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    Fkbp14 FKBP prolyl isomerase 14 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362366, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fkbp14provided by RGD
    Official Full Name
    FKBP prolyl isomerase 14provided by RGD
    Primary source
    RGD:1311705
    See related
    EnsemblRapid:ENSRNOG00000009886 AllianceGenome:RGD:1311705
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable calcium ion binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome kyphoscoliotic type 2. Orthologous to human FKBP14 (FKBP prolyl isomerase 14). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 144.7), Lung (RPKM 101.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fkbp14 in Genome Data Viewer
    Location:
    4q24
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (85035840..85051917, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (83705531..83721515, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (84753628..84768314, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene WAS/WASL interacting protein family, member 3 Neighboring gene secernin 1 Neighboring gene uncharacterized LOC102553885 Neighboring gene pleckstrin homology domain containing A8 Neighboring gene translocase of outer mitochondrial membrane 7, pseudogene 3 Neighboring gene uncharacterized LOC134486771

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    peptidyl-prolyl cis-trans isomerase FKBP14
    Names
    FK506 binding protein 14
    NP_001013228.1
    XP_017448176.1
    XP_038963725.1
    XP_063142340.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013210.1 → NP_001013228.1  peptidyl-prolyl cis-trans isomerase FKBP14 precursor

      See identical proteins and their annotated locations for NP_001013228.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083746
      UniProtKB/TrEMBL
      A0A8I6A3P9, A6K0V4, Q5XID8
      Related
      ENSRNOP00000013205.6, ENSRNOT00000013205.9
      Conserved Domains (2) summary
      pfam00254
      Location:38 → 132
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam13499
      Location:141 → 204
      EF-hand_7; EF-hand domain pair

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      85035840..85051917 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107797.2 → XP_038963725.1  peptidyl-prolyl cis-trans isomerase FKBP14 isoform X2

      UniProtKB/TrEMBL
      F7ELR6
      Conserved Domains (2) summary
      COG0545
      Location:36 → 55
      FkpA; FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones]
      pfam13499
      Location:61 → 124
      EF-hand_7; EF-hand domain pair

    2. XM_017592687.3 → XP_017448176.1  peptidyl-prolyl cis-trans isomerase FKBP14 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZNP3
      Related
      ENSRNOP00000087077.2, ENSRNOT00000119659.2

    3. XM_063286270.1 → XP_063142340.1  peptidyl-prolyl cis-trans isomerase FKBP14 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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