Lpar3 lysophosphatidic acid receptor 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Lpar3provided by RGD
Full Name: lysophosphatidic acid receptor 3provided by RGD
Primary source: RGD:620565
See related: EnsemblRapid:ENSRNOG00000064204 AllianceGenome:RGD:620565
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Edg7
Summary: Enables G-protein alpha-subunit binding activity and phospholipid binding activity. Involved in G protein-coupled receptor signaling pathway and positive regulation of calcium ion transport. Predicted to be located in axon. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human LPAR3 (lysophosphatidic acid receptor 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 59.9), Lung (RPKM 38.6) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q44

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (237785371..237854199)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (235125234..235193916)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (252090634..252159221)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pretreatment of primary hepatocytes with lysophosphatidic acid (LPA) resulted in an inhibition of insulin-mediated Gck expression, PI3K activation and glycogen synthesis. Pharmacological approaches revealed that the LPA3-receptor subtype is responsible for the inhibitory effect of LPA on insulin signaling.
Title: Lysophosphatidic Acid Inhibits Insulin Signaling in Primary Rat Hepatocytes via the LPA3 Receptor Subtype and is Increased in Obesity.
Data showed that lysophosphatidic acid receptors LPA1-3, are phosphoproteins whose phosphorylation state is modulated by the natural agonist, LPA.
Title: Phosphorylation and Internalization of Lysophosphatidic Acid Receptors LPA1, LPA2, and LPA3.
Lysophosphatidic acid signaling through LPA3 may be involved in cell motile activity stimulated by ethionine in WB-F344 cells.
Title: Ethionine regulates cell motile activity through LPA receptor-3 in liver epithelial WB-F344 cells.
Data suggest that signal transduction involving lysophosphatidic acid and Lpar3 is involved in uterine vascularization and decidualization, two main processes that prepare uterine milieu for embryo invasion during implantation.
Title: Lysophosphatidic acid increases the production of pivotal mediators of decidualization and vascularization in the rat uterus.
These findings identified opposite subtype-specific functions for LPA1 and LPA3 in mediating cardiomyocyte hypertrophy and indicated LPA1 to be a target of miR-23a
Title: Reciprocal regulation of miR-23a and lysophosphatidic acid receptor signaling in cardiomyocyte hypertrophy.
These results suggest that LPA3 may be involved in progression and aggressiveness of rat hepatoma RH7777 cells.
Title: Lysophosphatidic acid receptor-3 increases tumorigenicity and aggressiveness of rat hepatoma RH7777 cells.
The expression of LPA1 and LPA3 in rat aortic smooth muscle cells.
Title: The role of lysophosphatidic acid receptors in phenotypic modulation of vascular smooth muscle cells.
LPA (lysophosphatidic acid) receptors couple to Gq in VSMC (vascular smooth muscle cells)and mediate migration and proliferation which may be mediated through activation of ERK1/2 and Akt.
Title: Vascular smooth muscle migration and proliferation in response to lysophosphatidic acid (LPA) is mediated by LPA receptors coupling to Gq.
This study suggests that loss of the Lpar3 due to aberrant DNA methylation may be involved in the progression of rat lung tumor cells.
Title: Loss of lysophosphatidic acid receptor-3 enhances cell migration in rat lung tumor cells.

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General gene information

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Markers

PMC133668P2 (e-PCR)
- UniSTS:270635

RH131545 (e-PCR)
- UniSTS:214828

Edg7 (e-PCR), detects polymorphism
- UniSTS:259394

AU029210 (e-PCR)
- UniSTS:111594

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G-protein alpha-subunit binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables lysophosphatidic acid receptor activity	IEA Inferred from Electronic Annotation more info
enables phospholipid binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in bleb assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within bleb assembly	ISO Inferred from Sequence Orthology more info
involved_in collateral sprouting	IEA Inferred from Electronic Annotation more info
acts_upstream_of collateral sprouting	ISO Inferred from Sequence Orthology more info
involved_in gene expression	IEA Inferred from Electronic Annotation more info
involved_in gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of collateral sprouting	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of collateral sprouting	ISO Inferred from Sequence Orthology more info
involved_in regulation of metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
located_in axon	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: lysophosphatidic acid receptor 3

Names: LPA receptor 3; LPA-3; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 7; lysophosphatidic acid receptor Edg-7; putative G protein-coupled receptor snGPCR32; snGPCR32

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023969.2 → NP_076459.2 lysophosphatidic acid receptor 3

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A0A8I6A9K7

Conserved Domains (1) summary

cd15343
Location:22 → 295

7tmA_LPAR3_Edg7; lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial differentiation gene 7 (Edg7), member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

237785371..237854199

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006233470.5 → XP_006233532.1 lysophosphatidic acid receptor 3 isoform X1

See identical proteins and their annotated locations for XP_006233532.1

UniProtKB/Swiss-Prot

Q8K5E0, Q9ESJ6

UniProtKB/TrEMBL

A6HWD3

Conserved Domains (1) summary

cd15343
Location:31 → 304

7tmA_LPAR3_Edg7; lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial differentiation gene 7 (Edg7), member of the class A family of seven-transmembrane G protein-coupled receptors
XM_006233469.5 → XP_006233531.1 lysophosphatidic acid receptor 3 isoform X1

See identical proteins and their annotated locations for XP_006233531.1

UniProtKB/Swiss-Prot

Q8K5E0, Q9ESJ6

UniProtKB/TrEMBL

A6HWD3

Related

ENSRNOP00000089155.2, ENSRNOT00000112864.2

Conserved Domains (1) summary

cd15343
Location:31 → 304

7tmA_LPAR3_Edg7; lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial differentiation gene 7 (Edg7), member of the class A family of seven-transmembrane G protein-coupled receptors
XM_039103115.1 → XP_038959043.1 lysophosphatidic acid receptor 3 isoform X1

UniProtKB/Swiss-Prot

Q8K5E0, Q9ESJ6

UniProtKB/TrEMBL

A6HWD3

Conserved Domains (1) summary

cd15343
Location:31 → 304

7tmA_LPAR3_Edg7; lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial differentiation gene 7 (Edg7), member of the class A family of seven-transmembrane G protein-coupled receptors