U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Dnase1l1 deoxyribonuclease 1-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363522, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Dnase1l1provided by RGD
    Official Full Name
    deoxyribonuclease 1-like 1provided by RGD
    Primary source
    RGD:1359588
    See related
    EnsemblRapid:ENSRNOG00000055641 AllianceGenome:RGD:1359588
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA binding activity and deoxyribonuclease I activity. Predicted to be involved in DNA catabolic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in nucleus. Orthologous to human DNASE1L1 (deoxyribonuclease 1 like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 280.6), Lung (RPKM 126.8) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Dnase1l1 in Genome Data Viewer
    Location:
    Xq37
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (157208230..157216812, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (152056942..152065518, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (156429521..156438066)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene emerin Neighboring gene small nucleolar RNA SNORA70 Neighboring gene ribosomal protein L10 Neighboring gene small nuclear ribonucleoprotein polypeptide G, pseudogene 4 Neighboring gene tafazzin, phospholipid-lysophospholipid transacylase Neighboring gene ATPase H+ transporting accessory protein 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Physical and biochemical properties of mammalian DNase X proteins: non-AUG translation initiation of porcine and bovine mRNAs for DNase X. Shiokawa D, et al. Biochem J, 2005 Dec 15. PMID 16107205, Free PMC Article
    2. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables deoxyribonuclease I activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    deoxyribonuclease-1-like 1
    Names
    DNase I-like 1
    DNase X
    deoxyribonuclease I-like 1
    NP_001014245.2
    XP_006229664.1
    XP_038955853.1
    XP_038955854.1
    XP_038955855.1
    XP_038955856.1
    XP_038955857.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014223.3 → NP_001014245.2  deoxyribonuclease-1-like 1 precursor

      See identical proteins and their annotated locations for NP_001014245.2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/Swiss-Prot
      Q2QDE7
      UniProtKB/TrEMBL
      A6KRR9, Q6AYF0
      Related
      ENSRNOP00000073157.1, ENSRNOT00000083203.3
      Conserved Domains (1) summary
      cl00490
      Location:24 → 288
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      157208230..157216812 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006229602.4 → XP_006229664.1  deoxyribonuclease-1-like 1 isoform X1

      See identical proteins and their annotated locations for XP_006229664.1

      UniProtKB/TrEMBL
      A6KRS0, Q6AYF0
      Related
      ENSRNOP00000089112.2, ENSRNOT00000119460.2
      Conserved Domains (1) summary
      cl00490
      Location:24 → 262
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    2. XM_039099926.2 → XP_038955854.1  deoxyribonuclease-1-like 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A7H1, Q6AYF0
      Conserved Domains (1) summary
      cl00490
      Location:24 → 255
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    3. XM_039099925.2 → XP_038955853.1  deoxyribonuclease-1-like 1 isoform X2

      UniProtKB/TrEMBL
      Q6AYF0
      Conserved Domains (1) summary
      cl00490
      Location:24 → 276
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    4. XM_039099927.2 → XP_038955855.1  deoxyribonuclease-1-like 1 isoform X3

      Conserved Domains (1) summary
      cl00490
      Location:24 → 250
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    5. XM_039099929.2 → XP_038955857.1  deoxyribonuclease-1-like 1 isoform X5

      Conserved Domains (1) summary
      cl00490
      Location:23 → 191
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    6. XM_039099928.2 → XP_038955856.1  deoxyribonuclease-1-like 1 isoform X5

      Conserved Domains (1) summary
      cl00490
      Location:23 → 191
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2QDE7.1 GenPept UniProtKB/Swiss-Prot:Q2QDE7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous