Links from GEO Profiles

Showing Current items.

Tgfbr2 transforming growth factor, beta receptor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 81810, updated on 9-Dec-2024

Summary

Go to the top of the page Help

Official Symbol: Tgfbr2provided by RGD
Official Full Name: transforming growth factor, beta receptor 2provided by RGD
Primary source: RGD:69651
See related: EnsemblRapid:ENSRNOG00000013265 AllianceGenome:RGD:69651
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tgfbr2T; TGF-beta 2
Summary: Enables mitogen-activated protein kinase kinase kinase binding activity and transforming growth factor beta receptor activity, type II. Involved in several processes, including cellular response to acetaldehyde; negative regulation of cardiac muscle cell proliferation; and transforming growth factor beta receptor signaling pathway. Located in caveola and cell surface. Used to study membranoproliferative glomerulonephritis. Biomarker of artery disease (multiple); hepatobiliary system cancer (multiple); kidney disease; pulmonary fibrosis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including Loeys-Dietz syndrome 2; Lynch syndrome (multiple); Marfan syndrome; gastrointestinal system cancer (multiple); and mismatch repair cancer syndrome. Orthologous to human TGFBR2 (transforming growth factor beta receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 782.6), Adrenal (RPKM 511.9) and 8 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See Tgfbr2 in Genome Data Viewer

Location:: 8q32

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (124672677..124761741, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (115794537..115883615, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (124310288..124399345, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Epidermal Growth Factor Stimulates Transforming Growth Factor-Beta Receptor Type II Expression In Corneal Epithelial Cells.
Title: Epidermal Growth Factor Stimulates Transforming Growth Factor-Beta Receptor Type II Expression In Corneal Epithelial Cells.
Data suggest that the chloride channel-3 (CLC-3) might be modulated by transforming growth factor beta (TGF-beta) / TGF-beta Receptor II (TGF- beta RII) signaling pathway during the development of diabetic encephalopathy (DE).
Title: TGF-beta/TGF-beta RII/CLC-3 axis promotes cognitive disorders in diabetes.
Findings outlined in the current study demonstrated that 1,25(OH)2D3 was a promising therapeutic modality for treatment of Pulmonary arterial hypertension, function of which was exerted through miR-204 mediated Tgfbr2 signaling.
Title: 1,25(OH)(2)D(3) attenuates pulmonary arterial hypertension via microRNA-204 mediated Tgfbr2/Smad signaling.
The expressions of TGF-beta 1, TbetaRI, and TbetaRII in LPD and LPD + KA groups were significantly lower than those in NPD group and lower in LPD + KA group than those in LPD group
Title: Effects of Low-Protein Diets Supplemented with Ketoacid on Expression of TGF-β and Its Receptors in Diabetic Rats.
Blocking Hsp90-Cdc37 interactions during pressure overload hypertrophy results in ubiquitin-mediated proteasomal degradation of TGFBR2 leading to termination of TGF beta mediated signaling.
Title: Hsp90/Cdc37 assembly modulates TGFβ receptor-II to act as a profibrotic regulator of TGFβ signaling during cardiac hypertrophy.
The levels of collagen I and alpha-SMA were downregulated in CS/S58 gel-treated eyes. Conjunctival fibroblast proliferation and the inflammation response were also suppressed in the CS/S58 gel-treated group.
Title: Evaluation of Chitosan/Aptamer Targeting TGF-β Receptor II Thermo-Sensitive Gel for Scarring in Rat Glaucoma Filtration Surgery.
Morphological and biochemical data about the endosomal compartments involved in the internalization of TbetaRII upon inflammatory stimuli are shown.
Title: The subcellular compartmentalization of TGFβ-RII and the dynamics of endosomal formation during the signaling events: An in vivo study on rat mesothelial cells.
It is a one of fibrotic genes in kidney fibrosis.
Title: Melittin inhibits TGF-β-induced pro-fibrotic gene expression through the suppression of the TGFβRII-Smad, ERK1/2 and JNK-mediated signaling pathway.
Despite long-term obstruction injury, inhibition of TGF-betaRII and ALK5 core fucosylation ameliorated the progression of renal fibrosis, an effect independent of TGF-betaRII and ALK5 expression.
Title: Inhibition of TGF-β1-receptor posttranslational core fucosylation attenuates rat renal interstitial fibrosis.
We proved that miRNA-337 is associated with chondrogenesis through regulating TGFBR2 expression, and miRNA-337 can also influence cartilage-specific gene expression in chondrocytes.
Title: MicroRNA-337 is associated with chondrogenesis through regulating TGFBR2 expression.

Submit: New GeneRIF Correction See all GeneRIFs (31)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

Tgfbr2 (e-PCR), detects polymorphism
- UniSTS:265759

D8Got214 (e-PCR)
- UniSTS:115763

AI715297 (e-PCR)
- UniSTS:261712

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables BMP receptor activity	IEA Inferred from Electronic Annotation more info
enables SMAD binding	IEA Inferred from Electronic Annotation more info
enables SMAD binding	ISO Inferred from Sequence Orthology more info
enables activin binding	IBA Inferred from Biological aspect of Ancestor more info
enables activin receptor activity, type I	IBA Inferred from Biological aspect of Ancestor more info
enables activin receptor activity, type I	IEA Inferred from Electronic Annotation more info
enables activin receptor activity, type II	IEA Inferred from Electronic Annotation more info
enables glycosaminoglycan binding	IEA Inferred from Electronic Annotation more info
enables glycosaminoglycan binding	ISO Inferred from Sequence Orthology more info
enables kinase activator activity	IEA Inferred from Electronic Annotation more info
enables kinase activator activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables mitogen-activated protein kinase kinase kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	TAS Traceable Author Statement more info	PubMed
enables protein-containing complex binding	TAS Traceable Author Statement more info	PubMed
enables transforming growth factor beta binding	IBA Inferred from Biological aspect of Ancestor more info
enables transforming growth factor beta binding	IEA Inferred from Electronic Annotation more info
contributes_to transforming growth factor beta binding	ISO Inferred from Sequence Orthology more info
enables transforming growth factor beta binding	ISO Inferred from Sequence Orthology more info
enables transforming growth factor beta receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transforming growth factor beta receptor activity	ISO Inferred from Sequence Orthology more info
enables transforming growth factor beta receptor activity, type I	IEA Inferred from Electronic Annotation more info
enables transforming growth factor beta receptor activity, type II	IEA Inferred from Electronic Annotation more info
enables transforming growth factor beta receptor activity, type II	IMP Inferred from Mutant Phenotype more info	PubMed
enables transforming growth factor beta receptor activity, type II	ISO Inferred from Sequence Orthology more info
enables transforming growth factor beta receptor activity, type II	TAS Traceable Author Statement more info	PubMed
enables transforming growth factor beta receptor activity, type III	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables type I transforming growth factor beta receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables type I transforming growth factor beta receptor binding	IEA Inferred from Electronic Annotation more info
enables type I transforming growth factor beta receptor binding	ISO Inferred from Sequence Orthology more info
enables type III transforming growth factor beta receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Langerhans cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Langerhans cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in Notch signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in SMAD protein signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in activin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in activin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in animal organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in animal organ regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in aorta morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in aorta morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in aortic valve morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in aortic valve morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in artery morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in atrioventricular valve morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in brain development	IEA Inferred from Electronic Annotation more info
involved_in brain development	ISO Inferred from Sequence Orthology more info
involved_in branching involved in blood vessel morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within branching involved in blood vessel morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within bronchus development	ISO Inferred from Sequence Orthology more info
involved_in bronchus morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within bronchus morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cardiac left ventricle morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in cardiac left ventricle morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cartilage development	ISO Inferred from Sequence Orthology more info
NOT involved_in cell proliferation involved in endocardial cushion morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cellular response to acetaldehyde	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to growth factor stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in digestive tract development	IEP Inferred from Expression Pattern more info	PubMed
involved_in embryo implantation	IEP Inferred from Expression Pattern more info	PubMed
involved_in embryonic cranial skeleton morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in embryonic cranial skeleton morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic hemopoiesis	IEA Inferred from Electronic Annotation more info
involved_in embryonic hemopoiesis	ISO Inferred from Sequence Orthology more info
involved_in endocardial cushion fusion	IEA Inferred from Electronic Annotation more info
involved_in endocardial cushion fusion	ISO Inferred from Sequence Orthology more info
involved_in epithelial to mesenchymal transition	IEA Inferred from Electronic Annotation more info
involved_in epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in gastrulation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gastrulation	ISO Inferred from Sequence Orthology more info
involved_in growth plate cartilage chondrocyte growth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within growth plate cartilage chondrocyte growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within growth plate cartilage development	ISO Inferred from Sequence Orthology more info
involved_in heart development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
involved_in heart looping	IEA Inferred from Electronic Annotation more info
involved_in heart looping	ISO Inferred from Sequence Orthology more info
involved_in in utero embryonic development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in inferior endocardial cushion morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in inferior endocardial cushion morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in lens development in camera-type eye	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lens development in camera-type eye	ISO Inferred from Sequence Orthology more info
involved_in lens fiber cell apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lens fiber cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in lung development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within lung development	ISO Inferred from Sequence Orthology more info
involved_in lung lobe morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lung lobe morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in mammary gland morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mammary gland morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in membranous septum morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in membranous septum morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in miRNA transport	IEA Inferred from Electronic Annotation more info
involved_in miRNA transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cardiac muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in outflow tract morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in outflow tract septum morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in outflow tract septum morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of B cell tolerance induction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of B cell tolerance induction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of CD4-positive, alpha-beta T cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of CD4-positive, alpha-beta T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NK T cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of NK T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of SMAD protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell tolerance induction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of T cell tolerance induction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mesenchymal cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mesenchymal cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of reactive oxygen species metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of skeletal muscle tissue regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of tolerance induction to self antigen	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of tolerance induction to self antigen	ISO Inferred from Sequence Orthology more info
involved_in receptor-mediated endocytosis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of stem cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of stem cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of stem cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of stem cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in response to cholesterol	IEA Inferred from Electronic Annotation more info
involved_in response to cholesterol	ISO Inferred from Sequence Orthology more info
involved_in response to estrogen	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucose	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	TAS Traceable Author Statement more info	PubMed
involved_in response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to steroid hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in roof of mouth development	ISO Inferred from Sequence Orthology more info
involved_in secondary palate development	IEA Inferred from Electronic Annotation more info
involved_in secondary palate development	ISO Inferred from Sequence Orthology more info
involved_in smoothened signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
NOT involved_in superior endocardial cushion morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in trachea formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within trachea formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within trachea morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in transforming growth factor beta receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in transforming growth factor beta receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in tricuspid valve morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in tricuspid valve morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in vasculogenesis	IEA Inferred from Electronic Annotation more info
involved_in vasculogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in vasculogenesis	ISO Inferred from Sequence Orthology more info
involved_in ventricular septum morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of activin receptor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in caveola	IDA Inferred from Direct Assay more info	PubMed
located_in caveola	IEA Inferred from Electronic Annotation more info
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info
part_of transforming growth factor beta ligand-receptor complex	IEA Inferred from Electronic Annotation more info
part_of transforming growth factor beta ligand-receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: TGF-beta receptor type-2

