Ces2c carboxylesterase 2C [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Ces2cprovided by RGD
Full Name: carboxylesterase 2Cprovided by RGD
Primary source: RGD:621510
See related: EnsemblRapid:ENSRNOG00000036571 AllianceGenome:RGD:621510
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ces2; Ces2l; ACH M1; CESRL4
Summary: Enables retinyl-palmitate esterase activity. Predicted to be involved in retinoid metabolic process. Located in intracellular membrane-bounded organelle. Orthologous to human CES2 (carboxylesterase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 99.1), Kidney (RPKM 85.3) and 3 other tissues See more
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Genomic context

Location:: 1q55

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (270377201..270384768)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (260391190..260398757)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (282640752..282648319)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

comparative analysis of CES1 and CES2 in liver and small intestine of humans, monkeys, dogs, rabbits and rats
Title: Carboxylesterase in the liver and small intestine of experimental animals and human.
CES2 isoenzymes shown to be major intestinal esterases in first pass hydrolysis of ester containing drugs.
Title: Intestinal first-pass metabolism via carboxylesterase in rat jejunum and ileum.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables acylcarnitine hydrolase activity	ISO Inferred from Sequence Orthology more info
enables all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity	IEA Inferred from Electronic Annotation more info
enables carboxylic ester hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables carboxylic ester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables retinyl-palmitate esterase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in retinoid metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in retinol metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: acylcarnitine hydrolase

Names: acylcarnitine hydrolase-like; carboxylesterase 2 (intestine, liver); carboxylic ester hydrolase

NP_598270.2

EC 3.1.1.28

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133586.3 → NP_598270.2 acylcarnitine hydrolase precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

G3V9D8, O70631

UniProtKB/TrEMBL

A0A0G2K455

Related

ENSRNOP00000064884.3, ENSRNOT00000074303.3

Conserved Domains (1) summary

pfam00135
Location:32 → 540

COesterase; Carboxylesterase family