U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ston2 stonin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314349, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Ston2provided by RGD
    Official Full Name
    stonin 2provided by RGD
    Primary source
    RGD:1311502
    See related
    EnsemblRapid:ENSRNOG00000004458 AllianceGenome:RGD:1311502
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311502
    Summary
    Predicted to enable clathrin adaptor activity. Involved in synaptic vesicle endocytosis. Is active in presynapse. Orthologous to human STON2 (stonin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 63.1), Lung (RPKM 42.8) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Ston2 in Genome Data Viewer
    Location:
    6q31
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (116291898..116441391, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (110567485..110676376, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (115398586..115547552, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene thyroid stimulating hormone receptor Neighboring gene small nucleolar RNA SNORA79 Neighboring gene general transcription factor 2A subunit 1 Neighboring gene uncharacterized LOC134479244 Neighboring gene acid phosphatase 1, pseudogene 3 Neighboring gene uncharacterized LOC120103592 Neighboring gene SEL1L adaptor subunit of SYVN1 ubiquitin ligase Neighboring gene ferritin light chain 1, pseudogene 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Stonin 2 is a major adaptor protein for clathrin-mediated synaptic vesicle retrieval. Willox AK, et al. Curr Biol, 2012 Aug 7. PMID 22727701, Free PMC Article
    2. Stonin 2 is an AP-2-dependent endocytic sorting adaptor for synaptotagmin internalization and recycling. Diril MK, et al. Dev Cell, 2006 Feb. PMID 16459302
    3. Structure of the Eps15-stonin2 complex provides a molecular explanation for EH-domain ligand specificity. Rumpf J, et al. EMBO J, 2008 Feb 6. PMID 18200045, Free PMC Article
    4. Functional dissection of the interactions of stonin 2 with the adaptor complex AP-2 and synaptotagmin. Walther K, et al. Proc Natl Acad Sci U S A, 2004 Jan 27. PMID 14726597, Free PMC Article
    5. CSN complex controls the stability of selected synaptic proteins via a torsinA-dependent process. Granata A, et al. EMBO J, 2011 Jan 5. PMID 21102408, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. major adaptor for vesicle retrieval at hippocampal synapses
      Title: Stonin 2 is a major adaptor protein for clathrin-mediated synaptic vesicle retrieval.
    2. High-affinity ligand for the second EH domain (EH2) of the clathrin accessory protein Eps15.
      Title: Structure of the Eps15-stonin2 complex provides a molecular explanation for EH-domain ligand specificity.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables clathrin adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in clathrin-dependent endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synaptic vesicle endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle endocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synaptic vesicle endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synaptic vesicle endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of AP-2 adaptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in clathrin-coated vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    stonin-2
    Names
    homolog of stoned B

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135874.1 → NP_001129346.1  stonin-2

      See identical proteins and their annotated locations for NP_001129346.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      D4AB66
      UniProtKB/TrEMBL
      A6JEC9
      Related
      ENSRNOP00000005881.4, ENSRNOT00000005881.6
      Conserved Domains (2) summary
      cd09263
      Location:556 → 873
      AP_stonin-2_MHD; Mu homology domain (MHD) of adaptor-like protein (AP-like), stonin-2
      pfam12016
      Location:1 → 337
      Stonin2_N; Stonin 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      116291898..116441391 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063261953.1 → XP_063118023.1  stonin-2 isoform X1

      UniProtKB/Swiss-Prot
      D4AB66
      UniProtKB/TrEMBL
      A6JEC9

    2. XM_063261952.1 → XP_063118022.1  stonin-2 isoform X1

      UniProtKB/Swiss-Prot
      D4AB66
      UniProtKB/TrEMBL
      A6JEC9

    3. XM_063261954.1 → XP_063118024.1  stonin-2 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D4AB66.1 GenPept UniProtKB/Swiss-Prot:D4AB66

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous