Tgm1 transglutaminase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tgm1provided by RGD
Official Full Name: transglutaminase 1provided by RGD
Primary source: RGD:61838
See related: EnsemblRapid:ENSRNOG00000020136 AllianceGenome:RGD:61838
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable identical protein binding activity and protein-glutamine gamma-glutamyltransferase activity. Predicted to be involved in several processes, including keratinocyte differentiation; peptide cross-linking; and positive regulation of keratinocyte proliferation. Predicted to act upstream of or within animal organ morphogenesis. Predicted to be located in adherens junction and membrane. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 1. Orthologous to human TGM1 (transglutaminase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 44.1), Lung (RPKM 20.1) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p13

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (33160985..33175632, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (29191039..29206000, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (34378136..34393150, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression, activity, and functionality of TG1 and TG2 are decreased in the aorta, but not in the vena cava, from hypertensive rats.
Title: Transglutaminase activity is decreased in large arteries from hypertensive rats compared with normotensive controls.
Forced expression of TG1 or TG2 proteins is sufficient to induce neuronal death in Rattus norvegicus cortical neurons in vitro.
Title: Transglutaminase inhibition protects against oxidative stress-induced neuronal death downstream of pathological ERK activation.
Transglutaminase inhibition reduces fibrosis and preserves function in experimental chronic kidney disease
Title: Transglutaminase inhibition reduces fibrosis and preserves function in experimental chronic kidney disease.
These molecular and cellular data strongly suggest that TG(R) promotes axonal elongation at the surface of injured RGCs after optic nerve injury.
Title: Upregulation of retinal transglutaminase during the axonal elongation stage of goldfish optic nerve regeneration.
Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase
Title: Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein-glutamine gamma-glutamyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-glutamine gamma-glutamyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-glutamine gamma-glutamyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-glutamine gamma-glutamyltransferase activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within animal organ morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in keratinization	IEA Inferred from Electronic Annotation more info
involved_in keratinocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in keratinocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in peptide cross-linking	ISO Inferred from Sequence Orthology more info
involved_in peptide cross-linking	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of cell cycle	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of keratinocyte proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of keratinocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of keratinocyte proliferation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: protein-glutamine gamma-glutamyltransferase K

Names: TG(K); TGK; TGase K; TGase-1; epidermal TGase; glutamine gamma-glutamyltransferase K; transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase); transglutaminase 1, K polypeptide; transglutaminase K

NP_113847.1

EC 2.3.2.13

XP_006252076.1

EC 2.3.2.13

XP_008768913.1

EC 2.3.2.13

XP_038949552.1

EC 2.3.2.13

XP_063130669.1

EC 2.3.2.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001431338.1 → NP_001418267.1 protein-glutamine gamma-glutamyltransferase K isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000015

UniProtKB/Swiss-Prot

P23606, Q4QRA6

UniProtKB/TrEMBL

A0A8I5ZX14, A6KH40
NM_001431339.1 → NP_001418268.1 protein-glutamine gamma-glutamyltransferase K isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000015

UniProtKB/Swiss-Prot

P23606, Q4QRA6

UniProtKB/TrEMBL

A0A8I5ZX14, A6KH40
NM_001431340.1 → NP_001418269.1 protein-glutamine gamma-glutamyltransferase K isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000015

UniProtKB/TrEMBL

A0A8I5ZX14
NM_001431341.1 → NP_001418270.1 protein-glutamine gamma-glutamyltransferase K isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000015

UniProtKB/TrEMBL

A0A8I5ZX14
NM_031659.2 → NP_113847.1 protein-glutamine gamma-glutamyltransferase K isoform 1

See identical proteins and their annotated locations for NP_113847.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000015

UniProtKB/Swiss-Prot

P23606, Q4QRA6

UniProtKB/TrEMBL

A0A8I5ZX14, A6KH40

Related

ENSRNOP00000084357.1, ENSRNOT00000119383.2

Conserved Domains (3) summary

smart00460
Location:379 → 470

TGc; Transglutaminase/protease-like homologues

pfam00868
Location:119 → 234

Transglut_N; Transglutaminase family

pfam00927
Location:699 → 796

Transglut_C; Transglutaminase family, C-terminal ig like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

33160985..33175632 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039093624.2 → XP_038949552.1 protein-glutamine gamma-glutamyltransferase K isoform X2

Conserved Domains (3) summary

smart00460
Location:343 → 434

TGc; Transglutaminase/protease-like homologues

pfam00868
Location:118 → 234

Transglut_N; Transglutaminase family

pfam00927
Location:663 → 760

Transglut_C; Transglutaminase family, C-terminal ig like domain
XM_006252014.5 → XP_006252076.1 protein-glutamine gamma-glutamyltransferase K isoform X1

Related

ENSRNOP00000027315.2, ENSRNOT00000027315.7

Conserved Domains (3) summary

smart00460
Location:379 → 470

TGc; Transglutaminase/protease-like homologues

pfam00868
Location:119 → 234

Transglut_N; Transglutaminase family

pfam00927
Location:699 → 796

Transglut_C; Transglutaminase family, C-terminal ig like domain
XM_008770691.4 → XP_008768913.1 protein-glutamine gamma-glutamyltransferase K isoform X1

Conserved Domains (3) summary

smart00460
Location:379 → 470

TGc; Transglutaminase/protease-like homologues

pfam00868
Location:119 → 234

Transglut_N; Transglutaminase family

pfam00927
Location:699 → 796

Transglut_C; Transglutaminase family, C-terminal ig like domain
XM_063274599.1 → XP_063130669.1 protein-glutamine gamma-glutamyltransferase K isoform X2