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    Mppe1 metallophosphoesterase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361344, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mppe1provided by RGD
    Official Full Name
    metallophosphoesterase 1provided by RGD
    Primary source
    RGD:1309184
    See related
    EnsemblRapid:ENSRNOG00000018648 AllianceGenome:RGD:1309184
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GPI anchor binding activity; GPI-mannose ethanolamine phosphate phosphodiesterase activity; and manganese ion binding activity. Predicted to be involved in GPI anchor biosynthetic process and endoplasmic reticulum to Golgi vesicle-mediated transport. Predicted to be located in several cellular components, including cis-Golgi network; endoplasmic reticulum exit site; and endoplasmic reticulum-Golgi intermediate compartment. Orthologous to human MPPE1 (metallophosphoesterase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 57.3), Heart (RPKM 51.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mppe1 in Genome Data Viewer
    Location:
    18q12.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (63033329..63051461, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (60763418..60781553, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (62946952..62966174, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene G protein subunit alpha L Neighboring gene uncharacterized LOC120098242 Neighboring gene charged multivesicular body protein 1B Neighboring gene uncharacterized LOC120098339 Neighboring gene inositol monophosphatase 2 Neighboring gene uncharacterized LOC134483046

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of a Golgi GPI-N-acetylgalactosamine transferase with tandem transmembrane regions in the catalytic domain. Hirata T, et al. Nat Commun, 2018 Jan 26. PMID 29374258, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GPI anchor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables GPI-mannose ethanolamine phosphate phosphodiesterase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables manganese ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GPI anchor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in GPI anchor biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cis-Golgi network ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum exit site ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    metallophosphoesterase 1
    Names
    post-GPI attachment to proteins factor 5
    NP_001101905.1
    XP_006254941.1
    XP_006254943.1
    XP_017456488.1
    XP_038952909.1
    XP_038952910.1
    XP_038952911.1
    XP_063133553.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108435.2 → NP_001101905.1  metallophosphoesterase 1

      See identical proteins and their annotated locations for NP_001101905.1

      Status: PROVISIONAL

      Source sequence(s)
      BC162043
      UniProtKB/Swiss-Prot
      B1WC86
      Related
      ENSRNOP00000025164.5, ENSRNOT00000025164.6
      Conserved Domains (2) summary
      cd08165
      Location:70 → 327
      MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain
      pfam00149
      Location:67 → 303
      Metallophos; Calcineurin-like phosphoesterase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      63033329..63051461 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096982.2 → XP_038952910.1  metallophosphoesterase 1 isoform X4

      Conserved Domains (1) summary
      cd08165
      Location:70 → 301
      MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain

    2. XM_039096981.2 → XP_038952909.1  metallophosphoesterase 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5Y647
      Conserved Domains (1) summary
      cd08165
      Location:70 → 302
      MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain

    3. XM_006254881.5 → XP_006254943.1  metallophosphoesterase 1 isoform X2

      Conserved Domains (2) summary
      cd08165
      Location:70 → 326
      MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain
      pfam00149
      Location:67 → 302
      Metallophos; Calcineurin-like phosphoesterase

    4. XM_017600999.3 → XP_017456488.1  metallophosphoesterase 1 isoform X5

    5. XM_063277483.1 → XP_063133553.1  metallophosphoesterase 1 isoform X2

    6. XM_006254879.5 → XP_006254941.1  metallophosphoesterase 1 isoform X1

      See identical proteins and their annotated locations for XP_006254941.1

      UniProtKB/Swiss-Prot
      B1WC86
      Conserved Domains (2) summary
      cd08165
      Location:70 → 327
      MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain
      pfam00149
      Location:67 → 303
      Metallophos; Calcineurin-like phosphoesterase

    7. XM_039096983.2 → XP_038952911.1  metallophosphoesterase 1 isoform X6

      Conserved Domains (1) summary
      cl13995
      Location:70 → 175
      MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B1WC86.1 GenPept UniProtKB/Swiss-Prot:B1WC86

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