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    Clk1 CDC-like kinase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301434, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Clk1provided by RGD
    Official Full Name
    CDC-like kinase 1provided by RGD
    Primary source
    RGD:1311469
    See related
    EnsemblRapid:ENSRNOG00000025768 AllianceGenome:RGD:1311469
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein serine/threonine kinase activity and protein tyrosine kinase activity. Predicted to be involved in regulation of RNA splicing. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in nucleus. Orthologous to human CLK1 (CDC like kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 997.3), Spleen (RPKM 804.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Clk1 in Genome Data Viewer
    Location:
    9q31
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (67441962..67453180, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (59947774..59959002, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (65296777..65308017, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103690538 Neighboring gene aldehyde oxidase 2 Neighboring gene basic leucine zipper and W2 domains 1 Neighboring gene uncharacterized LOC134480578 Neighboring gene peptidylprolyl isomerase like 3 Neighboring gene NGG1 interacting factor 3 like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A new self-attenuated therapeutic influenza vaccine that uses host cell-restricted attenuation by artificial microRNAs. Wen K, et al. Int J Pharm, 2022 Jan 25. PMID 34883209, Free PMC Article
    2. Biochemical characterization and localization of the dual specificity kinase CLK1. Menegay HJ, et al. J Cell Sci, 2000 Sep. PMID 10954422
    3. STY, a tyrosine-phosphorylating enzyme with sequence homology to serine/threonine kinases. Howell BW, et al. Mol Cell Biol, 1991 Jan. PMID 1986248, Free PMC Article
    4. Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells. Eisenreich A, et al. Circ Res, 2009 Mar 13. PMID 19168442
    5. The CLK family kinases, CLK1 and CLK2, phosphorylate and activate the tyrosine phosphatase, PTP-1B. Moeslein FM, et al. J Biol Chem, 1999 Sep 17. PMID 10480872

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dual specificity protein kinase CLK1
    NP_001100383.2
    XP_063123017.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106913.2 → NP_001100383.2  dual specificity protein kinase CLK1

      See identical proteins and their annotated locations for NP_001100383.2

      Status: VALIDATED

      Source sequence(s)
      AA923848, BC081942, CV127206
      UniProtKB/TrEMBL
      A6IP60, D4ADG3
      Related
      ENSRNOP00000038335.4, ENSRNOT00000030934.8
      Conserved Domains (2) summary
      smart00220
      Location:160 → 476
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14213
      Location:147 → 476
      PKc_CLK1_4; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases 1 and 4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      67441962..67453180 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266947.1 → XP_063123017.1  dual specificity protein kinase CLK1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G1T6, A6IP62
    Nucleotide Protein Strain
    Heading Accession and Version

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