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    Spag9 sperm associated antigen 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360600, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spag9provided by RGD
    Official Full Name
    sperm associated antigen 9provided by RGD
    Primary source
    RGD:1311289
    See related
    EnsemblRapid:ENSRNOG00000002749 AllianceGenome:RGD:1311289
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including JUN kinase binding activity; kinesin binding activity; and signaling adaptor activity. Involved in negative regulation of dendrite extension; negative regulation of neuron differentiation; and negative regulation of protein phosphorylation. Predicted to be located in centriolar satellite; cytosol; and lysosomal membrane. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and liver cirrhosis. Orthologous to human SPAG9 (sperm associated antigen 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 300.1), Muscle (RPKM 276.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Spag9 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (79440311..79574709)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (78943439..79077797)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (81693736..81827562)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene NME/NM23 nucleoside diphosphate kinase 1 Neighboring gene endogenous Bornavirus like nucleoprotein 1 Neighboring gene uncharacterized LOC120095280 Neighboring gene uncharacterized LOC102555690

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Serum levels of anti-sperm-associated antigen 9 antibody are elevated in patients with hepatocellular carcinoma. Ren B, et al. Oncol Lett, 2017 Dec. PMID 29344208, Free PMC Article
    2. Sperm-associated antigen 9 is a promising marker for early diagnosis of endometrial cancer. Baser E, et al. Asian Pac J Cancer Prev, 2013. PMID 24460345
    3. The scaffold protein c-Jun NH2-terminal kinase-associated leucine zipper protein regulates cell migration through interaction with the G protein G(alpha 13). Gantulga D, et al. J Biochem, 2008 Dec. PMID 18826971
    4. Structural and functional comparison of MIF ortholog from Plasmodium yoelii with MIF from its rodent host. Shao D, et al. Mol Immunol, 2010 Jan. PMID 20004020
    5. Regulation of neurite outgrowth by interactions between the scaffolding protein, JNK-associated leucine zipper protein, and neuronal growth-associated protein superior cervical ganglia clone 10. Xu H, et al. J Biol Chem, 2010 Feb 5. PMID 19959466, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results show that JLP (Spag9) negatively regulates NGF-induced neurite outgrowth by decreasing the level of phosphorylated SCG10.
      Title: Regulation of neurite outgrowth by interactions between the scaffolding protein, JNK-associated leucine zipper protein, and neuronal growth-associated protein superior cervical ganglia clone 10.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables JUN kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables JUN kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables MAP-kinase scaffold activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MAP-kinase scaffold activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinesin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinesin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor complex adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lysosome localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of dendrite extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within striated muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    C-Jun-amino-terminal kinase-interacting protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108290.2 → NP_001101760.2  C-Jun-amino-terminal kinase-interacting protein 4

      Status: VALIDATED

      Source sequence(s)
      CB605937, CB748350, FM062671, FM110716, JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I5Y1R0
      Related
      ENSRNOP00000077913.2, ENSRNOT00000117102.2
      Conserved Domains (3) summary
      pfam07926
      Location:56 → 162
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
      pfam09744
      Location:25 → 178
      Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
      pfam16471
      Location:392 → 447
      JIP_LZII; JNK-interacting protein leucine zipper II

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      79440311..79574709
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269405.1 → XP_063125475.1  C-Jun-amino-terminal kinase-interacting protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K6E8
      Related
      ENSRNOP00000073784.1, ENSRNOT00000085681.3

    2. XM_063269407.1 → XP_063125477.1  C-Jun-amino-terminal kinase-interacting protein 4 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K6E8

    3. XM_063269406.1 → XP_063125476.1  C-Jun-amino-terminal kinase-interacting protein 4 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K6E8, A0A8I5ZJK4
      Related
      ENSRNOP00000077739.1, ENSRNOT00000094632.2

