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    Sgms1 sphingomyelin synthase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 353229, updated on 3-Dec-2024

    Summary

    Official Symbol
    Sgms1provided by RGD
    Official Full Name
    sphingomyelin synthase 1provided by RGD
    Primary source
    RGD:727912
    See related
    EnsemblRapid:ENSRNOG00000012536 AllianceGenome:RGD:727912
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mob; mob-1; Tmem23
    Summary
    Predicted to enable ceramide cholinephosphotransferase activity; ceramide phosphoethanolamine synthase activity; and sphingomyelin synthase activity. Involved in cellular response to lipopolysaccharide; cellular response to tumor necrosis factor; and positive regulation of gene expression. Predicted to be located in Golgi trans cisterna. Predicted to be active in Golgi membrane; endoplasmic reticulum membrane; and plasma membrane. Used to study pulmonary edema. Biomarker of pulmonary edema. Orthologous to human SGMS1 (sphingomyelin synthase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 378.2), Kidney (RPKM 279.5) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Sgms1 in Genome Data Viewer
    Location:
    1q52
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (239409991..239681195, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (229996673..230259591, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (250692448..250951685, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene APOBEC1 complementation factor Neighboring gene N-acylsphingosine amidohydrolase 2 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene nuclear transport factor 2, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC93062

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ceramide cholinephosphotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ceramide cholinephosphotransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ceramide cholinephosphotransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ceramide phosphoethanolamine synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphotransferase activity, for other substituted phosphate groups IEA
    Inferred from Electronic Annotation
    more info
     
    enables sphingomyelin synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sphingomyelin synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables sphingomyelin synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to tumor necrosis factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in ceramide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within ceramide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in sphingomyelin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sphingomyelin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sphingomyelin biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in Golgi trans cisterna ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    phosphatidylcholine:ceramide cholinephosphotransferase 1
    Names
    protein Mob
    transmembrane protein 23
    NP_852051.2
    XP_038936909.1
    XP_038936911.1
    XP_038936916.1
    XP_038936922.1
    XP_038936925.1
    XP_038936926.1
    XP_038936929.1
    XP_038936937.1
    XP_038936942.1
    XP_038936946.1
    XP_063121795.1
    XP_063121800.1
    XP_063121802.1
    XP_063121807.1
    XP_063121810.1
    XP_063121813.1
    XP_063121819.1
    XP_063121824.1
    XP_063121829.1
    XP_063121834.1
    XP_063121837.1
    XP_063121840.1
    XP_063121846.1
    XP_063121847.1
    XP_063121851.1
    XP_063121856.1
    XP_063121860.1
    XP_063121863.1
    XP_063121867.1
    XP_063121876.1
    XP_063121886.1
    XP_063121889.1
    XP_063121892.1
    XP_063121893.1
    XP_063121901.1
    XP_063121906.1
    XP_063121908.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181386.3NP_852051.2  phosphatidylcholine:ceramide cholinephosphotransferase 1

