Fmo2 flavin containing dimethylaniline monoxygenase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fmo2provided by RGD
Official Full Name: flavin containing dimethylaniline monoxygenase 2provided by RGD
Primary source: RGD:628600
See related: EnsemblRapid:ENSRNOG00000003510 AllianceGenome:RGD:628600
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable N,N-dimethylaniline monooxygenase activity. Predicted to be involved in several processes, including NADPH oxidation; toxin metabolic process; and xenobiotic metabolic process. Predicted to act upstream of or within energy homeostasis; negative regulation of fatty acid oxidation; and oxygen metabolic process. Predicted to be located in membrane. Orthologous to human FMO2 (flavin containing dimethylaniline monoxygenase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 422.4), Kidney (RPKM 173.1) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q22

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (77755131..77777597, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (75221149..75244377, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (80752526..80775264, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FMO2 genetic polymorphism was associated with major differences in the S-oxidative metabolism.
Title: Identification and characterization of the FMO2 gene in Rattus norvegicus: a good model to study metabolic and toxicological consequences of the FMO2 polymorphism.

Submit: New GeneRIF Correction

General gene information

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Markers

RH132621 (e-PCR)
- UniSTS:215904

RH141445 (e-PCR)
- UniSTS:223439

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables N,N-dimethylaniline monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N,N-dimethylaniline monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables N,N-dimethylaniline monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables NADP binding	IEA Inferred from Electronic Annotation more info
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables hypotaurine monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in NADP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in NADPH oxidation	IEA Inferred from Electronic Annotation more info
involved_in NADPH oxidation	ISO Inferred from Sequence Orthology more info
involved_in NADPH oxidation	ISS Inferred from Sequence or Structural Similarity more info
involved_in energy homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within energy homeostasis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fatty acid oxidation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of fatty acid oxidation	ISO Inferred from Sequence Orthology more info
involved_in organic acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in organic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in oxygen metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within oxygen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in toxin metabolic process	IEA Inferred from Electronic Annotation more info
involved_in toxin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic metabolic process	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: dimethylaniline monooxygenase [N-oxide-forming] 2

Names: FMO 2; dimethylaniline oxidase 2; flavin containing monooxygenase 2; pulmonary flavin-containing monooxygenase 2

NP_653338.2

EC 1.14.13.8

XP_063128091.1

EC 1.14.13.8

XP_063128092.1

EC 1.14.13.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_144737.2 → NP_653338.2 dimethylaniline monooxygenase [N-oxide-forming] 2

See identical proteins and their annotated locations for NP_653338.2

Status: VALIDATED

Source sequence(s)

BC070904, CK365136

UniProtKB/Swiss-Prot

Q6IRI9

UniProtKB/TrEMBL

A6IDA6, G3V6F6

Related

ENSRNOP00000004762.3, ENSRNOT00000004762.7

Conserved Domains (3) summary

pfam00743
Location:3 → 532

FMO-like; Flavin-binding monooxygenase-like

pfam13450
Location:7 → 58

NAD_binding_8; NAD(P)-binding Rossmann-like domain

cl21454
Location:78 → 340

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

77755131..77777597 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063272021.1 → XP_063128091.1 dimethylaniline monooxygenase [N-oxide-forming] 2 isoform X1

UniProtKB/Swiss-Prot

Q6IRI9

UniProtKB/TrEMBL

A6IDA6, G3V6F6
XM_063272022.1 → XP_063128092.1 dimethylaniline monooxygenase [N-oxide-forming] 2 isoform X2