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    Elfn2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100910536, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Elfn2provided by RGD
    Official Full Name
    extracellular leucine-rich repeat and fibronectin type III domain containing 2provided by RGD
    Primary source
    RGD:1559693
    See related
    EnsemblRapid:ENSRNOG00000007934 AllianceGenome:RGD:1559693
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Elfn2-ps1; RGD1559693
    Summary
    Predicted to be involved in synaptic membrane adhesion. Predicted to act upstream of or within chemical synaptic transmission; establishment of protein localization; and gene expression. Predicted to be active in extracellular matrix; extracellular space; and postsynaptic density membrane. Orthologous to human ELFN2 (extracellular leucine rich repeat and fibronectin type III domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See Elfn2 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (112101998..112153280, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (110220293..110272770, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (119889786..119897038, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene cytohesin 4 Neighboring gene uncharacterized LOC134479754 Neighboring gene uncharacterized LOC102549375 Neighboring gene MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Neighboring gene caspase recruitment domain family, member 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Docking motif-guided mapping of the interactome of protein phosphatase-1. Hendrickx A, et al. Chem Biol, 2009 Apr 24. PMID 19389623
    2. Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Böhm D, et al. Oncol Rep, 2012 Aug. PMID 22664934, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within establishment of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synaptic membrane adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    extracellular leucine-rich repeat and fibronectin type III domain containing 2; protein phosphatase 1 regulatory subunit 29
    Names
    extracellular leucine-rich repeat and fibronectin type III containing 2
    extracellular leucine-rich repeat and fibronectin type III domain containing 2, pseudogene 1
    protein phosphatase 1 regulatory subunit 29-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432228.1 → NP_001419157.1  extracellular leucine-rich repeat and fibronectin type III domain containing 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6HSL8, D3ZH36

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      112101998..112153280 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242041.5 → XP_006242103.2  protein phosphatase 1 regulatory subunit 29

      UniProtKB/TrEMBL
      A6HSL8, D3ZH36
      Related
      ENSRNOP00000112651.1, ENSRNOT00000167735.1
      Conserved Domains (4) summary
      TIGR00864
      Location:157 → 227
      PCC; polycystin cation channel protein
      sd00031
      Location:60 → 80
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:200 → 226
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:80 → 139
      LRR_8; Leucine rich repeat

    2. XM_039080278.2 → XP_038936206.1  protein phosphatase 1 regulatory subunit 29

      Related
      ENSRNOP00000010609.3, ENSRNOT00000010609.6
      Conserved Domains (4) summary
      TIGR00864
      Location:157 → 227
      PCC; polycystin cation channel protein
      sd00031
      Location:60 → 80
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:200 → 226
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:80 → 139
      LRR_8; Leucine rich repeat

    3. XM_039080277.2 → XP_038936205.1  protein phosphatase 1 regulatory subunit 29

      UniProtKB/TrEMBL
      A6HSL8, D3ZH36
      Related
      ENSRNOP00000096572.1, ENSRNOT00000105973.2
      Conserved Domains (4) summary
      TIGR00864
      Location:157 → 227
      PCC; polycystin cation channel protein
      sd00031
      Location:60 → 80
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:200 → 226
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:80 → 139
      LRR_8; Leucine rich repeat

    4. XM_039080276.2 → XP_038936204.1  protein phosphatase 1 regulatory subunit 29

      UniProtKB/TrEMBL
      A6HSL8, D3ZH36
      Conserved Domains (4) summary
      TIGR00864
      Location:157 → 227
      PCC; polycystin cation channel protein
      sd00031
      Location:60 → 80
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:200 → 226
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:80 → 139
      LRR_8; Leucine rich repeat

    5. XM_063264450.1 → XP_063120520.1  protein phosphatase 1 regulatory subunit 29

      UniProtKB/TrEMBL
      A6HSL8, D3ZH36
      Related
      ENSRNOP00000103739.1, ENSRNOT00000146524.1
    Nucleotide Protein Strain
    Heading Accession and Version

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