      See identical proteins and their annotated locations for NP_852051.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q7TSX5
      UniProtKB/TrEMBL
      A6I104
      Conserved Domains (2) summary
      cd09514
      Location:778
      SAM_SGMS1; SAM domain of sphingomyelin synthase
      pfam14360
      Location:282355
      PAP2_C; PAP2 superfamily C-terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      239409991..239681195 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265797.1XP_063121867.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q7TSX5
      UniProtKB/TrEMBL
      A6I104
    2. XM_063265725.1XP_063121795.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q7TSX5
      UniProtKB/TrEMBL
      A6I104
    3. XM_063265790.1XP_063121860.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q7TSX5
      UniProtKB/TrEMBL
      A6I104
    4. XM_063265754.1XP_063121824.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q7TSX5
      UniProtKB/TrEMBL
      A6I104
    5. XM_063265770.1XP_063121840.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q7TSX5
      UniProtKB/TrEMBL
      A6I104
    6. XM_063265743.1XP_063121813.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q7TSX5
      UniProtKB/TrEMBL
      A6I104
    7. XM_039080997.2XP_038936925.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q7TSX5
      UniProtKB/TrEMBL
      A6I104
      Conserved Domains (2) summary
      cd09514
      Location:778
      SAM_SGMS1; SAM domain of sphingomyelin synthase
      pfam14360
      Location:282355
      PAP2_C; PAP2 superfamily C-terminal
    8. XM_039080981.2XP_038936909.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q7TSX5
      UniProtKB/TrEMBL
      A6I104
      Conserved Domains (2) summary
      cd09514
      Location:778
      SAM_SGMS1; SAM domain of sphingomyelin synthase
      pfam14360
      Location:282355
      PAP2_C; PAP2 superfamily C-terminal
    9. XM_063265737.1XP_063121807.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q7TSX5
      UniProtKB/TrEMBL
      A6I104
    10. XM_039080994.2XP_038936922.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q7TSX5
      UniProtKB/TrEMBL
      A6I104
      Conserved Domains (2) summary
      cd09514
      Location:778
      SAM_SGMS1; SAM domain of sphingomyelin synthase
      pfam14360
      Location:282355
      PAP2_C; PAP2 superfamily C-terminal
    11. XM_063265730.1XP_063121800.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q7TSX5
      UniProtKB/TrEMBL
      A6I104
    12. XM_063265732.1XP_063121802.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q7TSX5
      UniProtKB/TrEMBL
      A6I104
    13. XM_063265759.1XP_063121829.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q7TSX5
      UniProtKB/TrEMBL
      A6I104
    14. XM_063265767.1XP_063121837.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q7TSX5
      UniProtKB/TrEMBL
      A6I104
    15. XM_063265793.1XP_063121863.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q7TSX5
      UniProtKB/TrEMBL
      A6I104
    16. XM_063265764.1XP_063121834.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q7TSX5
      UniProtKB/TrEMBL
      A6I104
    17. XM_039080983.2XP_038936911.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q7TSX5
      UniProtKB/TrEMBL
      A6I104
      Conserved Domains (2) summary
      cd09514
      Location:778
      SAM_SGMS1; SAM domain of sphingomyelin synthase
      pfam14360
      Location:282355
      PAP2_C; PAP2 superfamily C-terminal
    18. XM_039080988.2XP_038936916.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q7TSX5
      UniProtKB/TrEMBL
      A6I104
      Conserved Domains (2) summary
      cd09514
      Location:778
      SAM_SGMS1; SAM domain of sphingomyelin synthase
      pfam14360
      Location:282355
      PAP2_C; PAP2 superfamily C-terminal
    19. XM_063265781.1XP_063121851.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q7TSX5
      UniProtKB/TrEMBL
      A6I104
    20. XM_063265776.1XP_063121846.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q7TSX5
      UniProtKB/TrEMBL
      A6I104
    21. XM_063265777.1XP_063121847.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q7TSX5
      UniProtKB/TrEMBL
      A6I104
    22. XM_063265740.1XP_063121810.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q7TSX5
      UniProtKB/TrEMBL
      A6I104
    23. XM_063265786.1XP_063121856.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q7TSX5
      UniProtKB/TrEMBL
      A6I104
    24. XM_063265749.1XP_063121819.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q7TSX5
      UniProtKB/TrEMBL
      A6I104
    25. XM_039080998.2XP_038936926.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q7TSX5
      UniProtKB/TrEMBL
      A6I104
      Conserved Domains (2) summary
      cd09514
      Location:778
      SAM_SGMS1; SAM domain of sphingomyelin synthase
      pfam14360
      Location:282355
      PAP2_C; PAP2 superfamily C-terminal
    26. XM_039081001.2XP_038936929.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q7TSX5
      UniProtKB/TrEMBL
      A6I104
      Related
      ENSRNOP00000051643.1, ENSRNOT00000054761.3
      Conserved Domains (2) summary
      cd09514
      Location:778
      SAM_SGMS1; SAM domain of sphingomyelin synthase
      pfam14360
      Location:282355
      PAP2_C; PAP2 superfamily C-terminal
    27. XM_039081009.2XP_038936937.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q7TSX5
      UniProtKB/TrEMBL
      A6I104
      Conserved Domains (2) summary
      cd09514
      Location:778
      SAM_SGMS1; SAM domain of sphingomyelin synthase
      pfam14360
      Location:282355
      PAP2_C; PAP2 superfamily C-terminal
    28. XM_063265806.1XP_063121876.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X2

    29. XM_063265838.1XP_063121908.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JYM5, A6I105
    30. XM_063265836.1XP_063121906.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JYM5, A6I105
    31. XM_063265822.1XP_063121892.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JYM5, A6I105
    32. XM_063265816.1XP_063121886.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JYM5, A6I105
    33. XM_039081014.2XP_038936942.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JYM5, A6I105
      Conserved Domains (1) summary
      cd09514
      Location:778
      SAM_SGMS1; SAM domain of sphingomyelin synthase
    34. XM_063265819.1XP_063121889.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JYM5, A6I105
    35. XM_063265823.1XP_063121893.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JYM5, A6I105
    36. XM_063265831.1XP_063121901.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JYM5, A6I105
    37. XM_039081018.2XP_038936946.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X5

      UniProtKB/TrEMBL
      A0A0G2JYM5, A6I105
      Conserved Domains (1) summary
      cd09514
      Location:778
      SAM_SGMS1; SAM domain of sphingomyelin synthase

    RNA

    1. XR_005487755.2 RNA Sequence

    2. XR_010053998.1 RNA Sequence

    3. XR_010054000.1 RNA Sequence

    4. XR_010053999.1 RNA Sequence

    5. XR_010054001.1 RNA Sequence