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    Sgo2 shugoshin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316425, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sgo2provided by RGD
    Official Full Name
    shugoshin 2provided by RGD
    Primary source
    RGD:1308450
    See related
    EnsemblRapid:ENSRNOG00000027035 AllianceGenome:RGD:1308450
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sgol2
    Summary
    Predicted to be involved in meiotic sister chromatid cohesion. Predicted to act upstream of or within several processes, including meiotic nuclear division; meiotic sister chromatid cohesion; and positive regulation of maintenance of meiotic sister chromatid cohesion, centromeric. Predicted to be located in condensed chromosome, centromeric region and nuclear body. Predicted to be part of mitotic cohesin complex. Predicted to be active in kinetochore. Orthologous to human SGO2 (shugoshin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 218.1), Spleen (RPKM 116.7) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Sgo2 in Genome Data Viewer
    Location:
    9q31
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (67032083..67067439)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (59548605..59573229)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (64898380..64923023)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094689 Neighboring gene spermatogenesis associated, serine-rich 2-like Neighboring gene 60S ribosomal protein L30-like Neighboring gene potassium channel tetramerization domain containing 18 Neighboring gene U6 spliceosomal RNA Neighboring gene aldehyde oxidase 1 Neighboring gene uncharacterized LOC120094690 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene aldehyde oxidase 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in condensed chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    part_of mitotic cohesin complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    shugoshin 2
    Names
    shugoshin-like 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271191.3NP_001258120.1  shugoshin 2

      See identical proteins and their annotated locations for NP_001258120.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      D3ZWI4
      Related
      ENSRNOP00000105632.1, ENSRNOT00000164704.1
      Conserved Domains (2) summary
      pfam07558
      Location:5494
      Shugoshin_N; Shugoshin N-terminal coiled-coil region
      pfam07557
      Location:11411162
      Shugoshin_C; Shugoshin C terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      67032083..67067439
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267192.1XP_063123262.1  shugoshin 2 isoform X2

    2. XM_063267191.1XP_063123261.1  shugoshin 2 isoform X1