CORO1B coronin 1B [Homo sapiens (human)] - Gene

Summary

Official Symbol: CORO1Bprovided by HGNC
Official Full Name: coronin 1Bprovided by HGNC
Primary source: HGNC:HGNC:2253
See related: Ensembl:ENSG00000172725 MIM:609849; AllianceGenome:HGNC:2253
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CORONIN-2
Summary: Members of the coronin family, such as CORO1B, are WD repeat-containing actin-binding proteins that regulate cell motility (Cai et al., 2005 [PubMed 16027158]).[supplied by OMIM, Mar 2008]
Expression: Ubiquitous expression in prostate (RPKM 38.7), spleen (RPKM 34.9) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q13.2

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (67435510..67443809, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (67429626..67437925, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (67202981..67211280, complement)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Smoothelin-like 2 Inhibits Coronin-1B to Stabilize the Apical Actin Cortex during Epithelial Morphogenesis.
Title: Smoothelin-like 2 Inhibits Coronin-1B to Stabilize the Apical Actin Cortex during Epithelial Morphogenesis.
Coronin 1B regulates the TNFalpha-induced apoptosis of HUVECs by mediating the interaction between TRADD and FADD.
Title: Coronin 1B regulates the TNFα-induced apoptosis of HUVECs by mediating the interaction between TRADD and FADD.
VEGF-activated p38alpha phosphorylates coronin 1B at Ser2 and activates the Arp2/3 complex by liberating it from coronin 1B.
Title: Coronin 1B serine 2 phosphorylation by p38α is critical for vascular endothelial growth factor-induced migration of human umbilical vein endothelial cells.
Coronin 1B constitutively binds to TGF beta receptor I in vascular smooth muscle cells.
Title: Binding of coronin 1B to TβRI negatively regulates the TGFβ1 signaling pathway.
The loss of junctional NMIIA, upon Coronin 1B knockdown, perturbed RhoA signaling.
Title: Coronin 1B supports RhoA signaling at cell-cell junctions through Myosin II.
When cells undergo apoptosis in an epithelial monolayer, coronin 1B is recruited to the junctional cortex at apoptotic/neighbor cell interface in an E-cadherin-dependent fashion to support actin architectural reorganization, contractility, and extrusion.
Title: Coronin 1B Reorganizes the Architecture of F-Actin Networks for Contractility at Steady-State and Apoptotic Adherens Junctions.
Coronin 1B regulates S1P-induced human lung endothelial cell chemotaxis.
Title: Coronin 1B regulates S1P-induced human lung endothelial cell chemotaxis: role of PLD2, protein kinase C and Rac1 signal transduction.
analysis of the mechanism for negatively regulating Rho-kinase (ROCK) signaling through Coronin1B protein in neuregulin 1 (NRG-1)-induced tumor cell motility
Title: Novel mechanism for negatively regulating Rho-kinase (ROCK) signaling through Coronin1B protein in neuregulin 1 (NRG-1)-induced tumor cell motility.
Coronin 1B regulates leading edge dynamics and controls cell motility and interactions with the actin-related protein (Arp)2/3 complex
Title: Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility.
Study concludes that Coronin 1B's coordination of filament formation by Arp2/3 complex and filament turnover by Cofilin is required for effective lamellipodial protrusion and cell migration.
Title: Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables Arp2/3 complex binding	IDA Inferred from Direct Assay more info	PubMed
enables Arp2/3 complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables actin filament binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables cadherin binding	HDA more info	PubMed
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in actin filament branching	IDA Inferred from Direct Assay more info	PubMed
involved_in actin filament bundle assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to platelet-derived growth factor stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endothelial cell chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in endothelial cell chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of Arp2/3 complex-mediated actin nucleation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of smooth muscle cell chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of lamellipodium morphogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to cell leading edge	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of Arp2/3 complex-mediated actin nucleation	IC Inferred by Curator more info	PubMed
involved_in ruffle organization	IDA Inferred from Direct Assay more info	PubMed
involved_in wound healing	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in actin filament	IDA Inferred from Direct Assay more info	PubMed
located_in cell leading edge	IDA Inferred from Direct Assay more info	PubMed
located_in cell periphery	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
located_in focal adhesion	HDA more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in stress fiber	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: coronin-1B

Names: coronin, actin binding protein, 1B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001018070.3 → NP_001018080.1 coronin-1B

Status: VALIDATED

Description

Transcript Variant: This variant (2) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AP003419, BC006449, DA061767

Consensus CDS

CCDS8164.1

UniProtKB/Swiss-Prot

B2RD45, Q9BR76

Related

ENSP00000377471.1, ENST00000393893.5

Conserved Domains (2) summary

sd00039
Location:38 → 80

7WD40; WD40 repeat [structural motif]

cl25676
Location:10 → 485

WD40_4; Type of WD40 repeat
NM_020441.3 → NP_065174.1 coronin-1B

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AP003419, BC006449

Consensus CDS

CCDS8164.1

UniProtKB/Swiss-Prot

B2RD45, Q9BR76

Related

ENSP00000340211.5, ENST00000341356.10

Conserved Domains (2) summary

sd00039
Location:38 → 80

7WD40; WD40 repeat [structural motif]

cl25676
Location:10 → 485

WD40_4; Type of WD40 repeat