Nip7 nucleolar pre-rRNA processing protein NIP7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nip7provided by RGD
Official Full Name: nucleolar pre-rRNA processing protein NIP7provided by RGD
Primary source: RGD:620069
See related: EnsemblRapid:ENSRNOG00000020391 AllianceGenome:RGD:620069
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nip7p; CGI-37; pEachy
Summary: Predicted to enable RNA binding activity. Predicted to be involved in ribosomal large subunit biogenesis. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of preribosome, large subunit precursor. Predicted to be active in nucleolus. Orthologous to human NIP7 (nucleolar pre-rRNA processing protein NIP7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 170.6), Spleen (RPKM 157.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (51872306..51874448)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (34962557..34964700)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (39257586..39259728)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ribosomal large subunit biogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosome assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of preribosome, large subunit precursor	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: 60S ribosome subunit biogenesis protein NIP7 homolog

Names: NIP7, nucleolar pre-rRNA processing protein; Saccharomyces cerevisiae Nip7p homolog; kDa93; nuclear import 7 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138847.2 → NP_620202.1 60S ribosome subunit biogenesis protein NIP7 homolog

See identical proteins and their annotated locations for NP_620202.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000019

UniProtKB/Swiss-Prot

Q5RJL7, Q9WV50

UniProtKB/TrEMBL

A6IYY9

Related

ENSRNOP00000104759.1, ENSRNOT00000163306.1

Conserved Domains (1) summary

COG1374
Location:1 → 176

NIP7; Rbosome biogenesis protein Nip4, contains PUA domain [Translation, ribosomal structure and biogenesis]