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    Rffl ring finger and FYVE-like domain containing E3 ubiquitin protein ligase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 282844, updated on 3-Dec-2024

    Summary

    Official Symbol
    Rfflprovided by RGD
    Official Full Name
    ring finger and FYVE-like domain containing E3 ubiquitin protein ligaseprovided by RGD
    Primary source
    RGD:727916
    See related
    EnsemblRapid:ENSRNOG00000007596 AllianceGenome:RGD:727916
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable enzyme binding activity; p53 binding activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis; negative regulation of signal transduction; and protein K48-linked ubiquitination. Predicted to act upstream of or within intracellular protein transport. Predicted to be located in endosome membrane. Predicted to be active in cytoplasm and plasma membrane. Biomarker of hypertension. Orthologous to human RFFL (ring finger and FYVE like domain containing E3 ubiquitin protein ligase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 109.6), Kidney (RPKM 84.2) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rffl in Genome Data Viewer
    Location:
    10q26
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (68238273..68301225, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (67740711..67803669, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (70157621..70220618, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene chaperonin containing TCP1 subunit 6B Neighboring gene zinc finger protein 830 Neighboring gene uncharacterized LOC102547954 Neighboring gene DNA ligase 3 Neighboring gene RAD51 paralog D Neighboring gene U6 spliceosomal RNA Neighboring gene fibronectin type III domain containing 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    General gene information

    Markers

    Clone Names

    • MGC94279

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables p53 binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protease binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in biological_process ND
    No biological Data available
    more info
     
    acts_upstream_of_or_within intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cysteine-type endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of signal transduction by p53 class mediator IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of signal transduction by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of signal transduction by p53 class mediator ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of tumor necrosis factor-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of tumor necrosis factor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of tumor necrosis factor-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein K48-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K48-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of fibroblast migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of fibroblast migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    NOT located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in recycling endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase rififylin
    Names
    FYVE-RING finger protein Sakura
    RING finger and FYVE-like domain-containing protein 1
    RING finger protein SAKURA
    RING-type E3 ubiquitin transferase rififylin
    fring
    ring finger and FYVE like domain containing protein
    ring finger and FYVE-like domain containing 1
    NP_001004068.1
    NP_001386503.1
    XP_006247031.1
    XP_006247032.1
    XP_006247036.1
    XP_006247039.1
    XP_038941249.1
    XP_038941251.1
    XP_063124568.1
    XP_063124569.1
    XP_063124570.1
    XP_063124571.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004068.2NP_001004068.1  E3 ubiquitin-protein ligase rififylin isoform 2

      See identical proteins and their annotated locations for NP_001004068.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8L2QM30
      Related
      ENSRNOP00000067950.1, ENSRNOT00000076598.4
      Conserved Domains (2) summary
      cd15770
      Location:4492
      FYVE_CARP2; FYVE-like domain found in caspase regulator CARP2 and similar proteins
      pfam13920
      Location:283327
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    2. NM_001399574.1NP_001386503.1  E3 ubiquitin-protein ligase rififylin isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q6AY29, Q8CIN9
      UniProtKB/TrEMBL
      A0A8L2QM30, A6HHE4
      Related
      ENSRNOP00000045245.4, ENSRNOT00000041389.6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      68238273..68301225 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063268501.1XP_063124571.1  E3 ubiquitin-protein ligase rififylin isoform X7

      UniProtKB/TrEMBL
      A6HHE7
    2. XM_006246974.5XP_006247036.1  E3 ubiquitin-protein ligase rififylin isoform X5

      See identical proteins and their annotated locations for XP_006247036.1

      UniProtKB/TrEMBL
      A0A096MJC6, A0A8L2QM30
      Related
      ENSRNOP00000108638.1, ENSRNOT00000170731.1
      Conserved Domains (2) summary
      cd16500
      Location:315353
      RING-HC_CARP; RING finger, HC subclass, found in caspases-8 and -10-associated RING finger protein CARP-1, CARP-2 and similar proteins
      cl28890
      Location:4493
      FYVE_like_SF; FYVE domain like superfamily
    3. XM_063268500.1XP_063124570.1  E3 ubiquitin-protein ligase rififylin isoform X6

      UniProtKB/Swiss-Prot
      Q6AY29, Q8CIN9
      UniProtKB/TrEMBL
      A0A8L2QM30, A6HHE4
    4. XM_006246977.5XP_006247039.1  E3 ubiquitin-protein ligase rififylin isoform X5

      See identical proteins and their annotated locations for XP_006247039.1

      UniProtKB/TrEMBL
      A0A096MJC6, A0A8L2QM30
      Conserved Domains (2) summary
      cd16500
      Location:315353
      RING-HC_CARP; RING finger, HC subclass, found in caspases-8 and -10-associated RING finger protein CARP-1, CARP-2 and similar proteins
      cl28890
      Location:4493
      FYVE_like_SF; FYVE domain like superfamily
    5. XM_063268498.1XP_063124568.1  E3 ubiquitin-protein ligase rififylin isoform X3

      UniProtKB/TrEMBL
      A0A8L2QM30
    6. XM_006246969.4XP_006247031.1  E3 ubiquitin-protein ligase rififylin isoform X1

      See identical proteins and their annotated locations for XP_006247031.1

      UniProtKB/TrEMBL
      A0A8L2QM30
      Conserved Domains (3) summary
      pfam03873
      Location:193242
      RseA_C; Anti sigma-E protein RseA, C-terminal domain
      pfam13920
      Location:347391
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
      cl22851
      Location:79128
      PHD_SF; PHD finger superfamily
    7. XM_039085321.2XP_038941249.1  E3 ubiquitin-protein ligase rififylin isoform X5

      UniProtKB/TrEMBL
      A0A096MJC6, A0A8L2QM30
      Conserved Domains (2) summary
      cd16500
      Location:315353
      RING-HC_CARP; RING finger, HC subclass, found in caspases-8 and -10-associated RING finger protein CARP-1, CARP-2 and similar proteins
      cl28890
      Location:4493
      FYVE_like_SF; FYVE domain like superfamily
    8. XM_006246970.4XP_006247032.1  E3 ubiquitin-protein ligase rififylin isoform X2

      UniProtKB/TrEMBL
      A0A8L2QM30, A0A8L2QZU3
      Related
      ENSRNOP00000068131.2, ENSRNOT00000076596.4
      Conserved Domains (3) summary
      cd15770
      Location:79127
      FYVE_CARP2; FYVE-like domain found in caspase regulator CARP2 and similar proteins
      pfam03873
      Location:192241
      RseA_C; Anti sigma-E protein RseA, C-terminal domain
      pfam13920
      Location:346390
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    9. XM_063268499.1XP_063124569.1  E3 ubiquitin-protein ligase rififylin isoform X4

      UniProtKB/TrEMBL
      A0A8L2QM30
    10. XM_039085323.2XP_038941251.1  E3 ubiquitin-protein ligase rififylin isoform X5

      UniProtKB/TrEMBL
      A0A096MJC6, A0A8L2QM30
      Conserved Domains (2) summary
      cd16500
      Location:315353
      RING-HC_CARP; RING finger, HC subclass, found in caspases-8 and -10-associated RING finger protein CARP-1, CARP-2 and similar proteins
      cl28890
      Location:4493
      FYVE_like_SF; FYVE domain like superfamily