Anxa7 annexin A7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Anxa7provided by RGD
Official Full Name: annexin A7provided by RGD
Primary source: RGD:621173
See related: EnsemblRapid:ENSRNOG00000007136 AllianceGenome:RGD:621173
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables calcium-dependent phospholipid binding activity. Involved in membrane fusion; response to calcium ion; and response to organic cyclic compound. Predicted to be located in several cellular components, including chromaffin granule membrane; endoplasmic reticulum membrane; and nuclear envelope. Predicted to be active in several cellular components, including nucleus; plasma membrane; and vesicle membrane. Orthologous to human ANXA7 (annexin A7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 133.9), Spleen (RPKM 133.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p16

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (3869180..3897827)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (3821798..3849659)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (4254470..4281296)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

our findings suggest that ANXA7 contributed to secondary brain injury at least partially through regulating glutamate toxicity after intracerebral hemorrhage
Title: Critical role for Annexin A7 in secondary brain injury mediated by its phosphorylation after experimental intracerebral hemorrhage in rats.
our studies support in vivo association between surfactant secretion and cell surface A7 occurring by insertion into plasma membrane and by fusion of A7 containing lamellar bodies.
Title: Annexin A7 trafficking to alveolar type II cell surface: possible roles for protein insertion into membranes and lamellar body secretion.
Annexin A7 may function in co-ordination with SNARE proteins and that protein kinase activation may be required for annexin A7 trafficking.
Title: Annexin A7 and SNAP23 interactions in alveolar type II cells and in vitro: a role for Ca(2+) and PKC.
ANXA7 may play a potential role in the pathogenetic mechanisms of the rat lithium-pilocarpine model of acquired epilepsy.
Title: Expression and localization of annexin A7 in the rat lithium-pilocarpine model of acquired epilepsy.
Results suggest that interactions between the NH2- and COOH-termini are required for membrane binding, and aggregation and fusion properties of annexin A7.
Title: Partial truncation of the NH2-terminus affects physical characteristics and membrane binding, aggregation, and fusion properties of annexin A7.
the 10-residue domain (Y(11)-A(20)) in the NH(2)-terminus modifies the phospholipid binding and aggregation properties of annexin A7
Title: A ten-residue domain (Y11-A20) in the NH2-terminus modulates membrane association of annexin A7.

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General gene information

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Markers

RH128488 (e-PCR)
- UniSTS:211796

RH129297 (e-PCR)
- UniSTS:212604

D15Got1 (e-PCR)
- UniSTS:115192

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase-dependent fusogenic activity	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipid binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylserine binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in autophagy	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of establishment of localization in cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hemostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of insulin secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular water homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_positive_effect ion channel modulating, G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_positive_effect ligand-gated ion channel signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in membrane fusion	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_positive_effect phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_positive_effect positive regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell shape	ISO Inferred from Sequence Orthology more info
involved_in response to calcium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in response to organic cyclic compound	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to salt stress	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromaffin granule membrane	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in vesicle	ISO Inferred from Sequence Orthology more info
is_active_in vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: annexin A7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.