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    Gen1 GEN1 Holliday junction 5' flap endonuclease [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298884, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gen1provided by RGD
    Official Full Name
    GEN1 Holliday junction 5' flap endonucleaseprovided by RGD
    Primary source
    RGD:1559792
    See related
    EnsemblRapid:ENSRNOG00000004667 AllianceGenome:RGD:1559792
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1559792
    Summary
    Predicted to enable several functions, including DNA endonuclease activity; magnesium ion binding activity; and protein homodimerization activity. Predicted to be involved in DNA metabolic process and regulation of cell cycle process. Predicted to be located in centrosome. Orthologous to human GEN1 (GEN1 Holliday junction 5' flap endonuclease). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 59.2), Spleen (RPKM 50.9) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Gen1 in Genome Data Viewer
    Location:
    6q15
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (39666675..39697480, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (33947599..33978461, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (36910064..36940868, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel, modifier subfamily S, member 3 Neighboring gene mesogenin 1 Neighboring gene uncharacterized LOC102547959 Neighboring gene structural maintenance of chromosomes 6 Neighboring gene visinin-like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 5'-flap endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 5'-flap endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables crossover junction DNA endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables four-way junction DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables four-way junction DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    flap endonuclease GEN homolog 1
    Names
    Gen endonuclease homolog 1
    Gen homolog 1, endonuclease

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001434077.1NP_001421006.1  flap endonuclease GEN homolog 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      39666675..39697480 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039111944.2XP_038967872.1  flap endonuclease GEN homolog 1 isoform X2

      UniProtKB/TrEMBL
      A6HAP4, D3ZVS5
      Conserved Domains (3) summary
      cd09869
      Location:2206
      PIN_GEN1; FEN-like PIN domains of Gap Endonuclease 1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
      pfam18704
      Location:397457
      Chromo_2; Chromatin organization modifier domain 2
      cl22433
      Location:195337
      H3TH_StructSpec-5'-nucleases; H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination
    2. XM_006239896.4XP_006239958.1  flap endonuclease GEN homolog 1 isoform X1

      Conserved Domains (2) summary
      cd09869
      Location:1193
      PIN_GEN1; PIN domain of Gap Endonuclease 1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
      cl22433
      Location:195337
      H3TH_StructSpec-5'-nucleases; H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination
    3. XM_063261649.1XP_063117719.1  flap endonuclease GEN homolog 1 isoform X3

    4. XM_039111945.2XP_038967873.1  flap endonuclease GEN homolog 1 isoform X4

      Conserved Domains (3) summary
      cd09869
      Location:2206
      PIN_GEN1; FEN-like PIN domains of Gap Endonuclease 1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
      pfam18704
      Location:397420
      Chromo_2; Chromatin organization modifier domain 2
      cl22433
      Location:195337
      H3TH_StructSpec-5'-nucleases; H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination

    RNA

    1. XR_010052061.1 RNA Sequence

    2. XR_005505464.2 RNA Sequence

    3. XR_005505465.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106717.1: Suppressed sequence

      Description
      NM_001106717.1: This RefSeq was removed because currently there is insufficient support for the transcript.