Ptpmt1 protein tyrosine phosphatase, mitochondrial 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ptpmt1provided by RGD
Official Full Name: protein tyrosine phosphatase, mitochondrial 1provided by RGD
Primary source: RGD:1589783
See related: EnsemblRapid:ENSRNOG00000009723 AllianceGenome:RGD:1589783
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Plip
Summary: Predicted to enable phosphatidylglycerophosphatase activity and phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus. Located in mitochondrial inner membrane. Orthologous to human PTPMT1 (protein tyrosine phosphatase mitochondrial 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 137.8), Brain (RPKM 136.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q24

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (97345752..97355396, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (76889922..76899427, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (79734961..79743737, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PTPMT1 protects cardiomyocytes from necroptosis induced by gamma-ray irradiation through alleviating mitochondria injury.
Title: PTPMT1 protects cardiomyocytes from necroptosis induced by γ-ray irradiation through alleviating mitochondria injury.

Submit: New GeneRIF Correction

General gene information

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Markers

BG378525 (e-PCR)
- UniSTS:245088

RH144148 (e-PCR)
- UniSTS:233394

AA963126 (e-PCR)
- UniSTS:250572

UniSTS:495313 (e-PCR)
- UniSTS:495313

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables MAP kinase serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables calmodulin-dependent protein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS140 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylglycerophosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylglycerophosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylglycerophosphatase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylglycerophosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	ISO Inferred from Sequence Orthology more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cardiolipin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cardiolipin biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of intrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

Names: PTEN-like phosphatase

NP_001099196.1

EC 3.1.3.16

EC 3.1.3.27

EC 3.1.3.48

XP_038960364.1

EC 3.1.3.16

EC 3.1.3.27

EC 3.1.3.48

XP_038960365.1

EC 3.1.3.16

EC 3.1.3.27

EC 3.1.3.48

XP_038960366.1

EC 3.1.3.16

EC 3.1.3.27

EC 3.1.3.48

XP_038960367.1

EC 3.1.3.16

EC 3.1.3.27

EC 3.1.3.48

XP_063139270.1

EC 3.1.3.16

EC 3.1.3.27

EC 3.1.3.48

XP_063139271.1

EC 3.1.3.16

EC 3.1.3.27

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105726.1 → NP_001099196.1 phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

See identical proteins and their annotated locations for NP_001099196.1

Status: PROVISIONAL

Source sequence(s)

CH473949

UniProtKB/TrEMBL

A6HN92, G3V7B6

Related

ENSRNOP00000013584.4, ENSRNOT00000013584.7

Conserved Domains (1) summary

cl21483
Location:139 → 240

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

97345752..97355396 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039104437.2 → XP_038960365.1 phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 isoform X3

Conserved Domains (1) summary

cl28904
Location:95 → 158

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_063283200.1 → XP_063139270.1 phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 isoform X1
XM_039104436.2 → XP_038960364.1 phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 isoform X2

Conserved Domains (1) summary

cl28904
Location:95 → 179

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_039104439.2 → XP_038960367.1 phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 isoform X6

Conserved Domains (1) summary

cl28904
Location:95 → 122

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_063283201.1 → XP_063139271.1 phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 isoform X4
XM_039104438.2 → XP_038960366.1 phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 isoform X5

Conserved Domains (1) summary

cl28904
Location:95 → 143

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily