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    Rangap1 RAN GTPase activating protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362965, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rangap1provided by RGD
    Official Full Name
    RAN GTPase activating protein 1provided by RGD
    Primary source
    RGD:1310380
    See related
    EnsemblRapid:ENSRNOG00000031789 AllianceGenome:RGD:1310380
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables small GTPase binding activity and ubiquitin protein ligase binding activity. Involved in cellular response to vasopressin and response to axon injury. Located in several cellular components, including axon cytoplasm; cytoplasmic periphery of the nuclear pore complex; and mitotic spindle. Part of nuclear pore cytoplasmic filaments. Biomarker of sciatic neuropathy. Orthologous to human RANGAP1 (Ran GTPase activating protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 215.2), Brain (RPKM 146.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rangap1 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (115104820..115130564, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (113224695..113250441, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (122939266..122967178, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene L3MBTL histone methyl-lysine binding protein 2 Neighboring gene uncharacterized LOC120093698 Neighboring gene chondroadherin-like Neighboring gene zinc finger CCCH-type containing 7B Neighboring gene TEF transcription factor, PAR bZIP family member

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The Ran GTPase-activating protein (RanGAP1) is critically involved in smooth muscle cell differentiation, proliferation and migration following vascular injury: implications for neointima formation and restenosis. Vorpahl M, et al. PLoS One, 2014. PMID 24988324, Free PMC Article
    2. RAN GTPase is an effector of the invasive/metastatic phenotype induced by osteopontin. Kurisetty VV, et al. Oncogene, 2008 Dec 4. PMID 18794800
    3. Vasopressin V1a receptor is required for nucleocytoplasmic transport of mineralocorticoid receptor. Hori K, et al. Am J Physiol Renal Physiol, 2012 Oct. PMID 22811487
    4. A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex. Matunis MJ, et al. J Cell Biol, 1996 Dec. PMID 8978815, Free PMC Article
    5. Localized regulation of axonal RanGTPase controls retrograde injury signaling in peripheral nerve. Yudin D, et al. Neuron, 2008 Jul 31. PMID 18667152, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RanGAP1 expression, neointima formation in rat carotid arteries was associated with a significant upregulation of RanGAP1 expression at 3 and 7 days after balloon injury.
      Title: The Ran GTPase-activating protein (RanGAP1) is critically involved in smooth muscle cell differentiation, proliferation and migration following vascular injury: implications for neointima formation and restenosis.
    2. identifies RAN as a novel effector of osteopontin-mediated malignant transformation
      Title: RAN GTPase is an effector of the invasive/metastatic phenotype induced by osteopontin.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in activation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to peptide hormone stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to vasopressin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in negative regulation of protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear export IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear export ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein sumoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to axon injury IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SUMO ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in aggresome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in aggresome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axon cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic periphery of the nuclear pore complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear pore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear pore cytoplasmic filaments IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ran GTPase-activating protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001244855.1 → NP_001231784.1  ran GTPase-activating protein 1

      See identical proteins and their annotated locations for NP_001231784.1

      Status: VALIDATED

      Source sequence(s)
      BP492086, CA509531, CV126932, CX570737, DY317647, FQ217036
      UniProtKB/TrEMBL
      A0A8I6AMS6, A6HT14, F1MAA5
      Related
      ENSRNOP00000050029.6, ENSRNOT00000052098.7
      Conserved Domains (3) summary
      cd00116
      Location:21 → 358
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:51 → 81
      LRR_RI; leucine-rich repeat [structural motif]
      pfam07834
      Location:405 → 584
      RanGAP1_C; RanGAP1 C-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      115104820..115130564 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242101.5 → XP_006242163.1  ran GTPase-activating protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006242163.1

      UniProtKB/TrEMBL
      A0A8I6AMS6, A6HT14, F1MAA5
      Conserved Domains (3) summary
      cd00116
      Location:21 → 358
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:51 → 81
      LRR_RI; leucine-rich repeat [structural motif]
      pfam07834
      Location:405 → 584
      RanGAP1_C; RanGAP1 C-terminal domain

    2. XM_006242100.5 → XP_006242162.1  ran GTPase-activating protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K5R3, F1MAA5
      Related
      ENSRNOP00000073525.2, ENSRNOT00000090208.3
      Conserved Domains (3) summary
      cd00116
      Location:69 → 406
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:99 → 129
      LRR_RI; leucine-rich repeat [structural motif]
      pfam07834
      Location:453 → 632
      RanGAP1_C; RanGAP1 C-terminal domain

    3. XM_039079597.2 → XP_038935525.1  ran GTPase-activating protein 1 isoform X3

      Related
      ENSRNOP00000094275.2, ENSRNOT00000106829.2
      Conserved Domains (3) summary
      cd00116
      Location:69 → 406
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:99 → 129
      LRR_RI; leucine-rich repeat [structural motif]
      pfam07834
      Location:452 → 507
      RanGAP1_C; RanGAP1 C-terminal domain

    RNA

    1. XR_005486677.2 RNA Sequence

    2. XR_010053010.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001012199.1: Suppressed sequence

      Description
      NM_001012199.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version

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