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    Card11 caspase recruitment domain family, member 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100363332, updated on 3-Dec-2024

    Summary

    Official Symbol
    Card11provided by RGD
    Official Full Name
    caspase recruitment domain family, member 11provided by RGD
    Primary source
    RGD:2323211
    See related
    EnsemblRapid:ENSRNOG00000024277 AllianceGenome:RGD:2323211
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable CARD domain binding activity. Predicted to be involved in several processes, including intracellular signal transduction; positive regulation of NF-kappaB transcription factor activity; and positive regulation of signal transduction. Predicted to act upstream of or within several processes, including lymphocyte differentiation; positive regulation of interleukin-2 production; and regulation of lymphocyte activation. Predicted to be located in cytoplasm; immunological synapse; and membrane raft. Predicted to be part of CBM complex. Human ortholog(s) of this gene implicated in diffuse large B-cell lymphoma; immunodeficiency 11A; and immunodeficiency 11B. Orthologous to human CARD11 (caspase recruitment domain family member 11). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 141.6), Thymus (RPKM 53.8) and 3 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Card11 in Genome Data Viewer
    Location:
    12q11
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (18735088..18872045)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (13621140..13758115)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (15700600..15844512)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095893 Neighboring gene uncharacterized LOC102547234 Neighboring gene G protein subunit alpha 12 Neighboring gene archaelysin family metallopeptidase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables CARD domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of CD4-positive, alpha-beta T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of T cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within T cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in T cell costimulation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within homeostasis of number of cells ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lymphocyte activation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of CD4-positive, alpha-beta T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of T cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of T cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of interleukin-2 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-2 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of immune response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within thymic T cell selection ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of CBM complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in immunological synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in immunological synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    caspase recruitment domain-containing protein 11

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419863.1NP_001406792.1  caspase recruitment domain-containing protein 11

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A0A8I5ZNJ6, A0A8I6AA96
      Related
      ENSRNOP00000079664.1, ENSRNOT00000092970.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      18735088..18872045
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089959.2XP_038945887.1  caspase recruitment domain-containing protein 11 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZNJ6, A0A8I6AA96
      Conserved Domains (4) summary
      COG1196
      Location:127435
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00992
      Location:680752
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd08808
      Location:22107
      CARD_CARD11_CARMA1; Caspase activation and recruitment domain of CARD11-like proteins
      cl17036
      Location:777839
      SH3; Src Homology 3 domain superfamily