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    Senp1 SUMO specific peptidase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300193, updated on 3-Dec-2024

    Summary

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    Symbol
    Senp1provided by RGD
    Full Name
    SUMO specific peptidase 1provided by RGD
    Primary source
    RGD:1310275
    See related
    EnsemblRapid:ENSRNOG00000022260 AllianceGenome:RGD:1310275
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable SUMO-specific endopeptidase activity and deSUMOylase activity. Involved in regulation of postsynapse assembly. Is active in glutamatergic synapse. Orthologous to human SENP1 (SUMO specific peptidase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 77.7), Spleen (RPKM 67.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Senp1 in Genome Data Viewer
    Location:
    7q36
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (131042237..131105826, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (129163173..129226766, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (139626444..139684587, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 106C Neighboring gene collagen type II alpha 1 chain Neighboring gene small nucleolar RNA SNORA17 Neighboring gene phosphofructokinase, muscle Neighboring gene uncharacterized LOC134479569 Neighboring gene transfer RNA threonine (anticodon AGU) 34

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Hypoxia protects H9c2 cells against Ferroptosis through SENP1-mediated protein DeSUMOylation. Bai YT, et al. Int J Med Sci, 2021. PMID 33746578, Free PMC Article
    2. Homeostatic synaptic scaling is regulated by protein SUMOylation. Craig TJ, et al. J Biol Chem, 2012 Jun 29. PMID 22582390, Free PMC Article
    3. [The expression and possible role of SENP1 in the pulmonary vascular wall of rat during the development of hypoxic pulmonary hypertension]. Tian H, et al. Zhongguo Ying Yong Sheng Li Xue Za Zhi, 2012 Mar. PMID 22737911
    4. SENP‑1 enhances hypoxia‑induced proliferation of rat pulmonary artery smooth muscle cells by regulating hypoxia‑inducible factor‑1α. Zhou F, et al. Mol Med Rep, 2016 Apr. PMID 26935971, Free PMC Article
    5. SENP1 has an important role in lung development and influences the differentiation of alveolar type 2 cells. Wan XQ, et al. Int J Mol Med, 2019 Jan. PMID 30387808, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Targeted transcriptional upregulation of SENP1 by CRISPR activation enhances deSUMOylation pathways to elicit antinociception in the spinal nerve ligation model of neuropathic pain.
      Title: Targeted transcriptional upregulation of SENP1 by CRISPR activation enhances deSUMOylation pathways to elicit antinociception in the spinal nerve ligation model of neuropathic pain.
    2. Hypoxia protects H9c2 cells against Ferroptosis through SENP1-mediated protein DeSUMOylation.
      Title: Hypoxia protects H9c2 cells against Ferroptosis through SENP1-mediated protein DeSUMOylation.
    3. SENP1 is an essential regulator of the balance between SUMOylation and deSUMOylation during lung development, specifically affecting the proliferation and differentiation status of AT2 cells.
      Title: SENP1 has an important role in lung development and influences the differentiation of alveolar type 2 cells.
    4. Lastly, the SENP1 knockdown HSC-T6 cells were successfully constructed, while the silence of SENP1 down-regulated the protein expression of alpha-SMA and SMAD2. In conclusion, this study provided a new regulation mechanism about the liver fibrosis process.
      Title: SENP1 attenuates the liver fibrosis through down-regulating the expression of SMAD2.
    5. SUMOspecific protease 1 was able to enhance the proliferative ability of pulmonary artery smooth muscle cells by initiating deSUMOylation of hypoxiainducible factor1alpha and increasing the expression of its downstream responsive gene, Vascular Endothelial Growth Factor.
      Title: SENP‑1 enhances hypoxia‑induced proliferation of rat pulmonary artery smooth muscle cells by regulating hypoxia‑inducible factor‑1α.
    6. analysis of the SENP-1 mediated SUMOylation-dependent regulatory pathway for GlyR endocytosis, which may have important physiological implications for proper neuronal excitability
      Title: Kainate receptor activation induces glycine receptor endocytosis through PKC deSUMOylation.
    7. SENP1 deficiency exacerbates ischemia-reperfusion injury in cardiomyocytes via a HIF1alpha-dependent pathway.
      Title: SENP1 protects against myocardial ischaemia/reperfusion injury via a HIF1α-dependent pathway.
    8. The dynamic expression of SENP1 protein may play a role in the development of hypoxic pulmonary hypertension.
      Title: [The expression and possible role of SENP1 in the pulmonary vascular wall of rat during the development of hypoxic pulmonary hypertension].
    9. Protein SUMOylation via senp1 plays an important and previously unsuspected role in synaptic trafficking of AMPARs that underlies homeostatic scaling.
      Title: Homeostatic synaptic scaling is regulated by protein SUMOylation.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SUMO-specific endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables deSUMOylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables deSUMOylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of potassium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein desumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein desumoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein desumoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of definitive erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mRNA stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of postsynapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynaptic cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sentrin-specific protease 1
    Names
    SUMO1/sentrin specific peptidase 1
    SUMO1/sentrin specific protease 1
    Sumo1/sentrin/SMT3 specific peptidase 1
    sentrin-specific protease 1-like
    XP_008764066.1
    XP_008764070.1
    XP_008764071.1
    XP_008764072.1
    XP_017450803.1
    XP_017450804.1
    XP_017450805.1
    XP_017450806.1
    XP_038936284.1
    XP_038936285.1
    XP_038936286.1
    XP_038936287.1
    XP_038936288.1
    XP_038936289.1
    XP_063120428.1
    XP_063120429.1
    XP_063120430.1
    XP_063120431.1
    XP_063120432.1
    XP_063120433.1
    XP_063120434.1
    XP_063120435.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432472.1 → NP_001419401.1  sentrin-specific protease 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      F1LVT6

