Trpc3 transient receptor potential cation channel, subfamily C, member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Trpc3provided by RGD
Official Full Name: transient receptor potential cation channel, subfamily C, member 3provided by RGD
Primary source: RGD:61973
See related: EnsemblRapid:ENSRNOG00000016070 AllianceGenome:RGD:61973
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Trrp3; TrpC3c
Summary: Enables calcium-activated cation channel activity. Predicted to be involved in several processes, including positive regulation of calcium ion transport into cytosol; positive regulation of cardiac muscle hypertrophy in response to stress; and response to ATP. Predicted to be located in membrane. Predicted to be part of cation channel complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in cerebellar ataxia type 41. Orthologous to human TRPC3 (transient receptor potential cation channel subfamily C member 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Uterus (RPKM 97.8), Brain (RPKM 72.2) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q25

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (121409436..121487095, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (119481313..119619333, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (123329954..123467574, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Soluble epoxide hydrolase and TRPC3 channels jointly contribute to homocysteine-induced cardiac hypertrophy: Interrelation and regulation by C/EBPbeta.
Title: Soluble epoxide hydrolase and TRPC3 channels jointly contribute to homocysteine-induced cardiac hypertrophy: Interrelation and regulation by C/EBPβ.
TRPC3-Nox2 Protein Complex Formation Increases the Risk of SARS-CoV-2 Spike Protein-Induced Cardiomyocyte Dysfunction through ACE2 Upregulation.
Title: TRPC3-Nox2 Protein Complex Formation Increases the Risk of SARS-CoV-2 Spike Protein-Induced Cardiomyocyte Dysfunction through ACE2 Upregulation.
Increased transient receptor potential canonical 3 activity is involved in the pathogenesis of detrusor overactivity by dynamic interaction with Na(+)/Ca(2+) exchanger 1.
Title: Increased transient receptor potential canonical 3 activity is involved in the pathogenesis of detrusor overactivity by dynamic interaction with Na(+)/Ca(2+) exchanger 1.
We demonstrate that TRPC3-NFATc3 signaling is modulated by P.E. and critically regulates ventricular CF phenotype and MF. These findings strongly argue for P.E., through TRPC3 targeting, as potential and interesting therapeutics for MF management.
Title: Transient Receptor Potential Canonical 3 and Nuclear Factor of Activated T Cells C3 Signaling Pathway Critically Regulates Myocardial Fibrosis.
Pharmacologically attenuating endogenous activation of TRPM4, TRPC3, or Ca(2+)-activated nonselective cation current in vitro similarly reduced the amplitude of inspiratory motoneuronal activity without significant perturbations of inspiratory frequency or variability of the rhythm. Amplitude perturbations were correlated with reduced inspiratory glutamatergic pre-Botzinger complex neuronal activity.
Title: Transient Receptor Potential Channels TRPM4 and TRPC3 Critically Contribute to Respiratory Motor Pattern Formation but not Rhythmogenesis in Rodent Brainstem Circuits.
Inhibition of TRPC3 suppressed intracellular Ca(2+) levels in hyperthermia-treated hippocampal neuronal cells
Title: Canonical Transient Receptor Potential Channel 3 Contributes to Febrile Seizure Inducing Neuronal Cell Death and Neuroinflammation.
In the trigeminal ganglion (TG), 56.1, 84.1, and 68.3% of sensory neurons were immunoreactive (IR) for TRPC1, TRPC3, and TRPC4, respectively.
Title: TRPC1, TRPC3, and TRPC4 in Rat Orofacial Structures.
Findings indicate that PI3K/AKT may be common down-stream molecules for TRPC3- and ETB receptor signaling pathways during vasogenic edema formation. In addition, the present data demonstrate for the first time that TRPC3 may integrate VEGF- and NFkappaB-mediated vasogenic edema formation following SE.
Title: TRPC3- and ET(B) receptor-mediated PI3K/AKT activation induces vasogenic edema formation following status epilepticus.
Transient receptor potential canonical 3 (TRPC3), a Ca(2+)-permeable channel, acts as a positive regulator of ROS in neonatal rat cardiomyocytes.
Title: TRPC3 positively regulates reactive oxygen species driving maladaptive cardiac remodeling.
Enhanced TRPC3 activity at the cytoplasmic and mitochondrial levels contributes to redox signaling and calcium dysregulation in the vasculature from spontaneously hypertensive rats.
Title: Enhanced Mitochondrial Transient Receptor Potential Channel, Canonical Type 3-Mediated Calcium Handling in the Vasculature From Hypertensive Rats.

Submit: New GeneRIF Correction See all GeneRIFs (56)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH129709 (e-PCR)
- UniSTS:213004

RH139923 (e-PCR)
- UniSTS:222007

RH144026 (e-PCR)
- UniSTS:233272

D2Got77 (e-PCR)
- UniSTS:112728

D2Rat340 (e-PCR), detects polymorphism
- UniSTS:227474

BE116826 (e-PCR)
- UniSTS:248547

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium channel activity	IEA Inferred from Electronic Annotation more info
enables calcium channel activity	ISO Inferred from Sequence Orthology more info
enables calcium-activated cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables inositol 1,4,5 trisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables inositol 1,4,5 trisphosphate binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables store-operated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables store-operated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables store-operated calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion transport into cytosol	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac muscle hypertrophy in response to stress	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to ATP	ISO Inferred from Sequence Orthology more info
involved_in response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in single fertilization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of cation channel complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: short transient receptor potential channel 3

Names: ion channel protein; trp-related protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001415005.1 → NP_001401934.1 short transient receptor potential channel 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

F1LNQ7, Q9JMI9

UniProtKB/TrEMBL

A0A0G2KAL8

Related

ENSRNOP00000046270.5, ENSRNOT00000046700.7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

121409436..121487095 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039103015.2 → XP_038958943.1 short transient receptor potential channel 3 isoform X3

UniProtKB/TrEMBL

A0A0G2KAL8

Related

ENSRNOP00000100915.1, ENSRNOT00000080207.4

Conserved Domains (2) summary

TIGR00870
Location:39 → 833

trp; transient-receptor-potential calcium channel protein

sd00045
Location:89 → 120

ANK; ANK repeat [structural motif]
XM_008760941.4 → XP_008759163.1 short transient receptor potential channel 3 isoform X2

UniProtKB/TrEMBL

A0A0G2KAL8

Related

ENSRNOP00000095733.2, ENSRNOT00000109104.3

Conserved Domains (2) summary

TIGR00870
Location:84 → 850

trp; transient-receptor-potential calcium channel protein

sd00045
Location:134 → 165

ANK; ANK repeat [structural motif]
XM_039103014.2 → XP_038958942.1 short transient receptor potential channel 3 isoform X1

UniProtKB/TrEMBL

A0A0G2KAL8

Conserved Domains (2) summary

TIGR00870
Location:84 → 877

trp; transient-receptor-potential calcium channel protein

sd00045
Location:134 → 165

ANK; ANK repeat [structural motif]
XM_063282439.1 → XP_063138509.1 short transient receptor potential channel 3 isoform X4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_021771.2: Suppressed sequence

Description

NM_021771.2: This RefSeq was suppressed because currently there is not sufficient data to support this transcript.