Ephx1 epoxide hydrolase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ephx1provided by RGD
Official Full Name: epoxide hydrolase 1provided by RGD
Primary source: RGD:2557
See related: EnsemblRapid:ENSRNOG00000003515 AllianceGenome:RGD:2557
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: mEH; MEH8
Summary: Enables cis-stilbene-oxide hydrolase activity and enzyme binding activity. Involved in several processes, including cellular response to glucocorticoid stimulus; diol biosynthetic process; and liver development. Located in intracellular membrane-bounded organelle and membrane. Biomarker of aflatoxins-related hepatocellular carcinoma. Human ortholog(s) of this gene implicated in several diseases, including Leber hereditary optic neuropathy; anemia (multiple); hematologic cancer (multiple); respiratory system disease (multiple); and toxic encephalopathy. Orthologous to human EPHX1 (epoxide hydrolase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 2589.7), Kidney (RPKM 779.3) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q26

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (95246079..95275852, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (92714315..92744105, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (99271390..99300580, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings show the critical role of soluble epoxide hydrolase S-nitrosation in cardiac ischemia-reperfusion injury.
Title: Soluble epoxide hydrolase activation by S-nitrosation contributes to cardiac ischemia-reperfusion injury.
involvement of PI3K signaling in regulation of ovarian xenobiotic metabolism by mEH.
Title: Ovarian expressed microsomal epoxide hydrolase: role in detoxification of 4-vinylcyclohexene diepoxide and regulation by phosphatidylinositol-3 kinase signaling.
The elevated expression of soluble epoxide hydrolase in kidney may play a role in high-salt induced hypertension.
Title: [Renal over expression of soluble epoxide hydrolase in rat with hypertension induced by high-salt].

Submit: New GeneRIF Correction

General gene information

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Markers

RH94562 (e-PCR)
- UniSTS:119810

Ephx1 (e-PCR), detects polymorphism
- UniSTS:186694

UniSTS:142997 (e-PCR)
- UniSTS:142997

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cis-stilbene-oxide hydrolase activity	IEA Inferred from Electronic Annotation more info
enables cis-stilbene-oxide hydrolase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cis-stilbene-oxide hydrolase activity	ISO Inferred from Sequence Orthology more info
enables cis-stilbene-oxide hydrolase activity	ISS Inferred from Sequence or Structural Similarity more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables epoxide hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables epoxide hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables epoxide hydrolase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables epoxide hydrolase activity	ISO Inferred from Sequence Orthology more info
enables oxysterol binding	IEA Inferred from Electronic Annotation more info
enables oxysterol binding	ISO Inferred from Sequence Orthology more info
enables oxysterol binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in arachidonate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in arachidonate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in arachidonate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in catabolic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to glucocorticoid stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in diol biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in epoxide metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in epoxide metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in epoxide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in hydrocarbon catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hydrocarbon catabolic process	ISO Inferred from Sequence Orthology more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in liver development	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to polycyclic arene	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to polycyclic arene	ISO Inferred from Sequence Orthology more info
involved_in response to toxic substance	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: epoxide hydrolase 1

Names: epoxide hydratase; epoxide hydrolase 1 (microsomal xenobiotic hydrolase); epoxide hydrolase 1, microsomal (xenobiotic); liver microsomal xenobiotic epoxide hydrolase; microsomal epoxide hydrolase

NP_001029262.1

EC 3.3.2.9

NP_036976.2

EC 3.3.2.9

XP_038946306.1

EC 3.3.2.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001034090.4 → NP_001029262.1 epoxide hydrolase 1

See identical proteins and their annotated locations for NP_001029262.1

Status: VALIDATED

Description

Transcript Variant: Variants 1 and 2 encode the same protein.

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

P07687

UniProtKB/TrEMBL

A0A8L2R8K5, A6JGI7

Conserved Domains (2) summary

pfam00561
Location:142 → 401

Abhydrolase_1; alpha/beta hydrolase fold

pfam06441
Location:48 → 157

EHN; Epoxide hydrolase N-terminus
NM_012844.4 → NP_036976.2 epoxide hydrolase 1

See identical proteins and their annotated locations for NP_036976.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate 5' terminal non-coding exon compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

P07687

UniProtKB/TrEMBL

A0A8L2R8K5, A6JGI7

Related

ENSRNOP00000004780.2, ENSRNOT00000004780.6

Conserved Domains (2) summary

pfam00561
Location:142 → 401

Abhydrolase_1; alpha/beta hydrolase fold

pfam06441
Location:48 → 157

EHN; Epoxide hydrolase N-terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

95246079..95275852 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039090378.2 → XP_038946306.1 epoxide hydrolase 1 isoform X1

UniProtKB/Swiss-Prot

P07687

UniProtKB/TrEMBL

A0A8L2R8K5, A6JGI7

Conserved Domains (2) summary

pfam00561
Location:142 → 401

Abhydrolase_1; alpha/beta hydrolase fold

pfam06441
Location:48 → 157

EHN; Epoxide hydrolase N-terminus