Ppme1 protein phosphatase methylesterase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ppme1provided by RGD
Official Full Name: protein phosphatase methylesterase 1provided by RGD
Primary source: RGD:1309683
See related: EnsemblRapid:ENSRNOG00000017227 AllianceGenome:RGD:1309683
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PME-1; RGD1309683
Summary: Enables protein kinase binding activity. Predicted to be involved in protein demethylation and protein phosphorylation. Orthologous to human PPME1 (protein phosphatase methylesterase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 214.6), Kidney (RPKM 97.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q32

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (164080242..164127261, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (154668099..154715079, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (165335242..165382216, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

findings provide new insight into how CA may improve glucose homeostasis through enhancing peripheral glucose clearance in tissues such as skeletal muscle through a PME-1/PP2A/PKB signalling axis
Title: Carnosic acid stimulates glucose uptake in skeletal muscle cells via a PME-1/PP2A/PKB signalling axis.

Submit: New GeneRIF Correction

General gene information

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Markers

D1Got149 (e-PCR)
- UniSTS:115804

AA943785 (e-PCR)
- UniSTS:260725

RH129650 (e-PCR)
- UniSTS:212947

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables lncRNA binding	ISO Inferred from Sequence Orthology more info
enables protein C-terminal methylesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein C-terminal methylesterase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase 2A binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase regulator activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in protein demethylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of sodium ion transport	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: protein phosphatase methylesterase 1

NP_001178767.1

EC 3.1.1.89

XP_063123246.1

EC 3.1.1.89

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191838.1 → NP_001178767.1 protein phosphatase methylesterase 1

See identical proteins and their annotated locations for NP_001178767.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q4FZT2

UniProtKB/TrEMBL

A6I6M6

Related

ENSRNOP00000023649.8, ENSRNOT00000023648.9

Conserved Domains (1) summary

COG0596
Location:66 → 370

MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]