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    Mgst3 microsomal glutathione S-transferase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289197, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mgst3provided by RGD
    Official Full Name
    microsomal glutathione S-transferase 3provided by RGD
    Primary source
    RGD:1306373
    See related
    AllianceGenome:RGD:1306373
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables glutathione peroxidase activity. Predicted to be involved in leukotriene biosynthetic process and prostanoid metabolic process. Predicted to be located in mitochondrial outer membrane. Predicted to be active in endoplasmic reticulum and nuclear envelope. Orthologous to human MGST3 (microsomal glutathione S-transferase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 1263.8), Kidney (RPKM 1254.0) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mgst3 in Genome Data Viewer
    Location:
    13q24
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (82059480..82080418, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (79526541..79547479, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (85601499..85622392, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene transmembrane and coiled-coil domains 1 Neighboring gene aldehyde dehydrogenase 9 family, member A1 Neighboring gene NOP10 ribonucleoprotein like 2 Neighboring gene osteoclast stimulating factor 1, pseudogene 1 Neighboring gene uncharacterized LOC120096311

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Sodium nitroprusside regulates mRNA expressions of LTC4 synthesis enzymes in hepatic ischemia/reperfusion injury rats via NF-kappaB signaling pathway. Yang SL, et al. Pharmacology, 2007. PMID 17496435
    2. Molecular and catalytic properties of three rat leukotriene C(4) synthase homologs. Schröder O, et al. Biochem Biophys Res Commun, 2003 Dec 12. PMID 14637132
    3. The role of glutathione-S-transferase in anti-cancer drug resistance. Townsend DM, et al. Oncogene, 2003 Oct 20. PMID 14576844, Free PMC Article
    4. Identification and characterization of a novel microsomal enzyme with glutathione-dependent transferase and peroxidase activities. Jakobsson PJ, et al. J Biol Chem, 1997 Sep 5. PMID 9278457
    5. D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone. Popiolek M, et al. J Biol Chem, 2011 Aug 19. PMID 21700703, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables glutathione peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione peroxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione peroxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables glutathione transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glutathione transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables leukotriene-C4 synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in leukotriene biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in prostanoid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glutathione S-transferase 3, mitochondrial
    NP_001178523.1
    XP_006250271.1
    XP_038946430.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191594.2 → NP_001178523.1  glutathione S-transferase 3, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_001178523.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A8I6AAX9, A6IDL5, D4ADS4
      Conserved Domains (1) summary
      pfam01124
      Location:11 → 130
      MAPEG; MAPEG family

    2. NM_001434024.1 → NP_001420953.1  glutathione S-transferase 3, mitochondrial isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A8I6AAX9, A6IDL5, D4ADS4

    3. NM_001434025.1 → NP_001420954.1  glutathione S-transferase 3, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A8I6AAX9

    RNA

    1. NR_197623.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      82059480..82080418 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006250209.4 → XP_006250271.1  glutathione S-transferase 3, mitochondrial isoform X1

      Conserved Domains (1) summary
      pfam01124
      Location:11 → 130
      MAPEG; MAPEG family

    2. XM_039090502.2 → XP_038946430.1  glutathione S-transferase 3, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I6AAX9, A6IDL5, D4ADS4
      Conserved Domains (1) summary
      pfam01124
      Location:11 → 130
      MAPEG; MAPEG family
    Nucleotide Protein Strain
    Heading Accession and Version

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