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    Ift43 intraflagellar transport 43 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299209, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ift43provided by RGD
    Official Full Name
    intraflagellar transport 43provided by RGD
    Primary source
    RGD:1307392
    See related
    EnsemblRapid:ENSRNOG00000010194 AllianceGenome:RGD:1307392
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307392
    Summary
    Predicted to be involved in cilium assembly and intraciliary retrograde transport. Predicted to be located in centriolar satellite and centriole. Predicted to be part of intraciliary transport particle A. Predicted to be active in cilium. Human ortholog(s) of this gene implicated in cranioectodermal dysplasia 3; retinitis pigmentosa 81; and short-rib thoracic dysplasia 18 with polydactyly. Orthologous to human IFT43 (intraflagellar transport 43). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 181.4), Testes (RPKM 160.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ift43 in Genome Data Viewer
    Location:
    6q31
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (111460689..111537224)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (105729734..105806257)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (109939323..110016646)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene tubulin tyrosine ligase like 5 Neighboring gene uncharacterized LOC134479235 Neighboring gene transforming growth factor, beta 3 Neighboring gene uncharacterized LOC134479452 Neighboring gene G patch domain containing 2-like Neighboring gene estrogen-related receptor beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. C14ORF179 encoding IFT43 is mutated in Sensenbrenner syndrome. Arts HH, et al. J Med Genet, 2011 Jun. PMID 21378380
    2. Intraflagellar transport-A complex mediates ciliary entry and retrograde trafficking of ciliary G protein-coupled receptors. Hirano T, et al. Mol Biol Cell, 2017 Feb 1. PMID 27932497, Free PMC Article
    3. Regulation of cilium length and intraflagellar transport by the RCK-kinases ICK and MOK in renal epithelial cells. Broekhuis JR, et al. PLoS One, 2014. PMID 25243405, Free PMC Article
    4. TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia. Mukhopadhyay S, et al. Genes Dev, 2010 Oct 1. PMID 20889716, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intraciliary retrograde transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intraciliary retrograde transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of intraciliary transport particle A IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of intraciliary transport particle A ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    intraflagellar transport protein 43 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134525.2 → NP_001127997.1  intraflagellar transport protein 43 homolog isoform 2

      See identical proteins and their annotated locations for NP_001127997.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I5ZM33, A6JE54
      Related
      ENSRNOP00000078860.2, ENSRNOT00000109209.2
      Conserved Domains (1) summary
      pfam15305
      Location:55 → 178
      IFT43; Intraflagellar transport protein 43

    2. NM_001399448.1 → NP_001386377.1  intraflagellar transport protein 43 homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A6JE52, A6JE53, D3ZY35
      Related
      ENSRNOP00000013560.5, ENSRNOT00000013560.6
      Conserved Domains (1) summary
      pfam15305
      Location:62 → 191
      IFT43; Intraflagellar transport protein 43

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      111460689..111537224
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112051.2 → XP_038967979.1  intraflagellar transport protein 43 homolog isoform X4

    2. XM_039112052.2 → XP_038967980.1  intraflagellar transport protein 43 homolog isoform X5

    3. XM_039112053.2 → XP_038967981.1  intraflagellar transport protein 43 homolog isoform X6

    4. XM_017594099.3 → XP_017449588.1  intraflagellar transport protein 43 homolog isoform X1

    5. XM_017594100.3 → XP_017449589.1  intraflagellar transport protein 43 homolog isoform X3

      UniProtKB/TrEMBL
      A0A8I6G8V8, A6JE53, D3ZY35
      Related
      ENSRNOP00000082023.1, ENSRNOT00000112265.2

    6. XM_006240370.5 → XP_006240432.1  intraflagellar transport protein 43 homolog isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZRK4, A6JE53, D3ZY35
      Related
      ENSRNOP00000081023.1, ENSRNOT00000104110.2
      Conserved Domains (1) summary
      pfam15305
      Location:101 → 219
      IFT43; Intraflagellar transport protein 43

    7. XM_039112054.2 → XP_038967982.1  intraflagellar transport protein 43 homolog isoform X7

      Conserved Domains (1) summary
      pfam15305
      Location:2 → 112
      IFT43; Intraflagellar transport protein 43
    Nucleotide Protein Strain
    Heading Accession and Version

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