    2. NM_001432473.1 → NP_001419402.1  sentrin-specific protease 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      F1LVT6

    3. NM_001432474.1 → NP_001419403.1  sentrin-specific protease 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      F1LVT6

    4. NM_001432476.1 → NP_001419405.1  sentrin-specific protease 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      F1LVT6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      131042237..131105826 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039080358.2 → XP_038936286.1  sentrin-specific protease 1 isoform X7

      UniProtKB/TrEMBL
      F1LVT6
      Conserved Domains (2) summary
      PRK04863
      Location:401 → 495
      mukB; chromosome partition protein MukB
      cl23802
      Location:468 → 690
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    2. XM_039080359.1 → XP_038936287.1  sentrin-specific protease 1 isoform X7

      UniProtKB/TrEMBL
      F1LVT6
      Conserved Domains (2) summary
      PRK04863
      Location:401 → 495
      mukB; chromosome partition protein MukB
      cl23802
      Location:468 → 690
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    3. XM_063264363.1 → XP_063120433.1  sentrin-specific protease 1 isoform X15

    4. XM_063264361.1 → XP_063120431.1  sentrin-specific protease 1 isoform X12

    5. XM_008765850.4 → XP_008764072.1  sentrin-specific protease 1 isoform X14

      UniProtKB/TrEMBL
      A0A0G2JVG1, F1LVT6
      Conserved Domains (1) summary
      cl23802
      Location:428 → 650
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    6. XM_008765848.3 → XP_008764070.1  sentrin-specific protease 1 isoform X9

      Related
      ENSRNOP00000107988.1, ENSRNOT00000150146.1
      Conserved Domains (1) summary
      cl23802
      Location:454 → 676
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    7. XM_063264359.1 → XP_063120429.1  sentrin-specific protease 1 isoform X8

      UniProtKB/TrEMBL
      F1LVT6

    8. XM_017595317.3 → XP_017450806.1  sentrin-specific protease 1 isoform X7

      UniProtKB/TrEMBL
      F1LVT6
      Conserved Domains (2) summary
      PRK04863
      Location:401 → 495
      mukB; chromosome partition protein MukB
      cl23802
      Location:468 → 690
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    9. XM_063264362.1 → XP_063120432.1  sentrin-specific protease 1 isoform X13

      UniProtKB/TrEMBL
      F1LVT6

    10. XM_063264360.1 → XP_063120430.1  sentrin-specific protease 1 isoform X10

      UniProtKB/TrEMBL
      F1LVT6

    11. XM_063264358.1 → XP_063120428.1  sentrin-specific protease 1 isoform X5

      UniProtKB/TrEMBL
      F1LVT6

    12. XM_017595314.3 → XP_017450803.1  sentrin-specific protease 1 isoform X2

      UniProtKB/TrEMBL
      F1LVT6

    13. XM_039080356.2 → XP_038936284.1  sentrin-specific protease 1 isoform X1

      UniProtKB/TrEMBL
      F1LVT6
      Conserved Domains (2) summary
      PRK04863
      Location:433 → 527
      mukB; chromosome partition protein MukB
      cl23802
      Location:500 → 722
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    14. XM_039080357.2 → XP_038936285.1  sentrin-specific protease 1 isoform X7

      UniProtKB/TrEMBL
      F1LVT6
      Conserved Domains (2) summary
      PRK04863
      Location:401 → 495
      mukB; chromosome partition protein MukB
      cl23802
      Location:468 → 690
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    15. XM_008765849.3 → XP_008764071.1  sentrin-specific protease 1 isoform X11

      Related
      ENSRNOP00000069472.3, ENSRNOT00000080056.3
      Conserved Domains (1) summary
      cl23802
      Location:448 → 670
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    16. XM_008765844.3 → XP_008764066.1  sentrin-specific protease 1 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K1R8, F1LVT6
      Related
      ENSRNOP00000071957.3, ENSRNOT00000089425.3
      Conserved Domains (1) summary
      cl23802
      Location:486 → 708
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    17. XM_017595315.3 → XP_017450804.1  sentrin-specific protease 1 isoform X3

      UniProtKB/TrEMBL
      F1LVT6

    18. XM_017595316.3 → XP_017450805.1  sentrin-specific protease 1 isoform X6

      UniProtKB/TrEMBL
      F1LVT6
      Related
      ENSRNOP00000031127.6, ENSRNOT00000030943.8

    19. XM_063264364.1 → XP_063120434.1  sentrin-specific protease 1 isoform X16

    20. XM_063264365.1 → XP_063120435.1  sentrin-specific protease 1 isoform X16

    21. XM_039080360.2 → XP_038936288.1  sentrin-specific protease 1 isoform X16

      Conserved Domains (2) summary
      COG5160
      Location:228 → 467
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
      PRK04863
      Location:176 → 270
      mukB; chromosome partition protein MukB

    22. XM_039080361.2 → XP_038936289.1  sentrin-specific protease 1 isoform X17

    RNA

    1. XR_005487405.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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