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    C2cd2 C2 calcium-dependent domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304055, updated on 9-Dec-2024

    Summary

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    Official Symbol
    C2cd2provided by RGD
    Official Full Name
    C2 calcium-dependent domain containing 2provided by RGD
    Primary source
    RGD:735112
    See related
    EnsemblRapid:ENSRNOG00000001621 AllianceGenome:RGD:735112
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD735112
    Summary
    Predicted to be located in membrane. Orthologous to human C2CD2 (C2 calcium dependent domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 116.3), Liver (RPKM 109.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See C2cd2 in Genome Data Viewer
    Location:
    11q12
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (50694680..50759096, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (37225321..37289741, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (38354746..38420133, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene receptor-interacting serine-threonine kinase 4 Neighboring gene PR/SET domain 15 Neighboring gene uncharacterized LOC134480980 Neighboring gene ribosomal protein S17, pseudogene 5 Neighboring gene zinc finger and BTB domain containing 21

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. Hu YH, et al. BMC Genomics, 2006 Jun 16. PMID 16780588, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC72630

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    C2 domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199391.1 → NP_955423.1  C2 domain-containing protein 2

      See identical proteins and their annotated locations for NP_955423.1

      Status: PROVISIONAL

      Source sequence(s)
      BC062389
      UniProtKB/TrEMBL
      A0A8I5ZML0, A6IQH6, F7F9E0, Q6P691
      Related
      ENSRNOP00000002209.4, ENSRNOT00000002209.7
      Conserved Domains (2) summary
      pfam18696
      Location:71 → 223
      SMP_C2CD2L; Synaptotagmin-like, mitochondrial and lipid-binding domain
      cl14603
      Location:261 → 386
      C2; C2 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      50694680..50759096 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008768573.4 → XP_008766795.1  C2 domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZML0
      Conserved Domains (1) summary
      cl14603
      Location:259 → 384
      C2; C2 domain

    2. XM_008768572.4 → XP_008766794.1  C2 domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZML0
      Conserved Domains (1) summary
      cl14603
      Location:260 → 385
      C2; C2 domain

    3. XM_017598013.3 → XP_017453502.1  C2 domain-containing protein 2 isoform X5

      UniProtKB/TrEMBL
      A0A0G2JU40
      Related
      ENSRNOP00000105471.1, ENSRNOT00000150619.1

    4. XM_039088396.2 → XP_038944324.1  C2 domain-containing protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZML0
      Conserved Domains (2) summary
      pfam18696
      Location:71 → 190
      SMP_C2CD2L; Synaptotagmin-like, mitochondrial and lipid-binding domain
      cl14603
      Location:228 → 353
      C2; C2 domain

    5. XM_008768577.3 → XP_008766799.1  C2 domain-containing protein 2 isoform X7

      See identical proteins and their annotated locations for XP_008766799.1

      UniProtKB/TrEMBL
      A0A8I5ZML0
      Conserved Domains (1) summary
      cl14603
      Location:141 → 266
      C2; C2 domain

    6. XM_008768576.4 → XP_008766798.1  C2 domain-containing protein 2 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZML0
      Conserved Domains (1) summary
      cl14603
      Location:183 → 308
      C2; C2 domain

    7. XM_008768578.3 → XP_008766800.1  C2 domain-containing protein 2 isoform X7

      See identical proteins and their annotated locations for XP_008766800.1

      UniProtKB/TrEMBL
      A0A8I5ZML0
      Conserved Domains (1) summary
      cl14603
      Location:141 → 266
      C2; C2 domain

    8. XM_017598014.3 → XP_017453503.1  C2 domain-containing protein 2 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZML0
      Conserved Domains (1) summary
      cl14603
      Location:183 → 308
      C2; C2 domain

    9. XM_039088398.2 → XP_038944326.1  C2 domain-containing protein 2 isoform X8

      Conserved Domains (1) summary
      cl14603
      Location:89 → 214
      C2; C2 domain

    10. XM_039088395.2 → XP_038944323.1  C2 domain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JU40
      Related
      ENSRNOP00000106056.1, ENSRNOT00000128416.1
      Conserved Domains (2) summary
      pfam18696
      Location:71 → 223
      SMP_C2CD2L; Synaptotagmin-like, mitochondrial and lipid-binding domain
      cl14603
      Location:261 → 386
      C2; C2 domain

    RNA

    1. XR_010055959.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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