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    Tnnt1 troponin T1, slow skeletal type [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171409, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tnnt1provided by RGD
    Official Full Name
    troponin T1, slow skeletal typeprovided by RGD
    Primary source
    RGD:621852
    See related
    EnsemblRapid:ENSRNOG00000028041 AllianceGenome:RGD:621852
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    sTnT; tnTs; Fang2
    Summary
    Enables troponin T binding activity. Involved in slow-twitch skeletal muscle fiber contraction. Part of troponin complex. Human ortholog(s) of this gene implicated in nemaline myopathy 5A; nemaline myopathy 5B; and nemaline myopathy 5C. Orthologous to human TNNT1 (troponin T1, slow skeletal type). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 4333.7) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tnnt1 in Genome Data Viewer
    Location:
    1q12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (78349035..78359394)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (69306362..69316721)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (72889270..72899629)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene dynein, axonemal, assembly factor 3 Neighboring gene troponin I3, cardiac type Neighboring gene protein phosphatase 1, regulatory subunit 12C Neighboring gene EPS8-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression and functional properties of four slow skeletal troponin T isoforms in rat muscles. Kischel P, et al. Am J Physiol Cell Physiol, 2005 Aug. PMID 15788488
    2. Cellular fate of truncated slow skeletal muscle troponin T produced by Glu180 nonsense mutation in amish nemaline myopathy. Wang X, et al. J Biol Chem, 2005 Apr 8. PMID 15665378
    3. A novel nemaline myopathy in the Amish caused by a mutation in troponin T1. Johnston JJ, et al. Am J Hum Genet, 2000 Oct. PMID 10952871, Free PMC Article
    4. Alternative splicing generates variants in important functional domains of human slow skeletal troponin T. Gahlmann R, et al. J Biol Chem, 1987 Nov 25. PMID 2824479
    5. A troponin T mutation that causes infantile restrictive cardiomyopathy increases Ca2+ sensitivity of force development and impairs the inhibitory properties of troponin. Pinto JR, et al. J Biol Chem, 2008 Jan 25. PMID 18032382

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables tropomyosin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tropomyosin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables troponin T binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables troponin T binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of muscle contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of muscle contraction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sarcomere organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in skeletal muscle contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in slow-twitch skeletal muscle fiber contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in slow-twitch skeletal muscle fiber contraction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within transition between fast and slow fiber ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of troponin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of troponin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of troponin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of troponin complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    troponin T, slow skeletal muscle
    Names
    slow skeletal muscle troponin T
    troponin T type 1 (skeletal, slow)
    troponin T1, skeletal, slow

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277260.1 → NP_001264189.1  troponin T, slow skeletal muscle isoform 2

      See identical proteins and their annotated locations for NP_001264189.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AY334080, JAXUCZ010000001
      UniProtKB/TrEMBL
      A6KNL6
      Conserved Domains (1) summary
      pfam00992
      Location:67 → 203
      Troponin; Troponin

    2. NM_001277261.2 → NP_001264190.1  troponin T, slow skeletal muscle isoform 3

      See identical proteins and their annotated locations for NP_001264190.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an exon and uses an alternate splice site in the coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
      Source sequence(s)
      AY334082, JAXUCZ010000001
      UniProtKB/TrEMBL
      A6KNL6
      Conserved Domains (1) summary
      pfam00992
      Location:56 → 192
      Troponin; Troponin

    3. NM_001277262.2 → NP_001264191.1  troponin T, slow skeletal muscle isoform 4

      See identical proteins and their annotated locations for NP_001264191.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an exon in the coding region, compared to variant 1. The encoded isoform (4) is shorter, compared to isoform 1.
      Source sequence(s)
      AY334081, JAXUCZ010000001
      UniProtKB/TrEMBL
      A6KNL6
      Related
      ENSRNOP00000055633.4, ENSRNOT00000058843.7
      Conserved Domains (1) summary
      pfam00992
      Location:57 → 193
      Troponin

    4. NM_134388.2 → NP_599215.2  troponin T, slow skeletal muscle isoform 1

      See identical proteins and their annotated locations for NP_599215.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AY334079, JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q7TNA9, Q7TNB0, Q7TNB1, Q7TNB2, Q923S7
      UniProtKB/TrEMBL
      A6KNL6
      Related
      ENSRNOP00000038327.4, ENSRNOT00000034957.8
      Conserved Domains (1) summary
      pfam00992
      Location:68 → 204
      Troponin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      78349035..78359394
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276629.1 → XP_063132699.1  troponin T, slow skeletal muscle isoform X1

    2. XM_063276722.1 → XP_063132792.1  troponin T, slow skeletal muscle isoform X5

    3. XM_063276740.1 → XP_063132810.1  troponin T, slow skeletal muscle isoform X6

    4. XM_063276683.1 → XP_063132753.1  troponin T, slow skeletal muscle isoform X3

    5. XM_063276702.1 → XP_063132772.1  troponin T, slow skeletal muscle isoform X4

    6. XM_063276768.1 → XP_063132838.1  troponin T, slow skeletal muscle isoform X7

    7. XM_063276789.1 → XP_063132859.1  troponin T, slow skeletal muscle isoform X8

    8. XM_063276811.1 → XP_063132881.1  troponin T, slow skeletal muscle isoform X9

      UniProtKB/TrEMBL
      A6KNL7

    9. XM_063276664.1 → XP_063132734.1  troponin T, slow skeletal muscle isoform X2

    10. XM_063276839.1 → XP_063132909.1  troponin T, slow skeletal muscle isoform X10

      UniProtKB/TrEMBL
      A6KNL7
      Related
      ENSRNOP00000076828.2, ENSRNOT00000101852.2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TNB2.3 GenPept UniProtKB/Swiss-Prot:Q7TNB2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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