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    Gucy1b2 guanylate cyclase 1 soluble subunit beta 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25206, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gucy1b2provided by RGD
    Official Full Name
    guanylate cyclase 1 soluble subunit beta 2provided by RGD
    Primary source
    RGD:2770
    See related
    EnsemblRapid:ENSRNOG00000009440 AllianceGenome:RGD:2770
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    SGC; Gucy1b2a; Gucy1b2b
    Summary
    Enables nitric oxide binding activity. Predicted to be involved in cGMP-mediated signaling and response to oxygen levels. Predicted to be located in cytosol. Predicted to be part of guanylate cyclase complex, soluble. Orthologous to human GUCY1B2 (guanylate cyclase 1 soluble subunit beta 2 (pseudogene)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 119.4), Liver (RPKM 107.1) and 1 other tissue See more
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    Genomic context

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    See Gucy1b2 in Genome Data Viewer
    Location:
    15p12
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (40774907..40845463, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (36589501..36669441, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (45479662..45550285, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene deleted in lymphocytic leukemia, 7 Neighboring gene ribonuclease H2, subunit B Neighboring gene uncharacterized LOC120097007 Neighboring gene similar to human chromosome 13 open reading frame 42 Neighboring gene uncharacterized LOC134482129 Neighboring gene family with sequence similarity 124 member A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The beta 2 subunit of nitric oxide-sensitive guanylyl cyclase is developmentally regulated in rat kidney. Behrends S, et al. Naunyn Schmiedebergs Arch Pharmacol, 2001 Dec. PMID 11770014
    2. Nitric oxide activates the beta 2 subunit of soluble guanylyl cyclase in the absence of a second subunit. Koglin M, et al. J Biol Chem, 2001 Aug 17. PMID 11406623
    3. [Changes in the consciousness state as a symptom of intestinal invagination onset]. Sangermani R, et al. Pediatr Med Chir, 1992 Nov-Dec. PMID 1298938
    4. Characterization of functional heme domains from soluble guanylate cyclase. Karow DS, et al. Biochemistry, 2005 Dec 13. PMID 16331987, Free PMC Article
    5. Soluble guanylate cyclase and neuronal nitric oxide synthase colocalize in rat nucleus tractus solitarii. Lin LH, et al. J Chem Neuroanat, 2005 Mar. PMID 15652699

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data support our hypothesis and provide anatomical support for the suggestion that nitroxidergic activation of the NTS involves sGC.
      Title: Soluble guanylate cyclase and neuronal nitric oxide synthase colocalize in rat nucleus tractus solitarii.
    2. Expression of the beta 2 subunit of soluble guanylyl cyclase is switched on at a time when the urinary concentrating capacity develops, between postnatal days 16 to 22, increasing strongly in intensity in adult animals.
      Title: The beta 2 subunit of nitric oxide-sensitive guanylyl cyclase is developmentally regulated in rat kidney.
    3. Results identify and characterize the minimum functional ligand-binding heme domain derived from soluble guanylate cyclase.
      Title: Characterization of functional heme domains from soluble guanylate cyclase.
    4. for the function of sGC in vivo, where there is evidence for two nitric oxide-regulated activity states
      Title: Dissociation of nitric oxide from soluble guanylate cyclase and heme-nitric oxide/oxygen binding domain constructs.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nitric oxide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cGMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cGMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to oxygen levels IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of guanylate cyclase complex, soluble IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    guanylate cyclase soluble subunit beta-2
    Names
    GCS-beta-2
    Guanylate cyclase, soluble, beta 2 (GTP pyrophosphate - lyase)
    guanylate cyclase 1, soluble, beta 2
    soluble guanylate cyclase beta 2a
    soluble guanylate cyclase beta 2b
    NP_001257640.1
    NP_036902.2
    XP_008768963.3
    XP_063130063.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270711.1 → NP_001257640.1  guanylate cyclase soluble subunit beta-2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AB109451, AY004153, M57507
      UniProtKB/TrEMBL
      A0A0G2QC51, Q91XJ7
      Related
      ENSRNOP00000012948.4, ENSRNOT00000012948.7
      Conserved Domains (4) summary
      smart00044
      Location:432 → 622
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:459 → 642
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam07700
      Location:2 → 163
      HNOB; Haem-NO-binding
      pfam07701
      Location:267 → 453
      HNOBA; Heme NO binding associated

    2. NM_012770.2 → NP_036902.2  guanylate cyclase soluble subunit beta-2 isoform 2

      See identical proteins and their annotated locations for NP_036902.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AB109451, M57507
      UniProtKB/TrEMBL
      F1M7R3, Q80WY0
      Conserved Domains (4) summary
      smart00044
      Location:397 → 587
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:424 → 607
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam07700
      Location:1 → 128
      HNOB; Haem-NO-binding
      pfam07701
      Location:232 → 418
      HNOBA; Heme NO binding associated

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      40774907..40845463 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008770741.4 → XP_008768963.3  guanylate cyclase soluble subunit beta-2 isoform X2

      UniProtKB/TrEMBL
      Q91XJ7
      Related
      ENSRNOP00000071659.1, ENSRNOT00000081912.3

    2. XM_063273993.1 → XP_063130063.1  guanylate cyclase soluble subunit beta-2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4T2, Q91XJ7
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P22717.1 GenPept UniProtKB/Swiss-Prot:P22717

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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