Names: TGF-beta receptor type II; TGF-beta type II receptor; TGFR-2; tbetaR-II; transforming growth factor beta receptor type II; transforming growth factor, beta receptor II; transforming growth factor, beta receptor IIT; transforming growth factor-b type II receptor; transforming growth factor-beta type II receptor

NP_112394.4

EC 2.7.11.30

XP_008764912.1

EC 2.7.11.30

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031132.4 → NP_112394.4 TGF-beta receptor type-2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

P38438

UniProtKB/TrEMBL

D0VED2

Related

ENSRNOP00000093892.1, ENSRNOT00000116107.2

Conserved Domains (2) summary

cd14055
Location:248 → 542

STKc_TGFbR2_like; Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Type II Receptor

pfam08917
Location:49 → 152

ecTbetaR2; Transforming growth factor beta receptor 2 ectodomain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

124672677..124761741 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008766690.2 → XP_008764912.1 TGF-beta receptor type-2 isoform X1

UniProtKB/TrEMBL

A0A8L2QK15

Related

ENSRNOP00000035501.4, ENSRNOT00000037883.6

Conserved Domains (3) summary

smart00221
Location:269 → 566

STYKc; Protein kinase; unclassified specificity

cd14055
Location:273 → 567

STKc_TGFbR2_like; Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Type II Receptor

pfam08917
Location:74 → 177

ecTbetaR2; Transforming growth factor beta receptor 2 ectodomain