Cadm4 cell adhesion molecule 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cadm4provided by RGD
Official Full Name: cell adhesion molecule 4provided by RGD
Primary source: RGD:1304722
See related: EnsemblRapid:ENSRNOG00000024243 AllianceGenome:RGD:1304722
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Upar; Igsf4c; Necl-4
Summary: Predicted to enable enzyme binding activity and vascular endothelial growth factor receptor binding activity. Involved in synaptic membrane adhesion. Is active in synaptic membrane. Orthologous to human CADM4 (cell adhesion molecule 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 489.5) and Spleen (RPKM 41.8) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (89203089..89225345)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (80075163..80097423)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (81365200..81369841)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Intracellular choline levels are significantly elevated in NECL4-deficient Schwann cells.
Title: Nectin-like 4 Complexes with Choline Transporter-like Protein-1 and Regulates Schwann Cell Choline Homeostasis and Lipid Biogenesis in Vitro.
These results demonstrate a key role for Necl, 2 and 4 in initiating peripheral nervous system myelination and implicate the Necl proteins as mediators of axo-glial interactions along the internode.
Title: Nectin-like proteins mediate axon Schwann cell interactions along the internode and are essential for myelination.
Necl4 protein is important for mediating axon-glia contact during myelination in peripheral nerves
Title: A central role for Necl4 (SynCAM4) in Schwann cell-axon interaction and myelination.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein phosphatase binding	IEA Inferred from Electronic Annotation more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables receptor tyrosine kinase binding	IEA Inferred from Electronic Annotation more info
enables receptor tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables vascular endothelial growth factor receptor 1 binding	IEA Inferred from Electronic Annotation more info
enables vascular endothelial growth factor receptor 1 binding	ISO Inferred from Sequence Orthology more info
enables vascular endothelial growth factor receptor 2 binding	IBA Inferred from Biological aspect of Ancestor more info
enables vascular endothelial growth factor receptor 2 binding	IEA Inferred from Electronic Annotation more info
enables vascular endothelial growth factor receptor 2 binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of peptidyl-threonine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of peptidyl-tyrosine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of vascular endothelial growth factor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular endothelial growth factor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of Rac protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of Rac protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of Rac protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of Rac protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell motility	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell motility	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell motility	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of wound healing	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of wound healing	IEA Inferred from Electronic Annotation more info
involved_in regulation of wound healing	ISO Inferred from Sequence Orthology more info
involved_in regulation of wound healing	ISS Inferred from Sequence or Structural Similarity more info
involved_in synaptic membrane adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic membrane adhesion	IEP Inferred from Expression Pattern more info	PubMed
involved_in synaptic membrane adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic membrane adhesion	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cell leading edge	IEA Inferred from Electronic Annotation more info
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
located_in cell leading edge	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cell-cell contact zone	IBA Inferred from Biological aspect of Ancestor more info
located_in cell-cell contact zone	IEA Inferred from Electronic Annotation more info
located_in cell-cell contact zone	ISO Inferred from Sequence Orthology more info
located_in cell-cell contact zone	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in synaptic membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cell adhesion molecule 4

Names: immunoglobulin superfamily, member 4C; nectin-like protein 4; urokinase plasminogen activator receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001047107.2 → NP_001040572.1 cell adhesion molecule 4 precursor

See identical proteins and their annotated locations for NP_001040572.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q1WIM1

UniProtKB/TrEMBL

A6J8Z3, F1M7V6

Related

ENSRNOP00000026793.6, ENSRNOT00000026793.8

Conserved Domains (5) summary

smart00294
Location:344 → 362

4.1m; putative band 4.1 homologues' binding motif

smart00408
Location:237 → 298

IGc2; Immunoglobulin C-2 Type

cd00096
Location:30 → 36

Ig; Ig strand A' [structural motif]

cd05885
Location:121 → 220

IgI_2_Necl-4; Second immunoglobulin (Ig)-like domain of nectin-like molecule-4 (Necl-4); member of the I-set of Ig superfamily domains

cl11960
Location:29 → 120

Ig; Immunoglobulin domain