    4. XM_006247146.4 → XP_006247208.1  C-Jun-amino-terminal kinase-interacting protein 4 isoform X5

      UniProtKB/TrEMBL
      A0A0G2K6E8, A0A8I6B3N0
      Related
      ENSRNOP00000096035.1, ENSRNOT00000106993.2
      Conserved Domains (3) summary
      pfam07926
      Location:56 → 162
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
      pfam09744
      Location:25 → 178
      Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
      pfam16471
      Location:406 → 461
      JIP_LZII; JNK-interacting protein leucine zipper II

    5. XM_063269408.1 → XP_063125478.1  C-Jun-amino-terminal kinase-interacting protein 4 isoform X4

      UniProtKB/TrEMBL
      A0A8I5Y1R0, E9PSJ4
      Related
      ENSRNOP00000003777.6, ENSRNOT00000003777.8

    6. XM_039086384.2 → XP_038942312.1  C-Jun-amino-terminal kinase-interacting protein 4 isoform X6

      UniProtKB/TrEMBL
      A0A8I5Y1R0
      Conserved Domains (5) summary
      COG0419
      Location:33 → 520
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      pfam17380
      Location:439 → 632
      DUF5401; Family of unknown function (DUF5401)
      pfam09744
      Location:24 → 178
      Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
      pfam16471
      Location:396 → 451
      JIP_LZII; JNK-interacting protein leucine zipper II
      pfam19056
      Location:942 → 1162
      WD40_2; WD40 repeated domain

    7. XM_006247147.4 → XP_006247209.1  C-Jun-amino-terminal kinase-interacting protein 4 isoform X7

      UniProtKB/TrEMBL
      A0A8I5Y1R0
      Conserved Domains (3) summary
      pfam07926
      Location:56 → 162
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
      pfam09744
      Location:25 → 178
      Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
      pfam16471
      Location:392 → 447
      JIP_LZII; JNK-interacting protein leucine zipper II

    8. XM_063269412.1 → XP_063125482.1  C-Jun-amino-terminal kinase-interacting protein 4 isoform X12

      UniProtKB/TrEMBL
      A0A8I6A5S1

    9. XM_006247151.5 → XP_006247213.1  C-Jun-amino-terminal kinase-interacting protein 4 isoform X11

      UniProtKB/TrEMBL
      A0A8I6B484
      Conserved Domains (1) summary
      pfam16471
      Location:249 → 304
      JIP_LZII; JNK-interacting protein leucine zipper II

    10. XM_006247154.5 → XP_006247216.1  C-Jun-amino-terminal kinase-interacting protein 4 isoform X14

      UniProtKB/TrEMBL
      A0A8I6B484
      Related
      ENSRNOP00000096462.1, ENSRNOT00000113361.2
      Conserved Domains (1) summary
      pfam16471
      Location:249 → 304
      JIP_LZII; JNK-interacting protein leucine zipper II

    11. XM_063269410.1 → XP_063125480.1  C-Jun-amino-terminal kinase-interacting protein 4 isoform X9

      UniProtKB/TrEMBL
      A0A8I6A5S1
      Related
      ENSRNOP00000086317.2, ENSRNOT00000095843.2

    12. XM_006247150.5 → XP_006247212.1  C-Jun-amino-terminal kinase-interacting protein 4 isoform X10

      UniProtKB/TrEMBL
      A0A8I6B484
      Conserved Domains (1) summary
      pfam16471
      Location:253 → 308
      JIP_LZII; JNK-interacting protein leucine zipper II

    13. XM_006247153.5 → XP_006247215.1  C-Jun-amino-terminal kinase-interacting protein 4 isoform X13

      UniProtKB/TrEMBL
      A0A8I6B484
      Conserved Domains (1) summary
      pfam16471
      Location:253 → 308
      JIP_LZII; JNK-interacting protein leucine zipper II

    14. XM_063269409.1 → XP_063125479.1  C-Jun-amino-terminal kinase-interacting protein 4 isoform X8

      UniProtKB/TrEMBL
      A0A8I6A5S1
    Nucleotide Protein Strain
    Heading Accession and Version

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