Grk5 G protein-coupled receptor kinase 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Grk5provided by RGD
Official Full Name: G protein-coupled receptor kinase 5provided by RGD
Primary source: RGD:61985
See related: EnsemblRapid:ENSRNOG00000011439 AllianceGenome:RGD:61985
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gprk5
Summary: Predicted to enable beta-adrenergic receptor kinase activity and protein serine/threonine kinase activity. Involved in negative regulation of G protein-coupled receptor signaling pathway; oligodendrocyte differentiation; and response to cocaine. Predicted to be located in cytosol; nucleus; and plasma membrane. Predicted to be active in cytoplasm. Biomarker of Parkinson's disease and hypertension. Orthologous to human GRK5 (G protein-coupled receptor kinase 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 258.1), Heart (RPKM 102.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q55

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (270014314..270208294)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (260028269..260223699)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (282265371..282467842)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRPA1 deficiency attenuates cardiac fibrosis via regulating GRK5/NFAT signaling in diabetic rats.
Title: TRPA1 deficiency attenuates cardiac fibrosis via regulating GRK5/NFAT signaling in diabetic rats.
Overexpression of GRK5-NT in cardiomyoblasts significantly reduced the activation and the nuclear translocation of NFAT and its cofactor GATA-4 in response to phenylephrine.
Title: The Amino-Terminal Domain of GRK5 Inhibits Cardiac Hypertrophy through the Regulation of Calcium-Calmodulin Dependent Transcription Factors.
This study showed that the GRK5 was involved in the development of epilepsy. It was associated with dendritic formation in epilepsy.
Title: The expression of G protein-coupled receptor kinase 5 and its interaction with dendritic marker microtubule-associated protein-2 after status epilepticus.
results suggest that GRK5 may be involved in a UII-mediated hypertrophic response via activation of NF-kappaB and HDAC5 at least in part by ERK1/2 and GSK3alpha/beta-independent pathways.
Title: A novel role of G protein-coupled receptor kinase 5 in urotensin II-stimulated cellular hypertrophy in H9c2(UT) cells.
Suggest a common regulatory pattern for the beta(1)-AR/GRK5 which is independent of cellular type or pathology.
Title: β2- and β1-Adrenoceptor Expression Exhibits a Common Regulatory Pattern With GRK2 and GRK5 in Human and Animal Models of Cardiovascular Diseases.
GRK5 nuclear translocation downstream of select Gq-activating hypertrophic ligands is a calmodulin-dependent process
Title: Nuclear translocation of cardiac G protein-Coupled Receptor kinase 5 downstream of select Gq-activating hypertrophic ligands is a calmodulin-dependent process.
sustained activation of CB2 receptors, which up-regulates 5-HT2A receptor signaling, enhances GRK5 expression; the phosphorylation of CB2 receptors; and the beta-arrestin 2/ERK interactions.
Title: G-protein receptor kinase 5 regulates the cannabinoid receptor 2-induced up-regulation of serotonin 2A receptors.
These data suggest cell type- and subcellular compartment-dependent differences in GRK/arrestin-mediated desensitization and signaling.
Title: Distinct cellular and subcellular distributions of G protein-coupled receptor kinase and arrestin isoforms in the striatum.
metoprolol is a biased ligand that selectively activates a G protein-independent and GRK5/beta-arrestin2-dependent pathway, and induces cardiac fibrosis.
Title: Induction of cardiac fibrosis by β-blocker in G protein-independent and G protein-coupled receptor kinase 5/β-arrestin2-dependent Signaling pathways.
Increased GRK5 may regulate AT1R expression in chronic heart failure, and exercise training mitigates AT1R and its pathway components.
Title: Parallel changes in neuronal AT1R and GRK5 expression following exercise training in heart failure.

Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

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Markers

RH139164 (e-PCR)
- UniSTS:221250

AU047024 (e-PCR)
- UniSTS:110916

UniSTS:496009 (e-PCR)
- UniSTS:496009

Grk5 (e-PCR), detects polymorphism
- UniSTS:496009

D1Rat459 (e-PCR)
- UniSTS:227241

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor kinase activity	IC Inferred by Curator more info	PubMed
enables G protein-coupled receptor kinase activity	IEA Inferred from Electronic Annotation more info
enables beta-adrenergic receptor kinase activity	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in desensitization of G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fat cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in oligodendrocyte differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to cocaine	IEP Inferred from Expression Pattern more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in tachykinin receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: G protein-coupled receptor kinase 5

Names: g protein-coupled receptor kinase GRK5

NP_110456.2

EC 2.7.11.16

XP_038944728.1

EC 2.7.11.16

XP_038944729.1

EC 2.7.11.16

XP_038944734.1

EC 2.7.11.16

XP_038944738.1

EC 2.7.11.16

XP_038944748.1

EC 2.7.11.16

XP_038944755.1

EC 2.7.11.16

XP_038944756.1

EC 2.7.11.16

XP_063128278.1

EC 2.7.11.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030829.2 → NP_110456.2 G protein-coupled receptor kinase 5

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q62833

UniProtKB/TrEMBL

A6JIB2, F7EZU6, Q66HL7

Related

ENSRNOP00000015687.4, ENSRNOT00000015687.8

Conserved Domains (2) summary

cd05632
Location:183 → 495

STKc_GRK5; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5

cl02565
Location:53 → 175

RGS; Regulator of G protein signaling (RGS) domain superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

270014314..270208294

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039088820.2 → XP_038944748.1 G protein-coupled receptor kinase 5 isoform X5

UniProtKB/Swiss-Prot

Q62833

Conserved Domains (2) summary

cd05605
Location:235 → 472

STKc_GRK4_like; Catalytic domain of G protein-coupled Receptor Kinase 4-like Serine/Threonine Kinases

cl02565
Location:74 → 225

RGS; Regulator of G protein signaling (RGS) domain superfamily
XM_039088800.2 → XP_038944728.1 G protein-coupled receptor kinase 5 isoform X1

UniProtKB/Swiss-Prot

Q62833

Conserved Domains (2) summary

cd05632
Location:233 → 545

STKc_GRK5; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5

cl02565
Location:74 → 225

RGS; Regulator of G protein signaling (RGS) domain superfamily
XM_039088827.2 → XP_038944755.1 G protein-coupled receptor kinase 5 isoform X6

UniProtKB/TrEMBL

A0A8I5ZX64

Conserved Domains (2) summary

cd05632
Location:180 → 492

STKc_GRK5; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5

cl02565
Location:21 → 172

RGS; Regulator of G protein signaling (RGS) domain superfamily
XM_039088810.2 → XP_038944738.1 G protein-coupled receptor kinase 5 isoform X4

UniProtKB/Swiss-Prot

Q62833

Conserved Domains (2) summary

cd05632
Location:204 → 516

STKc_GRK5; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5

cl02565
Location:74 → 196

RGS; Regulator of G protein signaling (RGS) domain superfamily
XM_039088806.2 → XP_038944734.1 G protein-coupled receptor kinase 5 isoform X3

UniProtKB/Swiss-Prot

Q62833

Related

ENSRNOP00000104808.1, ENSRNOT00000139040.1

Conserved Domains (2) summary

cd05632
Location:212 → 524

STKc_GRK5; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5

cl02565
Location:53 → 204

RGS; Regulator of G protein signaling (RGS) domain superfamily
XM_039088801.2 → XP_038944729.1 G protein-coupled receptor kinase 5 isoform X2

UniProtKB/Swiss-Prot

Q62833

Conserved Domains (2) summary

cd05632
Location:225 → 537

STKc_GRK5; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5

cl02565
Location:66 → 217

RGS; Regulator of G protein signaling (RGS) domain superfamily
XM_063272208.1 → XP_063128278.1 G protein-coupled receptor kinase 5 isoform X8
XM_039088828.2 → XP_038944756.1 G protein-coupled receptor kinase 5 isoform X7

Conserved Domains (1) summary

cl21453
Location:4 → 300

PKc_like; Protein Kinases, catalytic domain