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    Orc4 origin recognition complex, subunit 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295596, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Orc4provided by RGD
    Official Full Name
    origin recognition complex, subunit 4provided by RGD
    Primary source
    RGD:735212
    See related
    EnsemblRapid:ENSRNOG00000005021 AllianceGenome:RGD:735212
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA replication origin binding activity and nucleotide binding activity. Predicted to be involved in DNA replication initiation; polar body extrusion after meiotic divisions; and protein polymerization. Predicted to act upstream of or within DNA replication. Predicted to be located in chromosome, telomeric region; cytosol; and nuclear lumen. Predicted to be part of nuclear origin of replication recognition complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 2. Orthologous to human ORC4 (origin recognition complex subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 140.3), Adrenal (RPKM 134.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Orc4 in Genome Data Viewer
    Location:
    3q12
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (53700046..53743293, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (33290844..33334022, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (33034913..33075833, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486360 Neighboring gene uncharacterized LOC108350372 Neighboring gene uncharacterized LOC134486282 Neighboring gene activin A receptor type 2A Neighboring gene methyl-CpG binding domain protein 5 Neighboring gene uncharacterized LOC120101434 Neighboring gene enhancer of polycomb homolog 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Protein components of a rat brain synaptic junctional protein preparation. Langnaese K, et al. Brain Res Mol Brain Res, 1996 Nov. PMID 8915587
    2. Identification of HsORC4, a member of the human origin of replication recognition complex. Quintana DG, et al. J Biol Chem, 1997 Nov 7. PMID 9353276
    3. Identification and characterization of MmORC4 and MmORC5, two subunits of the mouse origin of replication recognition complex. Springer J, et al. Chromosoma, 1999 Aug. PMID 10460412
    4. ATP-dependent assembly of the human origin recognition complex. Siddiqui K, et al. J Biol Chem, 2007 Nov 2. PMID 17716973
    5. A WD-repeat protein stabilizes ORC binding to chromatin. Shen Z, et al. Mol Cell, 2010 Oct 8. PMID 20932478, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC72574

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA replication origin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA replication origin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA replication origin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA replication origin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA replication initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in polar body extrusion after meiotic divisions IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in polar body extrusion after meiotic divisions ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear origin of replication recognition complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear origin of replication recognition complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear origin of replication recognition complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear origin of replication recognition complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of origin recognition complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of origin recognition complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    origin recognition complex subunit 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429833.1 → NP_001416762.1  origin recognition complex subunit 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q6P9Z8
      UniProtKB/TrEMBL
      A0A8L2Q2Z8, A6JEZ2

    2. NM_199092.2 → NP_954523.1  origin recognition complex subunit 4

      See identical proteins and their annotated locations for NP_954523.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q6P9Z8
      UniProtKB/TrEMBL
      A0A8L2Q2Z8, A6JEZ2
      Related
      ENSRNOP00000085949.2, ENSRNOT00000099552.2
      Conserved Domains (2) summary
      COG1474
      Location:41 → 224
      CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
      pfam14629
      Location:226 → 413
      ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      53700046..53743293 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104470.2 → XP_038960398.1  origin recognition complex subunit 4 isoform X3

      UniProtKB/TrEMBL
      A0A8L2Q2Z8
      Conserved Domains (2) summary
      COG1474
      Location:41 → 238
      CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
      pfam14629
      Location:240 → 427
      ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus

    2. XM_063283239.1 → XP_063139309.1  origin recognition complex subunit 4 isoform X1

      UniProtKB/TrEMBL
      A0A8L2Q2Z8

    3. XM_039104469.2 → XP_038960397.1  origin recognition complex subunit 4 isoform X3

      UniProtKB/TrEMBL
      A0A8L2Q2Z8
      Related
      ENSRNOP00000006937.5, ENSRNOT00000006937.7
      Conserved Domains (2) summary
      COG1474
      Location:41 → 238
      CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
      pfam14629
      Location:240 → 427
      ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus

    4. XM_039104474.2 → XP_038960402.1  origin recognition complex subunit 4 isoform X6

      UniProtKB/TrEMBL
      A0A8L2Q2Z8
      Conserved Domains (2) summary
      COG1474
      Location:54 → 204
      CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
      pfam14629
      Location:209 → 368
      ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus

