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    Fbxo17 F-box protein 17 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292757, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fbxo17provided by RGD
    Official Full Name
    F-box protein 17provided by RGD
    Primary source
    RGD:1308308
    See related
    EnsemblRapid:ENSRNOG00000019942 AllianceGenome:RGD:1308308
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fbg4; Fbx17; Fbxo26
    Summary
    Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in ERAD pathway; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; and glycoprotein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human FBXO17 (F-box protein 17). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 14.7), Testes (RPKM 10.9) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fbxo17 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (93129776..93151983)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (84002276..84024455)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (86903762..86919238)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene MARCKS-related protein-like Neighboring gene uncharacterized LOC108349512 Neighboring gene uncharacterized LOC134485106 Neighboring gene F-box protein 27 Neighboring gene mitochondrial ribosomal protein S12 Neighboring gene seryl-tRNA synthetase 2, mitochondrial Neighboring gene coiled-coil glutamate-rich protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases. Glenn KA, et al. J Biol Chem, 2008 May 9. PMID 18203720, Free PMC Article
    2. A family of mammalian F-box proteins. Winston JT, et al. Curr Biol, 1999 Oct 21. PMID 10531037
    3. Systematic analysis and nomenclature of mammalian F-box proteins. Jin J, et al. Genes Dev, 2004 Nov 1. PMID 15520277, Free PMC Article
    4. Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. Ebstein F, et al. Int J Biochem Cell Biol, 2009 May. PMID 19028597
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycoprotein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SCF ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    F-box only protein 17

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013064.2 → NP_001013082.2  F-box only protein 17

      Status: VALIDATED

      Source sequence(s)
      BC079218, BE120593
      UniProtKB/Swiss-Prot
      Q6AY27
      Conserved Domains (2) summary
      pfam04300
      Location:100 → 273
      FBA; F-box associated region
      pfam12937
      Location:27 → 59
      F-box-like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      93129776..93151983
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104122.2 → XP_038960050.1  F-box only protein 17 isoform X1

      Related
      ENSRNOP00000093850.2, ENSRNOT00000102551.2
      Conserved Domains (2) summary
      pfam04300
      Location:100 → 273
      FBA; F-box associated region
      pfam12937
      Location:27 → 59
      F-box-like

    2. XM_063283339.1 → XP_063139409.1  F-box only protein 17 isoform X3

    3. XM_063283346.1 → XP_063139416.1  F-box only protein 17 isoform X5

    4. XM_063283351.1 → XP_063139421.1  F-box only protein 17 isoform X6

    5. XM_063283366.1 → XP_063139436.1  F-box only protein 17 isoform X9

    6. XM_063283343.1 → XP_063139413.1  F-box only protein 17 isoform X4

    7. XM_063283356.1 → XP_063139426.1  F-box only protein 17 isoform X6

    8. XM_063283338.1 → XP_063139408.1  F-box only protein 17 isoform X2

      UniProtKB/Swiss-Prot
      Q6AY27
      Related
      ENSRNOP00000027006.6, ENSRNOT00000027006.9

    9. XM_039104125.2 → XP_038960053.1  F-box only protein 17 isoform X1

      Conserved Domains (2) summary
      pfam04300
      Location:100 → 273
      FBA; F-box associated region
      pfam12937
      Location:27 → 59
      F-box-like

    10. XM_063283332.1 → XP_063139402.1  F-box only protein 17 isoform X1

    11. XM_063283336.1 → XP_063139406.1  F-box only protein 17 isoform X1

    12. XM_039104146.1 → XP_038960074.1  F-box only protein 17 isoform X7

      UniProtKB/TrEMBL
      A6J9K3
      Conserved Domains (1) summary
      pfam04300
      Location:45 → 164
      FBA; F-box associated region

    13. XM_039104166.1 → XP_038960094.1  F-box only protein 17 isoform X7

      UniProtKB/TrEMBL
      A6J9K3
      Conserved Domains (1) summary
      pfam04300
      Location:45 → 164
      FBA; F-box associated region

    14. XM_039104187.1 → XP_038960115.1  F-box only protein 17 isoform X8

      UniProtKB/TrEMBL
      A0A8I6AKV1
      Conserved Domains (1) summary
      pfam04300
      Location:2 → 135
      FBA; F-box associated region

    RNA

    1. XR_010064589.1 RNA Sequence

    2. XR_010064590.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AY27.1 GenPept UniProtKB/Swiss-Prot:Q6AY27

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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