727.1
    XP_011527475.1
    XP_024307604.1
    XP_047295871.1
    XP_047295872.1
    XP_047295873.1
    XP_047295874.1
    XP_047295875.1
    XP_047295876.1
    XP_054179022.1
    XP_054179023.1
    XP_054179024.1
    XP_054179025.1
    XP_054179026.1
    XP_054179027.1
    XP_054179028.1
    XP_054179029.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040022.1 → NP_001035111.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) uses an alternate, in-frame, splice donor site in the 3' coding region compared to variant 4. This variant encodes a shorter protein (isoform 1) compared to isoform 2. Variants 1, 2, and 3 encode the same protein (isoform 1).
      Source sequence(s)
      AL034562, BC075849, DA471662, DN989886
      Consensus CDS
      CCDS13022.1
      UniProtKB/Swiss-Prot
      A2A2E1, A8K411, B2R6C3, O00683, O43799, P78324, Q8N517, Q8TAL8, Q9H0Z2, Q9UDX2, Q9UIJ6, Q9Y4U9
      UniProtKB/TrEMBL
      B4DP97
      Related
      ENSP00000382941.4, ENST00000400068.7
      Conserved Domains (4) summary
      cd00098
      Location:266 → 339
      IgC; Immunoglobulin Constant domain
      smart00410
      Location:41 → 144
      IG_like; Immunoglobulin like
      pfam07686
      Location:38 → 145
      V-set; Immunoglobulin V-set domain
      cl11960
      Location:143 → 254
      Ig; Immunoglobulin domain

    2. NM_001040023.2 → NP_001035112.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate, in-frame, splice donor site in the 3' coding region compared to variant 4. This variant encodes a shorter protein (isoform 1) compared to isoform 2. Variants 1, 2, and 3 encode the same protein (isoform 1).
      Source sequence(s)
      AL034562, BC038510, DN989886
      Consensus CDS
      CCDS13022.1
      UniProtKB/Swiss-Prot
      A2A2E1, A8K411, B2R6C3, O00683, O43799, P78324, Q8N517, Q8TAL8, Q9H0Z2, Q9UDX2, Q9UIJ6, Q9Y4U9
      UniProtKB/TrEMBL
      B4DP97
      Related
      ENSP00000351621.4, ENST00000358771.5
      Conserved Domains (4) summary
      cd00098
      Location:266 → 339
      IgC; Immunoglobulin Constant domain
      smart00410
      Location:41 → 144
      IG_like; Immunoglobulin like
      pfam07686
      Location:38 → 145
      V-set; Immunoglobulin V-set domain
      cl11960
      Location:143 → 254
      Ig; Immunoglobulin domain

    3. NM_001330728.1 → NP_001317657.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) encodes the longer protein (isoform 2).
      Source sequence(s)
      AL034562, BC026692, BC033092, DA471662, DN989886
      Consensus CDS
      CCDS82593.1
      UniProtKB/TrEMBL
      B4DP97
      Related
      ENSP00000478763.1, ENST00000622179.4
      Conserved Domains (3) summary
      cd05772
      Location:147 → 250
      IgC_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2
      cd16085
      Location:252 → 355
      IgC_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3
      cd16097
      Location:35 → 145
      IgV_SIRP; Immunoglobulin (Ig)-like domain of Signal-Regulatory Protein (SIRP)

    4. NM_080792.3 → NP_542970.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate, in-frame, splice donor site in the 3' coding region compared to variant 4. This variant encodes a shorter protein (isoform 1) compared to isoform 2. Variants 1, 2, and 3 encode the same protein (isoform 1).
      Source sequence(s)
      AB023430, AL034562, AL117335
      Consensus CDS
      CCDS13022.1
      UniProtKB/Swiss-Prot
      A2A2E1, A8K411, B2R6C3, O00683, O43799, P78324, Q8N517, Q8TAL8, Q9H0Z2, Q9UDX2, Q9UIJ6, Q9Y4U9
      UniProtKB/TrEMBL
      B4DP97
      Related
      ENSP00000348307.3, ENST00000356025.7
      Conserved Domains (4) summary
      cd00098
      Location:266 → 339
      IgC; Immunoglobulin Constant domain
      smart00410
      Location:41 → 144
      IG_like; Immunoglobulin like
      pfam07686
      Location:38 → 145
      V-set; Immunoglobulin V-set domain
      cl11960
      Location:143 → 254
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      1894167..1940592
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047439917.1 → XP_047295873.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X4

    2. XM_047439919.1 → XP_047295875.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X5

    3. XM_005260670.4 → XP_005260727.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X1

      UniProtKB/TrEMBL
      B4DP97
      Conserved Domains (3) summary
      cd05772
      Location:147 → 250
      IgC_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2
      cd16085
      Location:252 → 355
      IgC_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3
      cd16097
      Location:35 → 145
      IgV_SIRP; Immunoglobulin (Ig)-like domain of Signal-Regulatory Protein (SIRP)

    4. XM_024451836.2 → XP_024307604.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X1

      UniProtKB/TrEMBL
      B4DP97
      Conserved Domains (3) summary
      cd05772
      Location:147 → 250
      IgC_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2
      cd16085
      Location:252 → 355
      IgC_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3
      cd16097
      Location:35 → 145
      IgV_SIRP; Immunoglobulin (Ig)-like domain of Signal-Regulatory Protein (SIRP)

    5. XM_047439916.1 → XP_047295872.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X3

      UniProtKB/Swiss-Prot
      A2A2E1, A8K411, B2R6C3, O00683, O43799, P78324, Q8N517, Q8TAL8, Q9H0Z2, Q9UDX2, Q9UIJ6, Q9Y4U9
      UniProtKB/TrEMBL
      B4DP97

    6. XM_047439918.1 → XP_047295874.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X4

    7. XM_047439920.1 → XP_047295876.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X5

    8. XM_047439915.1 → XP_047295871.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X2

      UniProtKB/TrEMBL
      B4DP97

    9. XM_011529173.3 → XP_011527475.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X2

      UniProtKB/TrEMBL
      B4DP97
      Conserved Domains (4) summary
      cd00098
      Location:266 → 339
      IgC; Immunoglobulin Constant domain
      smart00410
      Location:41 → 122
      IG_like; Immunoglobulin like
      pfam07686
      Location:38 → 145
      V-set; Immunoglobulin V-set domain
      cl11960
      Location:143 → 254
      Ig; Immunoglobulin domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      1924358..1970769
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054323051.1 → XP_054179026.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X4

    2. XM_054323053.1 → XP_054179028.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X5

    3. XM_054323047.1 → XP_054179022.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X1

      UniProtKB/TrEMBL
      B4DP97

    4. XM_054323052.1 → XP_054179027.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X4

    5. XM_054323048.1 → XP_054179023.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X1

      UniProtKB/TrEMBL
      B4DP97

    6. XM_054323050.1 → XP_054179025.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X3

      UniProtKB/TrEMBL
      B4DP97

    7. XM_054323054.1 → XP_054179029.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X5

    8. XM_054323049.1 → XP_054179024.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X2

      UniProtKB/TrEMBL
      B4DP97
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P78324.2 GenPept UniProtKB/Swiss-Prot:P78324

    Gene LinkOut

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