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    Cgnl1 cingulin-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315795, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cgnl1provided by RGD
    Official Full Name
    cingulin-like 1provided by RGD
    Primary source
    RGD:1304623
    See related
    EnsemblRapid:ENSRNOG00000054080 AllianceGenome:RGD:1304623
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1304623
    Summary
    Predicted to be involved in several processes, including negative regulation of small GTPase mediated signal transduction; negative regulation of stress fiber assembly; and protein localization to cell-cell junction. Predicted to be located in actin cytoskeleton and apical junction complex. Predicted to be part of protein-containing complex. Predicted to be active in bicellular tight junction. Orthologous to human CGNL1 (cingulin like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 795.7), Adrenal (RPKM 182.5) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cgnl1 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (81154169..81305598, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (72273401..72424842, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (78126670..78278490, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094203 Neighboring gene myocardial zonula adherens protein Neighboring gene dynein light chain LC8-type 1, pseudogene 1 Neighboring gene uncharacterized LOC134480205 Neighboring gene transcription factor 12 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. JACOP, a novel plaque protein localizing at the apical junctional complex with sequence similarity to cingulin. Ohnishi H, et al. J Biol Chem, 2004 Oct 29. PMID 15292197
    2. A role for ZO-1 and PLEKHA7 in recruiting paracingulin to tight and adherens junctions of epithelial cells. Pulimeno P, et al. J Biol Chem, 2011 May 13. PMID 21454477, Free PMC Article
    3. Cingulin is dispensable for epithelial barrier function and tight junction structure, and plays a role in the control of claudin-2 expression and response to duodenal mucosa injury. Guillemot L, et al. J Cell Sci, 2012 Nov 1. PMID 22946046
    4. Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex. Elbediwy A, et al. J Cell Biol, 2012 Aug 20. PMID 22891260, Free PMC Article
    5. ZO-1 controls endothelial adherens junctions, cell-cell tension, angiogenesis, and barrier formation. Tornavaca O, et al. J Cell Biol, 2015 Mar 16. PMID 25753039, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZO-1 and PLEKHA7 are paracingulin-interacting proteins that are involved in its recruitment to epithelial tight and adherens junctions, respectively
      Title: A role for ZO-1 and PLEKHA7 in recruiting paracingulin to tight and adherens junctions of epithelial cells.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in actin filament organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of small GTPase mediated signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in apical junction complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in bicellular tight junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cingulin-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108164.2 → NP_001101634.1  cingulin-like protein 1

      See identical proteins and their annotated locations for NP_001101634.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6AMD9, A6KEQ6, D4A3V5
      Related
      ENSRNOP00000106701.1, ENSRNOT00000131419.1
      Conserved Domains (1) summary
      pfam01576
      Location:617 → 1248
      Myosin_tail_1; Myosin tail

    2. NM_001389277.1 → NP_001376206.1  cingulin-like protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6AMD9, A6KEQ6, D4A3V5
      Related
      ENSRNOP00000103389.1, ENSRNOT00000165694.1
      Conserved Domains (1) summary
      pfam01576
      Location:617 → 1248
      Myosin_tail_1; Myosin tail

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      81154169..81305598 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008766286.4 → XP_008764508.1  cingulin-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_008764508.1

      UniProtKB/TrEMBL
      A0A8I6AMD9, A6KEQ6, D4A3V5
      Conserved Domains (1) summary
      pfam01576
      Location:617 → 1248
      Myosin_tail_1; Myosin tail

    2. XM_039081510.2 → XP_038937438.1  cingulin-like protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AMD9, A6KEQ6, D4A3V5
      Conserved Domains (1) summary
      pfam01576
      Location:617 → 1248
      Myosin_tail_1; Myosin tail

    3. XM_039081511.2 → XP_038937439.1  cingulin-like protein 1 isoform X2

      Conserved Domains (1) summary
      pfam01576
      Location:139 → 697
      Myosin_tail_1; Myosin tail
    Nucleotide Protein Strain
    Heading Accession and Version

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