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    Klf3 KLF transcription factor 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114845, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Klf3provided by RGD
    Official Full Name
    KLF transcription factor 3provided by RGD
    Primary source
    RGD:1593290
    See related
    EnsemblRapid:ENSRNOG00000002163 AllianceGenome:RGD:1593290
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Bklf; Tef-2
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cellular response to peptide. Predicted to be located in nucleoplasm. Orthologous to human KLF3 (KLF transcription factor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 161.3), Spleen (RPKM 105.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Klf3 in Genome Data Viewer
    Location:
    14p11
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (43828387..43859418, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (43474767..43505801, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (45142769..45173753, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene toll-like receptor 1 Neighboring gene toll-like receptor 10 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC103692863

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. KLF3 impacts insulin sensitivity and glucose uptake in skeletal muscle. Fu S, et al. Am J Physiol Cell Physiol, 2024 Nov 1. PMID 39250818
    2. Mouse Wee1 gene is repressed by Krüppel-like factor 3 (KLF3) via interaction with multiple upstream elements. Kitamura T, et al. Gene, 2012 Jan 25. PMID 22115574
    3. A network of Krüppel-like Factors (Klfs). Klf8 is repressed by Klf3 and activated by Klf1 in vivo. Eaton SA, et al. J Biol Chem, 2008 Oct 3. PMID 18687676, Free PMC Article
    4. Differential regulation of Krüppel-like factor family transcription factor expression in neonatal rat cardiac myocytes: effects of endothelin-1, oxidative stress and cytokines. Cullingford TE, et al. Biochim Biophys Acta, 2008 Jun. PMID 18406357, Free PMC Article
    5. Localization of 54 rat genes, and definition of new synteny groups conserved in the human and the rat. Szpirer C, et al. Mamm Genome, 2000 Sep. PMID 10967130

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. KLF3 impacts insulin sensitivity and glucose uptake in skeletal muscle.
      Title: KLF3 impacts insulin sensitivity and glucose uptake in skeletal muscle.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to peptide IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    Krueppel-like factor 3
    Names
    Basic Kruppel- like factor
    Kruppel like factor 3
    Kruppel-like factor 3 (basic)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105742.3 → NP_001099212.1  Krueppel-like factor 3

      See identical proteins and their annotated locations for NP_001099212.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A6JDG0, A6JDG1, D4A4V3
      Related
      ENSRNOP00000002960.4, ENSRNOT00000002960.8
      Conserved Domains (4) summary
      COG5048
      Location:169 → 331
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:261 → 283
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:259 → 283
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:305 → 330
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001433852.1 → NP_001420781.1  Krueppel-like factor 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A6JDG0, A6JDG1, D4A4V3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      43828387..43859418 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008770134.3 → XP_008768356.1  Krueppel-like factor 3 isoform X1

      Conserved Domains (4) summary
      COG5048
      Location:169 → 331
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:261 → 283
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:259 → 283
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:305 → 330
      zf-H2C2_2; Zinc-finger double domain

    2. XM_006250995.5 → XP_006251057.1  Krueppel-like factor 3 isoform X1

      See identical proteins and their annotated locations for XP_006251057.1

      UniProtKB/TrEMBL
      A6JDG0, A6JDG1, D4A4V3
      Conserved Domains (4) summary
      COG5048
      Location:169 → 331
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:261 → 283
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:259 → 283
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:305 → 330
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. XR_005492873.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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