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    Greb1 growth regulating estrogen receptor binding 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500633, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Greb1provided by RGD
    Official Full Name
    growth regulating estrogen receptor binding 1provided by RGD
    Primary source
    RGD:1564091
    See related
    EnsemblRapid:ENSRNOG00000024651 AllianceGenome:RGD:1564091
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564091
    Summary
    Predicted to be involved in morphogenesis of an epithelium. Predicted to be located in membrane. Orthologous to human GREB1 (growth regulating estrogen receptor binding 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 121.4), Kidney (RPKM 58.3) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Greb1 in Genome Data Viewer
    Location:
    6q16
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (45169289..45321973, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (39440522..39562364, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (41932941..42002770, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene lipin 1 Neighboring gene neurotensin receptor 2 Neighboring gene E2F transcription factor 6 Neighboring gene Rho-associated coiled-coil containing protein kinase 2 Neighboring gene solute carrier family 66 member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry. Kang D, et al. J Proteome Res, 2008 Aug. PMID 18570454
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in morphogenesis of an epithelium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein GREB1
    Names
    growth regulation by estrogen in breast cancer 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427084.1 → NP_001414013.1  protein GREB1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      45169289..45321973 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262293.1 → XP_063118363.1  protein GREB1 isoform X1

      UniProtKB/TrEMBL
      F1LW89

    2. XM_063262292.1 → XP_063118362.1  protein GREB1 isoform X1

      UniProtKB/TrEMBL
      F1LW89

    3. XM_063262295.1 → XP_063118365.1  protein GREB1 isoform X1

      UniProtKB/TrEMBL
      F1LW89

    4. XM_063262299.1 → XP_063118369.1  protein GREB1 isoform X3

    5. XM_063262301.1 → XP_063118371.1  protein GREB1 isoform X5

    6. XM_063262300.1 → XP_063118370.1  protein GREB1 isoform X4

    7. XM_063262297.1 → XP_063118367.1  protein GREB1 isoform X2

    8. XM_063262291.1 → XP_063118361.1  protein GREB1 isoform X1

      UniProtKB/TrEMBL
      F1LW89

    9. XM_063262296.1 → XP_063118366.1  protein GREB1 isoform X1

      UniProtKB/TrEMBL
      F1LW89

    10. XM_063262294.1 → XP_063118364.1  protein GREB1 isoform X1

      UniProtKB/TrEMBL
      F1LW89

    11. XM_008764638.3 → XP_008762860.2  protein GREB1 isoform X1

      UniProtKB/TrEMBL
      F1LW89
      Related
      ENSRNOP00000036412.7, ENSRNOT00000032417.8
      Conserved Domains (1) summary
      pfam15782
      Location:1 → 1955
      GREB1; Gene regulated by oestrogen in breast cancer

    12. XM_039113142.1 → XP_038969070.1  protein GREB1 isoform X7

      UniProtKB/TrEMBL
      A6HAT2
      Conserved Domains (1) summary
      pfam15782
      Location:1 → 1042
      GREB1; Gene regulated by oestrogen in breast cancer

    13. XM_063262302.1 → XP_063118372.1  protein GREB1 isoform X6

    14. XM_063262303.1 → XP_063118373.1  protein GREB1 isoform X8

    15. XM_063262304.1 → XP_063118374.1  protein GREB1 isoform X9

    Nucleotide Protein Strain
    Heading Accession and Version

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