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    Prkg2 protein kinase cGMP-dependent 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25523, updated on 3-Dec-2024

    Summary

    Official Symbol
    Prkg2provided by RGD
    Official Full Name
    protein kinase cGMP-dependent 2provided by RGD
    Primary source
    RGD:3401
    See related
    EnsemblRapid:ENSRNOG00000002361 AllianceGenome:RGD:3401
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    cGKII; GDPKII
    Summary
    Enables cGMP-dependent protein kinase activity and identical protein binding activity. Involved in several processes, including negative regulation of chloride transport; peptidyl-serine autophosphorylation; and positive regulation of chondrocyte differentiation. Located in nuclear membrane. Biomarker of withdrawal disorder. Human ortholog(s) of this gene implicated in acromesomelic dysplasia-4 and spondylometaphyseal dysplasia. Orthologous to human PRKG2 (protein kinase cGMP-dependent 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 73.7), Brain (RPKM 40.7) and 4 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Prkg2 in Genome Data Viewer
    Location:
    14p22
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (10864020..10972617)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (10559882..10668479)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (12217121..12313616)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene RasGEF domain family, member 1B Neighboring gene uncharacterized LOC120096570 Neighboring gene PRELI domain containing 1, pseudogene 4 Neighboring gene uncharacterized LOC134481716 Neighboring gene bone morphogenetic protein 3 Neighboring gene cilia and flagella associated protein 299 Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cGMP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cGMP-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cGMP-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables mitogen-activated protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mitogen-activated protein kinase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein serine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cGMP-dependent protein kinase 2
    Names
    CGK 2
    cGK2
    cGMP dependent protein kinase type II
    cGMP-dependent protein kinase II
    protein kinase, cGMP- dependent, type 2
    protein kinase, cGMP-dependent, type II
    type II cGMP-dependent protein kinase
    NP_037144.1
    XP_038947566.1
    XP_063128946.1
    XP_063128947.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013012.2NP_037144.1  cGMP-dependent protein kinase 2

      See identical proteins and their annotated locations for NP_037144.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/Swiss-Prot
      Q64595
      Related
      ENSRNOP00000003237.2, ENSRNOT00000003237.6
      Conserved Domains (4) summary
      PTZ00263
      Location:417752
      PTZ00263; protein kinase A catalytic subunit; Provisional
      COG0664
      Location:162285
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:286401
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd05572
      Location:459718
      STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      10864020..10972617
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039091638.2XP_038947566.1  cGMP-dependent protein kinase 2 isoform X1

      Conserved Domains (2) summary
      cd00038
      Location:286401
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd05572
      Location:439689
      STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
    2. XM_063272876.1XP_063128946.1  cGMP-dependent protein kinase 2 isoform X2

      UniProtKB/TrEMBL
      A6K641
    3. XM_063272877.1XP_063128947.1  cGMP-dependent protein kinase 2 isoform X3