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    Sphkap SPHK1 interactor, AKAP domain containing [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316561, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sphkapprovided by RGD
    Official Full Name
    SPHK1 interactor, AKAP domain containingprovided by RGD
    Primary source
    RGD:1311951
    See related
    EnsemblRapid:ENSRNOG00000016388 AllianceGenome:RGD:1311951
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Skip; RGD1311951
    Summary
    Predicted to enable protein kinase A binding activity. Predicted to be located in Z disc. Predicted to be active in mitochondrion. Orthologous to human SPHKAP (SPHK1 interactor, AKAP domain containing). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 225.5), Brain (RPKM 218.9) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sphkap in Genome Data Viewer
    Location:
    9q35
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (91957497..92105834, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (84509383..84657582, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (89050405..89195435, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene C-C motif chemokine ligand 20 Neighboring gene dynein assembly factor with WD repeats 1 Neighboring gene small ribosomal subunit protein uS4-like Neighboring gene uncharacterized LOC120094724

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Analysis of the cGMP/cAMP interactome using a chemical proteomics approach in mammalian heart tissue validates sphingosine kinase type 1-interacting protein as a genuine and highly abundant AKAP. Scholten A, et al. J Proteome Res, 2006 Jun. PMID 16739995
    2. Up-regulation of SKIP relates to retinal ganglion cells apoptosis after optic nerve crush in vivo. Wu Y, et al. J Mol Histol, 2014 Dec. PMID 25074585
    3. Sphingosine kinase interacting protein is an A-kinase anchoring protein specific for type I cAMP-dependent protein kinase. Kovanich D, et al. Chembiochem, 2010 May 3. PMID 20394097
    4. Regulation of insulin signaling in skeletal muscle by PIP3 phosphatase, SKIP, and endoplasmic reticulum molecular chaperone glucose-regulated protein 78. Ijuin T, et al. Biochim Biophys Acta, 2015 Dec. PMID 26376412
    5. An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria. Means CK, et al. Proc Natl Acad Sci U S A, 2011 Nov 29. PMID 22084075, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. findings underscore the specific and prominent role of SKIP and GRP78 in the regulation of insulin-dependent PI 3-kinase signaling in skeletal muscle
      Title: Regulation of insulin signaling in skeletal muscle by PIP3 phosphatase, SKIP, and endoplasmic reticulum molecular chaperone glucose-regulated protein 78.
    2. Up-regulation of SKIP in the retina is associated with retinal ganglion cells death after optic nerve crush.
      Title: Up-regulation of SKIP relates to retinal ganglion cells apoptosis after optic nerve crush in vivo.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein kinase A binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase A binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase A binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Z disc ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    A-kinase anchor protein SPHKAP
    Names
    SPHK1-interactor and AKAP domain-containing protein
    sphingosine kinase type 1-interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395141.1 → NP_001382070.1  A-kinase anchor protein SPHKAP isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A0G2K3J4
      Related
      ENSRNOP00000091046.2, ENSRNOT00000103600.2
      Conserved Domains (1) summary
      cl14906
      Location:1596 → 1695
      AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)

    2. NM_001395142.1 → NP_001382071.1  A-kinase anchor protein SPHKAP isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6JWC2, F1LNS0
      Related
      ENSRNOP00000076643.2, ENSRNOT00000113629.2
      Conserved Domains (1) summary
      cl14906
      Location:1625 → 1724
      AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      91957497..92105834 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267237.1 → XP_063123307.1  A-kinase anchor protein SPHKAP isoform X6

      UniProtKB/TrEMBL
      A0A0G2K3J4, A0A8I6AFF4

    2. XM_006245233.5 → XP_006245295.1  A-kinase anchor protein SPHKAP isoform X4

      UniProtKB/Swiss-Prot
      P0C6C0
      Related
      ENSRNOP00000101111.1, ENSRNOT00000132437.1
      Conserved Domains (1) summary
      cl14906
      Location:1599 → 1699
      AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)

    3. XM_017596483.3 → XP_017451972.1  A-kinase anchor protein SPHKAP isoform X2

      UniProtKB/TrEMBL
      F1LNS0

    4. XM_006245231.5 → XP_006245293.1  A-kinase anchor protein SPHKAP isoform X1

      UniProtKB/TrEMBL
      A0A0G2K3J4
      Related
      ENSRNOP00000100161.1, ENSRNOT00000134158.1
      Conserved Domains (1) summary
      cl14906
      Location:1620 → 1720
      AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)

    5. XM_063267234.1 → XP_063123304.1  A-kinase anchor protein SPHKAP isoform X3

      UniProtKB/Swiss-Prot
      P0C6C0

    6. XM_063267235.1 → XP_063123305.1  A-kinase anchor protein SPHKAP isoform X5

      UniProtKB/TrEMBL
      A0A0G2K3J4
      Related
      ENSRNOP00000072661.2, ENSRNOT00000090881.3

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001127492.1: Suppressed sequence

      Description
      NM_001127492.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0C6C0.1 GenPept UniProtKB/Swiss-Prot:P0C6C0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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