    5. XM_039104465.2 → XP_038960393.1  origin recognition complex subunit 4 isoform X1

      UniProtKB/TrEMBL
      A0A8L2Q2Z8
      Conserved Domains (2) summary
      COG1474
      Location:54 → 251
      CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
      pfam14629
      Location:253 → 440
      ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus

    6. XM_039104464.2 → XP_038960392.1  origin recognition complex subunit 4 isoform X1

      UniProtKB/TrEMBL
      A0A8L2Q2Z8
      Conserved Domains (2) summary
      COG1474
      Location:54 → 251
      CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
      pfam14629
      Location:253 → 440
      ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus

    7. XM_063283246.1 → XP_063139316.1  origin recognition complex subunit 4 isoform X5

    8. XM_039104471.2 → XP_038960399.1  origin recognition complex subunit 4 isoform X3

      UniProtKB/TrEMBL
      A0A8L2Q2Z8
      Conserved Domains (2) summary
      COG1474
      Location:41 → 238
      CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
      pfam14629
      Location:240 → 427
      ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus

    9. XM_063283244.1 → XP_063139314.1  origin recognition complex subunit 4 isoform X4

      UniProtKB/TrEMBL
      A0A8I5Y5K9, A0A8L2Q2Z8

    10. XM_063283240.1 → XP_063139310.1  origin recognition complex subunit 4 isoform X1

      UniProtKB/TrEMBL
      A0A8L2Q2Z8

    11. XM_063283243.1 → XP_063139313.1  origin recognition complex subunit 4 isoform X4

      UniProtKB/TrEMBL
      A0A8I5Y5K9, A0A8L2Q2Z8

    12. XM_039104463.2 → XP_038960391.1  origin recognition complex subunit 4 isoform X1

      UniProtKB/TrEMBL
      A0A8L2Q2Z8
      Conserved Domains (2) summary
      COG1474
      Location:54 → 251
      CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
      pfam14629
      Location:253 → 440
      ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus

    13. XM_039104461.2 → XP_038960389.1  origin recognition complex subunit 4 isoform X1

      UniProtKB/TrEMBL
      A0A8L2Q2Z8
      Conserved Domains (2) summary
      COG1474
      Location:54 → 251
      CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
      pfam14629
      Location:253 → 440
      ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus

    14. XM_008761705.4 → XP_008759927.1  origin recognition complex subunit 4 isoform X4

      See identical proteins and their annotated locations for XP_008759927.1

      UniProtKB/TrEMBL
      A0A8I5Y5K9, A0A8L2Q2Z8
      Conserved Domains (3) summary
      cd00009
      Location:57 → 224
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      smart00382
      Location:72 → 228
      AAA; ATPases associated with a variety of cellular activities
      pfam14629
      Location:239 → 416
      ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus

    15. XM_063283242.1 → XP_063139312.1  origin recognition complex subunit 4 isoform X4

      UniProtKB/TrEMBL
      A0A8I5Y5K9, A0A8L2Q2Z8
      Related
      ENSRNOP00000077265.1, ENSRNOT00000103065.2

    16. XM_039104460.2 → XP_038960388.1  origin recognition complex subunit 4 isoform X1

      UniProtKB/TrEMBL
      A0A8L2Q2Z8
      Conserved Domains (2) summary
      COG1474
      Location:54 → 251
      CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
      pfam14629
      Location:253 → 440
      ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus

    17. XM_039104472.2 → XP_038960400.1  origin recognition complex subunit 4 isoform X3

      UniProtKB/TrEMBL
      A0A8L2Q2Z8
      Conserved Domains (2) summary
      COG1474
      Location:41 → 238
      CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
      pfam14629
      Location:240 → 427
      ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus

    18. XM_039104473.2 → XP_038960401.1  origin recognition complex subunit 4 isoform X6

      UniProtKB/TrEMBL
      A0A8L2Q2Z8
      Conserved Domains (2) summary
      COG1474
      Location:54 → 204
      CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
      pfam14629
      Location:209 → 368
      ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus

    19. XM_039104466.2 → XP_038960394.1  origin recognition complex subunit 4 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A4W8, A0A8L2Q2Z8
      Conserved Domains (2) summary
      COG1474
      Location:48 → 245
      CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
      pfam14629
      Location:247 → 434
      ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P9Z8.1 GenPept UniProtKB/Swiss-Prot:Q6P9Z8

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