Glra3 glycine receptor, alpha 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Glra3provided by RGD
Full Name: glycine receptor, alpha 3provided by RGD
Primary source: RGD:621229
See related: EnsemblRapid:ENSRNOG00000049792 AllianceGenome:RGD:621229
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables extracellularly glycine-gated chloride channel activity. Involved in several processes, including cellular response to ethanol; cellular response to zinc ion; and chloride transmembrane transport. Located in plasma membrane. Is active in glycinergic synapse and postsynaptic specialization membrane. Orthologous to human GLRA3 (glycine receptor alpha 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 22.2) and Adrenal (RPKM 5.7) See more
Orthologs: human mouse all
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Genomic context

Location:: 16p11

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (39210534..39857332, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (34199937..34848773, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (37676959..37908221, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Streptozotocin-Induced Diabetic Rats Showed a Differential Glycine Receptor Expression in the Spinal Cord: A GlyR Role in Diabetic Neuropathy.
Title: Streptozotocin-Induced Diabetic Rats Showed a Differential Glycine Receptor Expression in the Spinal Cord: A GlyR Role in Diabetic Neuropathy.
data show that the current-voltage relationships of homomeric channels formed by the alpha2 or alpha3 subunits change upon receptor desensitization from a linear to an inwardly rectifying shape, in contrast to their heteromeric counterparts.
Title: Electrophysiological Signature of Homomeric and Heteromeric Glycine Receptor Channels.
The kinetic properties of the alpha3 rat glycine receptor make it suitable for mediating fast synaptic inhibition.
Title: The kinetic properties of the α3 rat glycine receptor make it suitable for mediating fast synaptic inhibition.
Alteration in glycine receptor subunit expression starts as early as 6 hours after spinal cord injury.
Title: Differential expression of glycine receptor subunit messenger RNA in the rat following spinal cord injury.
Using chimeras of alpha1 and alpha3 subunit containing glycine receptors, we identified the structurally divergent M4 transmembrane segment and C-terminal tail as a specific determinant of the efficacy difference.
Title: The M4 transmembrane segment contributes to agonist efficacy differences between alpha1 and alpha3 glycine receptors.
the long (L) splice variant of GlyR alpha3 predominates in the brain of rodents. In primary hippocampal neurons GlyR alpha3L clusters also preferred glutamatergic nerve endings while alpha3K was mainly in a diffuse state.
Title: Splice-specific roles of glycine receptor alpha3 in the hippocampus.
GlyR alpha3(P185L), a result of cytidine 554 deamination, confers high glycine sensitivity (EC50 approximately 5 microM) to neurons and thereby promotes the generation of sustained chloride conductances associated with tonic inhibition
Title: RNA editing produces glycine receptor alpha3(P185L), resulting in high agonist potency.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
contributes_to chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables excitatory extracellular ligand-gated monoatomic ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables extracellularly glycine-gated chloride channel activity	IDA Inferred from Direct Assay more info	PubMed
enables extracellularly glycine-gated chloride channel activity	IEA Inferred from Electronic Annotation more info
enables extracellularly glycine-gated chloride channel activity	ISO Inferred from Sequence Orthology more info
enables glycine binding	IEA Inferred from Electronic Annotation more info
enables glycine-gated chloride ion channel activity	IEA Inferred from Electronic Annotation more info
enables glycine-gated chloride ion channel activity	ISO Inferred from Sequence Orthology more info
enables glycine-gated chloride ion channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to amino acid stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to ethanol	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to zinc ion	IDA Inferred from Direct Assay more info	PubMed
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in chloride transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in presynaptic modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
part_of glycine-gated chloride channel complex	IEA Inferred from Electronic Annotation more info
part_of glycine-gated chloride channel complex	ISO Inferred from Sequence Orthology more info
part_of glycine-gated chloride channel complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in glycinergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glycinergic synapse	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glycine receptor subunit alpha-3

Names: glycine receptor subunit alpha-3-like; glycine receptor, alpha 3 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053724.5 → NP_446176.4 glycine receptor subunit alpha-3 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/Swiss-Prot

P24524

Related

ENSRNOP00000105054.1, ENSRNOT00000167098.1